Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. J Org Chem. 2012 Jan 6;77(1):772-4. doi: 10.1021/jo2021407. Epub 2011 Dec 13. Enantioselective total synthesis of (+)-scuteflorin A using organocatalytic asymmetric epoxidation. Bartlett CJ(1), Day DP, Chan Y, Allin SM, McKenzie MJ, Slawin AM, Page PC. Author information: (1)School of Chemistry, University of East Anglia , Norwich Research Park, Norwich, Norfolk NR4 7TJ, UK. We report the first enantioselective total synthesis of (+)-scuteflorin A in 14% overall yield, employing a chiral iminium salt to effect an organocatalytic asymmetric epoxidation of xanthyletin in >99% ee as the key step. DOI: 10.1021/jo2021407 PMID: 22136178 [Indexed for MEDLINE] 2. J Nat Prod. 2009 Jun;72(6):983-7. doi: 10.1021/np900068t. Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. Li J(1), Ding Y, Li XC, Ferreira D, Khan S, Smillie T, Khan IA. Author information: (1)Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA. Two new dihydropyranocoumarins, scuteflorins A (1) and B (2), together with the known compounds decursin (3), chrysin (4), oroxylin A (5), wogonin (6), 5,7-dihydroxy-8,2'-dimethoxyflavone, dihydrochrysin, dihydrooroxylin A, lupenol, scutellaric acid, pomolic acid, ursolic acid, beta-sitosterol, daucosterol, and palmitic acid, were isolated from the aerial parts of Scutellaria lateriflora, commonly used as a dietary supplement. The structures of 1 and 2 were established by means of 1D and 2D NMR spectra as well as HRMS data. The absolute configuration of coumarins 1 and 2 was determined by comparison of experimental and theoretical calculated CD spectra. The cytotoxicity and antioxidant effects of the methanol extract of this plant and some of the constituent flavonoids were evaluated in vitro. DOI: 10.1021/np900068t PMID: 19555121 [Indexed for MEDLINE]