Psychoactive Plant Database - Neuroactive Phytochemical Collection

1. J Interpers Violence. 2024 Nov 7:8862605241297314. doi: 
10.1177/08862605241297314. Online ahead of print.

I Belong: Gender and Sexuality Minoritized Students' Positive Perceptions of 
Campus Climate Protect Against PTSD Following Sexual Assault.

Bilal NJ(1), Herres J(1).

Author information:
(1)The College of New Jersey, Ewing, USA.

Sexual assault is a widespread problem among institutions of higher education. 
Students whose gender and/or sexuality are minoritized (GSM; non-cisgender 
and/or non-heterosexual) are especially vulnerable to experiencing sexual 
assault and its negative consequences, including post-traumatic stress disorder 
(PTSD). A sense of belonging within the campus community can protect victims of 
sexual assault from negative psychological outcomes; however, no study to date 
has examined whether this aspect of a positive campus climate protects GSM 
victims, in particular, from developing more severe PTSD symptoms after sexual 
assault. We hypothesized that GSM victims would experience more severe PTSD 
symptoms than non-GSM victims after experiencing sexual assault and that their 
perceptions of campus climate would moderate this relationship. All 
undergraduate students from a public liberal arts college on the East Coast were 
asked to participate in an online survey about their history of sexual assault 
and emotional well-being. Of those who completed the survey, approximately 18% 
reported a history of sexual assault (N = 146). GSM victims of sexual assault 
reported more severe PTSD symptoms than non-GSM victims; however, a significant 
interaction showed that PTSD symptoms were similar for GSM and non-GSM victims 
with high ratings of campus climate. Thus, positive perceptions of campus 
climate protected GSM students from experiencing more severe PTSD symptoms. 
These findings inform administrative efforts by suggesting the need for more 
inclusive support resources (i.e., crisis centers and orientation materials), 
curricula, and community spaces for GSM students.

DOI: 10.1177/08862605241297314
PMID: 39508250

Conflict of interest statement: Declaration of Conflicting InterestsThe 
author(s) declared no potential conflicts of interest with respect to the 
research, authorship, and/or publication of this article.


2. Res Involv Engagem. 2024 Nov 6;10(1):115. doi: 10.1186/s40900-024-00651-6.

Engagement of people with lived experience in studies published in high-impact 
psychiatry journals: meta-research review.

Adams C(1)(2), Nassar EL(1)(3), Nordlund J(1), Hu S(1), Rice DB(4)(5), Cook 
V(1), Boruff J(6), Thombs BD(7)(8)(9)(10)(11)(12).

Author information:
(1)Lady Davis Institute for Medical Research, Jewish General Hospital, 3775 Cote 
Ste Catherine Road, Pavilion H4.83, Montreal, QC, H3T 1E2, Canada.
(2)Department of Psychiatry, McGill University, Montreal, QC, Canada.
(3)Department of Psychology, McGill University, Montreal, QC, Canada.
(4)Department of Psychology, St. Joseph's Healthcare Hamilton, Hamilton, ON, 
Canada.
(5)Department of Psychiatry & Behavioural Neurosciences, McMaster University, 
Hamilton, ON, Canada.
(6)Schulich Library of Physical Sciences, Life Sciences, and Engineering, McGill 
University, Montreal, QC, Canada.
(7)Lady Davis Institute for Medical Research, Jewish General Hospital, 3775 Cote 
Ste Catherine Road, Pavilion H4.83, Montreal, QC, H3T 1E2, Canada. 
brett.thombs@mcgill.ca.
(8)Department of Psychiatry, McGill University, Montreal, QC, Canada. 
brett.thombs@mcgill.ca.
(9)Department of Psychology, McGill University, Montreal, QC, Canada. 
brett.thombs@mcgill.ca.
(10)Department of Epidemiology, Biostatistics, and Occupational Health, McGill 
University, Montreal, QC, Canada. brett.thombs@mcgill.ca.
(11)Department of Medicine, McGill University, Montreal, QC, Canada. 
brett.thombs@mcgill.ca.
(12)Biomedical Ethics Unit, McGill University, Montreal, QC, Canada. 
brett.thombs@mcgill.ca.

BACKGROUND: We evaluated studies published in high-impact psychiatry journals to 
assess (1) the proportion that reported in articles whether they engaged people 
with lived experience; (2) the proportion that likely engaged people with lived 
experience; and, if engagement occurred, (3) stages of research (planning, 
conduct, interpretation, dissemination); and (4) engagement level (consult, 
involve, partner).
METHODS: We searched PubMed on December 14, 2022, for articles in psychiatry 
journals with impact factor ≥ 10 and reviewed articles in reverse chronological 
order until 141 were included, based on pre-study precision estimation. We 
contacted authors to obtain information on engagement.
RESULTS: Three of 141 (2%) studies reported engagement of people with lived 
experience in articles. Of the other 138 studies, 74 authors responded to 
follow-up emails and 22 reported they engaged people with lived experience but 
did not report in the article. Depending on assumptions about engagement by 
non-responders, we estimated, overall, 18-31% of studies may have engaged people 
with lived experience. Engagement occurred in research planning (70%) and rarely 
interpretation (35%). Most involved consultation (providing opinions or 
perspectives, 53%) and few involved partnership (11%).
CONCLUSIONS: Engagement of people with lived experience in psychiatry research 
is uncommon, and when it does occur people are typically consulted but not 
engaged in roles with influence on decision-making. Funding agencies, ethics 
committees, journals, and academic institutions should take steps to support 
engagement of people with lived experience in psychiatry research.

Plain Language Summary: Engaging people with lived experience in research is 
important to ensure research is relevant to people’s needs. We do not know, 
however, how often people with lived experience are engaged in psychiatry 
research and whether engagement is reported in journal articles. We evaluated 
studies published in top psychiatry journals and assessed the (1) percentage 
that reported in the articles whether they engaged people with lived experience 
and (2) percentage that likely engaged people with lived experience based on 
author queries. Additionally, if people with lived experience were engaged in 
the studies, we also evaluated (3) the stages of research that people with lived 
experience were involved in (planning, conduct, interpretation, dissemination); 
and (4) their level of influence on decision-making (consult, involve, partner). 
Articles published in psychiatry journals with impact factor greater than or 
equal to 10 were eligible. We searched for studies on PubMed, a popular database 
of medical research, and reviewed articles from most to least recent until 141 
were included. We calculated that we needed to review 141 articles to have 
enough to make reasonably precise estimates (confidence intervals around 
estimates of 10% or less) of how many studies engaged people with lived 
experience. We found that 3 of 141 (2%) studies reported on engagement in 
articles. We contacted authors of studies that did not report on engagement in 
their articles and asked whether they engaged people with lived experience. Of 
the 138 articles that did not report on engagement, 74 authors responded to 
email queries, and 22 reported they engaged people with lived experience. We 
estimated, overall, 18-31% of studies may have engaged people with lived 
experience, depending on whether we assumed that non-responders did or did not 
engage. Among all studies that engaged people with lived experience, both those 
reported and unreported in the articles, engagement commonly occurred in 
research planning (N = 14 of 20 studies, 70%) but rarely in the interpretation 
of results (N = 7 of 20 studies, 35%). Engagement mostly involved consultation, 
where people with lived experience provided perspectives to researchers (N = 10 
of 19 studies, 53%). Few involved partnership, where they worked with 
researchers to make decisions (N = 2 of 19 studies, 11%). Funding agencies, 
ethics committees, academic journals, and universities should take steps to 
support engagement of people with lived experience in psychiatry research.

© 2024. The Author(s).

DOI: 10.1186/s40900-024-00651-6
PMID: 39508249


3. BMC Vet Res. 2024 Nov 6;20(1):504. doi: 10.1186/s12917-024-04358-4.

Autologous platelet-rich fibrin enhances skin wound healing in a feline trauma 
model.

Zhang S(1), Tan H(1), Cheng X(1), Dou X(1), Fang H(2), Zhang C(3), Yang G(4), 
Yang H(1)(5), Zhao Y(1), Feng T(1), Fan H(6), Sha W(7)(8).

Author information:
(1)College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
China.
(2)College of Optoelectronic Engineering, Chongqing University, Chongqing, 
China.
(3)Hui Zhou Third People's Hospital, Guangzhou Medical University, Guangzhou, 
China.
(4)College of Veterinary Medicine, China Agricultural University, Beijing, 
China.
(5)Branch of Animal Husbandry and Veterinary of Heilongjiang Academy of 
Agricultural Sciences, Qiqihar, China.
(6)College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
China. fanhonggang2002@163.com.
(7)College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
China. jlshawanli@163.com.
(8)College of Animal Science and Technology, Jilin Agricultural Science and 
Technology University, Jilin, 132109, China. jlshawanli@163.com.

Trauma is a common cause of cutaneous surgical disease with an increased risk of 
secondary infection in cat clinics. Platelet-rich fibrin (PRF), a platelet and 
leukocyte concentrate containing multiple cytokines and growth factors, is known 
to accelerate the healing of wounds. However, how PRF affects wound healing in 
the cat trauma model has not been fully investigated. The study aimed to examine 
the impact of PRF on skin wound healing in the cat trauma model. In this study, 
PRF from cats was successfully produced for our investigation. The models of 
feline trauma were effectively established. A total of 18 cats were randomly 
divided into 3 groups (n = 6): (1) Control group (CON); (2) PRF group; (3) 
Manuka honey group (MAN, as a positive control). Experiments were performed 
separately on days 7, 14, 21, and 28. Our results showed that PRF was a safe and 
efficient method of wound healing that did not influence the cat's body 
temperature, respiration rate, and heart rate (HR). PRF accelerated skin wound 
healing in the cat trauma model based on the rate and histological observation 
of wound healing. In addition, PRF promoted the production of growth factors and 
suppressed inflammation during wound healing. PRF accelerated wound healing by 
increasing the formation of collagen fibers, as shown by Masson-trichrome 
staining. The outcomes of the PRF and MAN groups were comparable. In conclusion, 
PRF improves the healing of skin wounds in cats by boosting the synthesis of 
growth factors, reducing inflammation, and enhancing the synthesis of collagen 
fibers.

© 2024. The Author(s).

DOI: 10.1186/s12917-024-04358-4
PMID: 39508248


4. Chem Asian J. 2024 Nov 7:e202400916. doi: 10.1002/asia.202400916. Online ahead
 of print.

Chalcogen Bond-Driven Alkylations: Selenoxide-Pillar[5]arene As A Recyclable 
Catalyst For Displacement Reactions In Water.

Cordeiro P(1), Menezes V(1), Ángel AYB(2), de Andrade KN(1), Fiorot RG(1), 
Alberto EE(2), Nascimento V(3).

Author information:
(1)Federal Fluminense University, Organic Chemistry, BRAZIL.
(2)Federal University of Minas Gerais, Chemistry, BRAZIL.
(3)Universidade Federal Fluminense, Química Orgânica, OUTEIRO DE SÃO JOÃO 
BATISTA, S/N - CAMPUS DO VALONGUINHO, 24020141, NITERÓI, BRAZIL.

A novel strategy to catalyze alkylation reactions through chalcogen bond 
interaction using a supramolecular structure is presented herein. Utilizing just 
1.0 mol% of selenoxide-pillar[5]arene (P[5]SeO) as the catalyst we achieved 
efficient catalysis in the cyanation of benzyl bromide in water. Our approach 
demonstrated high efficiency and effectiveness, with the results supported by 
designed control experiments and theoretical models, highlighting the catalytic 
effect of the pillar[5]arene through noncovalent interactions. Quantum-chemical 
calculations (ωB97X-D/def2-TZVP@SMD) pointed out that the catalyzed cyanation 
reaction followed an SN2-like mechanism, with energy barriers (ΔH‡) ranging from 
16.7 to 18.2 kcal mol-1, exhibiting dissociative character depending on the 
para-substituent. 1H NMR analysis revealed that P[5]SeO acted as a catalyst 
through inclusion complex formation, facilitating the transfer of the 
electrophilic substrate to the aqueous solution for nucleophilic displacement. 
Our reaction protocol proved applicable to various substrates, including 
aromatic and alpha-carbonyl derivatives. The use of sodium azide as the 
nucleophile was also feasible. Importantly, our method allowed scalability, and 
the catalyst P[5]SeO could be recovered and reused effectively for multiple 
reaction cycles, showcasing sustainability.

© 2024 Wiley‐VCH GmbH.

DOI: 10.1002/asia.202400916
PMID: 39508242


5. S Afr Med J. 2024 Oct 3;114(10):e2237.

A quantitative assessment of the time to complete the Master of Medicine 
research thesis in a cohort of paediatrics registrars at the University of the 
Witwatersrand, South Africa.

Parry J(1), Coovadia A(2).

Author information:
(1)Department of Paediatrics and Child Health, Faculty of Health Sciences, 
University of the Witwatersrand, Johannesburg, South Africa.
(2)Head of Department of Paediatrics and Child Health, Rahima Moosa Mother and 
Child Hospital and Faculty of Health Sciences, University of the Witwatersrand, 
Johannesburg, South Africa.

BACKGROUND: The Health Professions Council of South Africa implemented a 
compulsory research component for specialist practitioner registration through 
the Master of Medicine (MMed) degree in 2011, eliciting both commendation and 
critique. Chief among the concerns is the extended time required for MMed 
completion. This study explores the duration of each component of the MMed 
research thesis and discusses the potential problematic areas in terms of its 
timeous completion, about which there is currently a lack of data, with 
particular regard to the South African (SA) setting.
OBJECTIVES: To quantitatively delineate the various components of the MMed 
research thesis process, identify potential barriers to its completion, and 
formulate a recommended evidence-based proposed timeline allowing for successful 
and timeous completion of the MMed.
METHODS: We conducted a retrospective review of MMed degrees completed by 
paediatrics registrars at the University of the Witwatersrand, Johannesburg, SA, 
from 1 January 2011 to 31 December 2018, and an electronic survey of former MMed 
students, detailing the duration of each of the components of the MMed research 
thesis process.
RESULTS: The survey had a 70.5% response rate (n=148 respondents, of whom 141 
fully completed the survey). The median (interquartile range) time to complete 
the MMed research thesis was 30 (21 - 42) months. While 78.0% of respondents 
deemed 4 years adequate for completion, 15.6% reported durations exceeding 4 
years, and 2.1% had not completed the MMed. The components of the research 
thesis with the longest duration in terms of completion included development of 
a first draft of the research protocol, data analysis, and development of the 
first draft of the final report. Factors reportedly associated with successful 
completion of the thesis were a supportive supervisor and the provision of a 
research rotation.
CONCLUSION: A significant portion of candidates do not complete the MMed 
research thesis within the 4-year training period, hindering specialist 
registration. The major contributing factors appear to be related to candidates' 
inexperience regarding the research process and lack of exposure to it, as well 
as some of the administrative procedures involved. Utilisation of the 
recommendations and structured timeline will help identify problematic areas 
timeously and ensure successful completion of the thesis.

PMID: 39508225 [Indexed for MEDLINE]