Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. Phytochemistry. 2018 Oct;154:39-46. doi: 10.1016/j.phytochem.2018.06.012. Epub 2018 Jun 28. Anti-inflammatory and antiproliferative diterpenoids from Plectranthus scutellarioides. Cretton S(1), Saraux N(1), Monteillier A(1), Righi D(1), Marcourt L(1), Genta-Jouve G(2), Wolfender JL(1), Cuendet M(1), Christen P(3). Author information: (1)School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Rue Michel-Servet 1, 1211 Geneva 4, Switzerland. (2)C-TAC, UMR 8638 CNRS, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, Avenue de l'Observatoire 4, 75006 Paris, France. (3)School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Rue Michel-Servet 1, 1211 Geneva 4, Switzerland. Electronic address: philippe.christen@unige.ch. Chemical investigation of the dichloromethane extract of the aerial parts of Plectranthus scutellarioides led to the isolation and characterization of 10 diterpenoids with an abietane skeleton and one cembrane-type diterpenoid. Among them, six have not yet been described in the literature. Their structures were established by 1D and 2D NMR, UV and IR spectroscopy, and HRESIMS. The relative configuration was determined by Gauge-Independent Atomic Orbital NMR chemical shift calculations supported by the advanced statistical method DP4 plus and further confirmed by electronic circular dichroism. The isolated constituents were evaluated for their in vitro NF-κB inhibitory activity, as well as for their cytotoxic effects in human multiple myeloma cancer stem cells and RPMI 8226 tumor cell line. Coleon O, coleon G, lanugone K and 6-acetylfredericone B showed the highest inhibitory effect against NF-κB, displaying IC50 of 11.2, 11.0, 4.5 and 9.7 μM, respectively. Coleon O exhibited also a significant activity towards human multiple myeloma cancer stem cells and RPMI 8226 cells with IC50 of 9.2 and 8.4 μM, respectively. Copyright © 2018 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.phytochem.2018.06.012 PMID: 29960256 [Indexed for MEDLINE] 2. Bioorg Med Chem. 2004 Jan 2;12(1):217-23. doi: 10.1016/j.bmc.2003.10.006. Effect of abietane diterpenes from Plectranthus grandidentatus on T- and B-lymphocyte proliferation. Cerqueira F(1), Cordeiro-Da-Silva A, Gaspar-Marques C, Simões F, Pinto MM, Nascimento MS. Author information: (1)CEQOFFUP, Faculdade de Farmácia Universidade do Porto, Porto, Portugal. Five known abietane diterpenes of the royleanone and coleon type, namely, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4) and coleon U (5), isolated from Plectranthus grandidentatus, were evaluated for their effect on the proliferation of human lymphocytes induced by the mitogen PHA. All except 4, showed a dose-dependent suppressor effect, with 3 yielding the most potent antiproliferative activity, followed by 5. These two compounds, that represent diterpenes of the royleanone and coleon type respectively, were also shown to be potent inhibitors of mouse splenocyte proliferation induced by ConA or LPS mitogens. However, the sensitivity of ConA-stimulated splenocytes to their suppressive effect was higher, suggesting a preferential inhibition of T-lymphocyte proliferation. The antiproliferative activity of 3 seemed to be exerted without affecting the expression of the lymphocyte activation marker CD69. On the contrary, 5 was shown to reduce the expression of CD69 of TCD8(+) and B-cells, suggesting a relationship between its antiproliferative effect and the expression of this early marker of activation on these cell populations. The capacity of 5 to induce apoptosis on ConA-stimulated splenocytes could also be related with its antiproliferative activity. DOI: 10.1016/j.bmc.2003.10.006 PMID: 14697786 [Indexed for MEDLINE] 3. Am J Contact Dermat. 1997 Mar;8(1):8-9. Airborne contact dermatitis from Coleus plant. Bryld LE(1). Author information: (1)Department of Dermatology, University of Copenhagen, Gentofte Hospital, Denmark. A 65-year-old woman with a 25-year history of facial dermatitis and no obvious external cause was patch tested with her houseplants and a wide range of common allergens. The only positive reaction found was to the plant Coleus blumei. PMID: 9066840 [Indexed for MEDLINE] 4. Contact Dermatitis. 1988 Sep;19(3):217-8. doi: 10.1111/j.1600-0536.1988.tb02902.x. Sensitizing potency of coleon O in Coleus sp. (Lamiaceae). Hausen BM(1), Devriese EG, Geuns JM. Author information: (1)Department of Dermatology, University Hospital, Hamburg, FRG. DOI: 10.1111/j.1600-0536.1988.tb02902.x PMID: 3191685 [Indexed for MEDLINE]