Psychoactive Plant Database - Neuroactive Phytochemical Collection

1. Research (Wash D C). 2024 Nov 6;7:0516. doi: 10.34133/research.0516.
eCollection  2024.

Holographic Ultrasound Modulates Neural Activity in a 
1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Mouse Model of Parkinson's 
Disease.

Zhou H(1)(2), Li F(1), Lin Z(1), Meng L(1), Chen D(3), Zhang Q(4), Niu L(1).

Author information:
(1)Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of 
Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, 
Chinese Academy of Sciences, Shenzhen, China.
(2)Tech X Academy, Shenzhen Polytechnic University, Shenzhen, China.
(3)Institute of Ultrasonic Technology, Institute of Intelligent Manufacturing 
Technology, Shenzhen Polytechnic University, Shenzhen, China.
(4)School of Electronic and Communication Engineering, Shenzhen Polytechnic 
University, Shenzhen, China.

Ultrasound (US) has emerged as a noninvasive neurostimulation method for motor 
control in Parkinson's disease (PD). Previous in vivo US neuromodulation studies 
for PD were single-target stimulation. However, the motor symptoms of PD are 
linked with neural circuit dysfunction, and multi-target stimulation is 
conducted in clinical treatment for PD. Thus, in the present study, we achieved 
multi-target US stimulation using holographic lens transducer based on the 
Rayleigh-Sommerfeld diffraction integral and time-reversal methods. We 
demonstrated that holographic US stimulation of the bilateral dorsal striatum 
(DS) could improve the motor function in 
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. 
The holographic US wave (fundamental frequency: 3 MHz, pulse repetition 
frequency: 500 Hz, duty cycle: 20%, tone-burst duration: 0.4 ms, sonication 
duration: 1 s, interstimulus interval: 4 s, spatial-peak temporal-average 
intensity: 180 mw/cm2) was delivered to the bilateral DS 20 min per day for 
consecutive 10 d after the last injection of MPTP. Immunohistochemical c-Fos 
staining demonstrated that holographic US significantly increased the 
c-Fos-positive neurons in the bilateral DS compared with the sham group (P = 
0.003). Moreover, our results suggested that holographic US stimulation of the 
bilateral DS ameliorated motor dysfunction (P < 0.05) and protected the 
dopaminergic (DA) neurons (P < 0.001). The neuroprotective effect of holographic 
US was associated with the prevention of axon degeneration and the reinforcement 
of postsynaptic densities [growth associated protein-43 (P < 0.001), 
phosphorylated Akt (P = 0.001), β3-tubulin (P < 0.001), phosphorylated CRMP2 (P 
= 0.037), postsynaptic density (P = 0.023)]. These data suggested that 
holographic US-induced acoustic radiation force has the potential to achieve 
multi-target neuromodulation and could serve as a reliable tool for the 
treatment of PD.

Copyright © 2024 Hui Zhou et al.

DOI: 10.34133/research.0516
PMCID: PMC11538569
PMID: 39507404

Conflict of interest statement: Competing interests: The authors declare that 
they have no competing interests.


2. BMC Public Health. 2024 Nov 6;24(1):3060. doi: 10.1186/s12889-024-20488-8.

Supporting vulnerable families' meal practices: process evaluation of a 
nationwide intervention implemented by a retailer and social organizations.

Marjolijn V(1)(2), Anneleen VK(3), Benedicte D(4)(5), Viktor P(3), Nathalie 
M(6), Maartje P(7), Maggie G(3), Wendy VL(3)(4).

Author information:
(1)Department of Marketing, Innovation and Organization, Faculty of Economics 
and Business Administration, Ghent University, Ghent, Belgium. 
Marjolijn.Vos@ugent.be.
(2)Unit Health Promotion, Faculty of Medicine and Health Sciences, Department of 
Public Health and Primary care, Ghent University, Ghent, Belgium. 
Marjolijn.Vos@ugent.be.
(3)Department of Marketing, Innovation and Organization, Faculty of Economics 
and Business Administration, Ghent University, Ghent, Belgium.
(4)Unit Health Promotion, Faculty of Medicine and Health Sciences, Department of 
Public Health and Primary care, Ghent University, Ghent, Belgium.
(5)Movement and Nutrition for Health and Performance Research Group, Faculty of 
Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, 
Belgium.
(6)Department of Public Health and Primary care, Faculty of Medicine and Health 
Sciences, Unit Public Health Nutrition, Ghent University, Ghent, Belgium.
(7)Chair Group Consumption and Healthy Lifestyles, Wageningen University & 
Research, Wageningen, The Netherlands.

BACKGROUND: Lower socioeconomic status (SES) is associated with poorer dietary 
habits and fewer family meals. Therefore, initiatives to empower families with a 
lower SES to adopt healthier meal practices are employed. The objective of this 
study was to evaluate a nationwide intervention "Dinner is served at 1-2-3 
euros", developed by a Belgian retailer in collaboration with social 
organizations. It targets families with a lower SES and aims to promote more 
balanced and freshly cooked meals by providing recipe booklets of affordable 
meals at a guaranteed price of 1, 2, or 3 euros per portion. The process 
evaluation aimed to gain insight into the implementation process (Reach, 
Recruitment, Dose-delivered, Context), the satisfaction with the intervention 
(Dose-received), and the perceived impact of intervention participation.
METHODS: A mixed-methods study combining qualitative (i.e., focus groups and 
individual interviews) and quantitative research (i.e., surveys) was conducted. 
An interview with the retailer (n = 1), three focus group interviews with the 
involved social organizations (n = 15), and interviews with participants of 
"Dinner is served at 1-2-3 euros" (n = 26) were carried out, as well as surveys 
among these social organizations and participants.
RESULTS: Social organizations were generally satisfied with the project and 
appreciated the collaboration with the retailer. The main barrier to implement 
the project was a lack of time to help participants subscribing. Participants 
appreciated the inspiration from the recipe booklets, and the recipes' ease of 
preparation, their healthiness, and the variety. However, the recipes were 
sometimes deemed too exotic for participants' children. Participants also 
appreciated the budget friendliness, although the price guarantee mechanism of 
1, 2 or 3 euros per portion was not always clear. Positive effects were 
mentioned in areas such as perceived healthy cooking and eating, improved 
cooking skills and ideas, and reduced financial concerns.
CONCLUSIONS: In general, participants and social organizations were satisfied 
with the delivery and implementation of the intervention. Participants also 
noted some positive effects on their meal practices. Future research should 
provide insight into the intervention's effectiveness and impact on the 
healthiness of participants' dietary choices.
TRIAL REGISTRATION: The study protocol was pre‑registered prior to data 
collection at Clinicaltrials.gov (NCT05595551-27/10/2022).

© 2024. The Author(s).

DOI: 10.1186/s12889-024-20488-8
PMID: 39506698 [Indexed for MEDLINE]


3. BMC Microbiol. 2024 Nov 6;24(1):453. doi: 10.1186/s12866-024-03587-9.

Gamma-irradiated copper-based metal organic framework nanocomposites for 
photocatalytic degradation of water pollutants and disinfection of some 
pathogenic bacteria and fungi.

El-Sayyad GS(1), El-Khawaga AM(2), Rashdan HRM(3).

Author information:
(1)Drug Microbiology Lab, Drug Radiation Research Department, National Center 
for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority 
(EAEA), Cairo, Egypt. Gharieb.S.Elsayyad@eaea.org.eg.
(2)Department of Basic Medical Sciences, Faculty of Medicine, Galala University, 
Galala City 43511, Suez, Egypt.
(3)Chemistry of Natural and Microbial Products Department, Pharmaceutical and 
Drug Industries Research Institute, National Research Centre, 33 El Buhouth St, 
Dokki, 12622, Giza, Egypt. hr.rashdan@nrc.sci.eg.

BACKGROUND: Although there are many uses for metal-organic framework (MOF) based 
nanocomposites, research shows that these materials have received a lot of 
interest in the field of water treatment, namely in the photodegradation of 
water contaminants, and disinfection of some pathogenic bacteria and fungi. This 
is brought on by excessive water pollution, a lack of available water, 
low-quality drinking water, and the emergence of persistent micro-pollutants in 
water bodies. Photocatalytic methods may be used to remove most water 
contaminants, and pathogenic microbes, and MOF is an excellent modifying and 
supporting material for photocatalytic degradation.
METHODS: This work involved the fabrication of a unique Cu-MOF based 
nanocomposite that was exposed to gamma radiation. The nanocomposite was 
subsequently employed for photocatalytic degradation and as an antimicrobial 
agent against certain harmful bacteria and fungi. The produced Cu-MOf 
nanocomposite was identified by XRD, SEM, and EDX. Growth curve analysis, UV 
lighting impact, and antibiofilm potential have been carried out to check 
antimicrobial potential. Additionally, the membrane leakage test was used to 
determine the mechanism of the antimicrobial action. In an experimental 
investigation of photocatalytic activity, a 50 mL aqueous solution including 
10.0 ppm of Rhodamine B (RB) was used to solubilize 10 mg of Cu-MOF. It has been 
investigated how pH and starting concentration affect RB elimination by Cu-MOF. 
Ultimately, RB elimination mechanism and kinetic investigations have been 
carried out.
RESULTS: SEM images from the characterization techniques demonstrated the fact 
that the Cu-MOF was synthesized effectively and exhibited the Cu-MOF layers' 
flake-like form. Uneven clusters of rods make up each stratum. The primary peaks 
in the Cu-MOF's diffraction pattern were found at 2θ values of 8.75◦, 14.83◦, 
17.75◦, 21.04◦, 22.17◦, 23.31◦, 25.41◦, and 26.38◦, according to the XRD data. 
After 135 min of UV irradiation, only 8% of RB had undergone photolytic 
destruction. On the other hand, the elimination resulting from adsorption during 
a 30-min period without light was around 16%. Conversely, after 135 min, 
Cu-MOF's photocatalytic breakdown of RB with UV light reached 81.3%. At pH 9.0, 
the greatest removal of RB at equilibrium was found, and when the amount of 
photocatalyst rose from 5 to 20 mg, the removal efficiency improved as well. The 
most sensitive organism to the synthesized Cu-MOF, according to antimicrobial 
data, was Candida albicans, with a documented MIC value of 62.5 µg mL-1 and 
antibacterial ZOI as 32.5 mm after 1000 ppm treatment. Cu-MOF also showed the 
same MIC (62.5 µg mL-1) values against Staphylococcus aureus and Escherichia 
coli, and 35.0 and 32.0 mm ZOI after 1000 ppm treatment, respectively. 
Ultimately, it was found that Cu-MOF (1000 µg/mL) after having undergone gamma 
irradiation (100.0 kGy) was more effective against S. aureus (42.5 mm ZOI) and 
E. coli (38.0 mm ZOI).
CONCLUSION: From the obtained results, the synthesized MOF nanocomposites had 
promising catalytic degradation of RB dye and high antimicrobial potential which 
encouraging their use in wastewater treatment against some pathogenic microbes 
and polluted dyes. Due to the exceptional physicochemical characteristics of 
MOF nanocomposites, it is possible to create and modify photocatalytic 
nanocomposites in a way that improves their recovery, efficiency, and 
recyclability.

© 2024. The Author(s).

DOI: 10.1186/s12866-024-03587-9
PMID: 39506685 [Indexed for MEDLINE]


4. J Pediatr Adolesc Gynecol. 2024 Nov 4:S1083-3188(24)00338-3. doi: 
10.1016/j.jpag.2024.10.006. Online ahead of print.

Natural History of Menstrual Pain and Associated Risk Factors in Early 
Adolescence.

Modarelli RE(1), Molsberry SA(2), Malave-Ortiz S(3), Calvert M(3), Lucien J(4), 
Denslow S(2), Zaccaro D(2), Kamoun C(5), Shaw ND(6).

Author information:
(1)Division of Pediatric Endocrinology, University of North Carolina School of 
Medicine, Chapel Hill, North Carolina; Pediatric Neuroendocrinology Group, 
Clinical Research Branch, National Institute of Environmental Health Sciences 
(NIEHS), Durham, NC 27709.
(2)Social & Scientific Systems, a DLH Holdings company, Durham, NC 27703.
(3)Pediatric Neuroendocrinology Group, Clinical Research Branch, National 
Institute of Environmental Health Sciences (NIEHS), Durham, NC 27709.
(4)WakeMed Health and Hospitals, Raleigh, NC 27610.
(5)Division of Pediatric Endocrinology, University of North Carolina School of 
Medicine, Chapel Hill, North Carolina.
(6)Pediatric Neuroendocrinology Group, Clinical Research Branch, National 
Institute of Environmental Health Sciences (NIEHS), Durham, NC 27709. Electronic 
address: Natalie.shaw@nih.gov.

STUDY OBJECTIVE: To determine the natural history of menstrual pain without 
pelvic pathology, the role of progesterone in its pathophysiology, and 
associated risk factors in a longitudinal study of early post-menarchal girls in 
North Carolina.
METHODS: Participants contributed daily urine samples for up to 3.5 years to 
measure pregnanediol-3-glucuronide [PdG] (mean 589 urines/participant), 
completed menstrual diaries, and reported menstrual pain using the Menstrual 
Symptom Questionnaire (MSQ) biannually. MSQ scores were log-transformed and 
generalized estimating equations assessed associations with gynecologic age, 
cycle peak PdG, presumed ovulation, physical activity, anxiety, and depression. 
Models were adjusted for age at menarche, baseline body mass index, 
race/ethnicity, parental education and employment, and gynecologic age.
RESULTS: Forty-three girls, aged 12.6 ± 1.1 years (mean ± SD) at enrollment with 
a gynecologic age 0.3 ± 0.2 years, participated. Total MSQ scores were higher 
for every 1-year increase in gynecologic age (MSQ score ratio: 1.12; 95% CI: 
1.08, 1.17; p<0.0001). Overall MSQ (ratio: 1.04; 95% CI: 1.02, 1.06; p=0.0002) 
and abdominal pain-specific (ratio: 1.04; 95% CI: 1.01, 10.7; p=0.004) scores 
were higher for every 1000 ng/mg creatinine increase in peak PdG in the 
preceding cycle. Overall MSQ scores were higher (ratio 1.26; 95% CI: 1.11, 1.44; 
p=0.0005) if the preceding cycle was presumed ovulatory. Menstrual pain was not 
associated with physical activity, anxiety, or depression.
CONCLUSIONS: In early post-menarchal girls, gynecologic age and PdG were 
associated with menstrual pain, suggesting a pathophysiologic role for 
progesterone and other unknown factors in the development of menstrual pain.

Copyright © 2024. Published by Elsevier Inc.

DOI: 10.1016/j.jpag.2024.10.006
PMID: 39505294

Conflict of interest statement: Declaration of competing interest No disclosures 
for authors 1, 2, 3, 4, 5, 6, 7, 8, or 9.


5. J Oral Biosci. 2024 Nov 4:100586. doi: 10.1016/j.job.2024.100586. Online ahead
 of print.

Maxillary sinus floor augmentation using sponge- and cotton-like graft materials 
in a rabbit model.

Ohba S(1), Shido R(2), Yamamoto H(3), Hara M(4), Nishikawa Y(5), Kasuga T(6), 
Yamada T(4), Sumita Y(7), Shirota T(8).

Author information:
(1)Department of Oral and Maxillofacial Surgery, Showa University School of 
Dentistry, 2-1-1 Kitasenzoku, Ota-ku, Tokyo 145-8515, Japan; Department of Oral 
and Maxillofacial Surgery, Nagasaki University Graduate School of Biomedical 
Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan. Electronic address: 
seigoohba@gmail.com.
(2)Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical 
and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 
734-8553, Japan.
(3)Department of Applied Prosthodontics, Graduate School of Biomedical Sciences, 
Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
(4)Department of Oral and Maxillofacial Surgery, Nagasaki University Graduate 
School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
(5)ORTHOREBIRTH Co., Ltd., 15-3-303 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 
Kagnagawa 224-0032, Japan.
(6)Division of Advanced Ceramics, Nagoya Institute of Technology, Gokiso-cho, 
Showa-ku, Nogoya, Aichi 466-8555, Japan.
(7)Department of Medical Research and Development for Oral Disease, Nagasaki 
University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 
852-8588, Japan.
(8)Department of Oral and Maxillofacial Surgery, Showa University School of 
Dentistry, 2-1-1 Kitasenzoku, Ota-ku, Tokyo 145-8515, Japan.

OBJECTIVES: Bone graft materials commonly used for maxillary sinus floor 
augmentation (MSFA), including hydroxyapatite (HAp) and β-tricalcium phosphate 
(β-TCP), are mostly granular and have poor handleability. HAp/collagen composite 
material (HAp/Col) and β-tricalcium phosphate 
(β-TCP)/poly(L-lactide-co-glycolide) (PLGA) have shown promise but their 
application in MSFA as bone graft materials remains unclear. Here, we 
investigated the bone-forming behavior of HAp/Col and β-TCP/PLGA in an MSFA 
rabbit model.
METHODS: Male Japanese white rabbits were used. HAP/Col or β-TCP/PLGA was 
randomly applied to the MSFA model. The specimens were harvested at 4 weeks (W), 
8W, 16W, and 24W after surgery, and the augmented regions were evaluated using 
micro-computed tomography and histological analyses.
RESULTS: The graft materials were retained up to 16W in the HAp/Col group and 
24W in the β-TCP/PLGA group. The augmented volume detected in the HAp/Col group 
at 4W was substantially reduced at subsequent time points. However, in the 
β-TCP/PLGA group, the volume observed at 4W was maintained up to 24W. In the 
HAp/Col group, the bone mineral content (BMC) at 4W was significantly lower than 
that at 8W (p=0.03716), and this elevated BMC was significantly decreased at 16W 
(p=0.00185) and 24W (p=0.00236). In the β-TCP/PLGA group, the BMC tended to 
increase from 4W to 16W and then decreased.
CONCLUSIONS: Both HAp/Col and β-TCP/PLGA are useful for MSFA because of their 
ability to form new bone and good handleability. The appropriate graft material 
should be selected depending on the application needs while understanding the 
properties of the newly formed bone.

Copyright © 2024. Published by Elsevier B.V.

DOI: 10.1016/j.job.2024.100586
PMID: 39505066