Psychoactive Plant Database - Neuroactive Phytochemical Collection

1. J Interpers Violence. 2024 Nov 7:8862605241297314. doi: 
10.1177/08862605241297314. Online ahead of print.

I Belong: Gender and Sexuality Minoritized Students' Positive Perceptions of 
Campus Climate Protect Against PTSD Following Sexual Assault.

Bilal NJ(1), Herres J(1).

Author information:
(1)The College of New Jersey, Ewing, USA.

Sexual assault is a widespread problem among institutions of higher education. 
Students whose gender and/or sexuality are minoritized (GSM; non-cisgender 
and/or non-heterosexual) are especially vulnerable to experiencing sexual 
assault and its negative consequences, including post-traumatic stress disorder 
(PTSD). A sense of belonging within the campus community can protect victims of 
sexual assault from negative psychological outcomes; however, no study to date 
has examined whether this aspect of a positive campus climate protects GSM 
victims, in particular, from developing more severe PTSD symptoms after sexual 
assault. We hypothesized that GSM victims would experience more severe PTSD 
symptoms than non-GSM victims after experiencing sexual assault and that their 
perceptions of campus climate would moderate this relationship. All 
undergraduate students from a public liberal arts college on the East Coast were 
asked to participate in an online survey about their history of sexual assault 
and emotional well-being. Of those who completed the survey, approximately 18% 
reported a history of sexual assault (N = 146). GSM victims of sexual assault 
reported more severe PTSD symptoms than non-GSM victims; however, a significant 
interaction showed that PTSD symptoms were similar for GSM and non-GSM victims 
with high ratings of campus climate. Thus, positive perceptions of campus 
climate protected GSM students from experiencing more severe PTSD symptoms. 
These findings inform administrative efforts by suggesting the need for more 
inclusive support resources (i.e., crisis centers and orientation materials), 
curricula, and community spaces for GSM students.

DOI: 10.1177/08862605241297314
PMID: 39508250

Conflict of interest statement: Declaration of Conflicting InterestsThe 
author(s) declared no potential conflicts of interest with respect to the 
research, authorship, and/or publication of this article.


2. Electrophoresis. 2024 Nov 7. doi: 10.1002/elps.202400122. Online ahead of
print.

A Comprehensive Review on Capillary Electrophoresis-Mass Spectrometry in 
Advancing Biomolecular Research.

Pont L(1)(2), Vergara-Barberán M(3), Carrasco-Correa EJ(3).

Author information:
(1)Department of Chemical Engineering and Analytical Chemistry, Institute for 
Research on Nutrition and Food Safety (INSA·UB), University of Barcelona, 
Barcelona, Spain.
(2)Serra Húnter Program, Generalitat de Catalunya, Barcelona, Spain.
(3)CLECEM Group, Department of Analytical Chemistry, University of Valencia, 
Valencia, Spain.

This review provides an in-depth exploration of capillary electrophoresis-mass 
spectrometry (CE-MS) in biomolecular research from 2020 to 2024. CE-MS emerges 
as a versatile and powerful tool due to its numerous advantages, facilitating 
the analysis of various biomolecules, including proteins, peptides, 
oligonucleotides, and other metabolites, such as lipids, carbohydrates, or 
amines, among others. The review extends to various CE modes and interfaces for 
the CE-MS coupling, offering comprehensive insights into their applications 
within biomolecular research. Furthermore, it effectively summarizes the 
conditions employed in CE-MS while also addressing critical aspects such as 
sample preparation requirements. Despite its advantages, the review highlights a 
gap between discovery and practical implementation, underscoring the need for 
large-scale validation and method standardization to fully realize the potential 
of CE-MS in biomolecular research.

© 2024 The Author(s). Electrophoresis published by Wiley‐VCH GmbH.

DOI: 10.1002/elps.202400122
PMID: 39508247


3. BMC Musculoskelet Disord. 2024 Nov 6;25(1):883. doi:
10.1186/s12891-024-08010-y.

The association between metabolite profiles and impaired bone microstructure in 
adult growth hormone deficient rats.

Guo X(1), Liu S(1), Hu W(1), Lyu X(1), Xu H(1), Zhu H(1), Pan H(1), Wang L(1), 
Wan Y(2), Yang H(3), Gong F(4).

Author information:
(1)Department of Endocrinology, Key Laboratory of Endocrinology of National 
Health Commission, Peking Union Medical College Hospital, Chinese Academy of 
Medical Sciences and Peking Union Medical College, 1# Shuaifuyuan, Wangfujing, 
Beijing, 100730, China.
(2)Department of Physiology, School of Basic Medical Sciences, Wuhan University, 
Wuhan, Hubei, China.
(3)Department of Endocrinology, Key Laboratory of Endocrinology of National 
Health Commission, Peking Union Medical College Hospital, Chinese Academy of 
Medical Sciences and Peking Union Medical College, 1# Shuaifuyuan, Wangfujing, 
Beijing, 100730, China. yanghb@pumch.cn.
(4)Department of Endocrinology, Key Laboratory of Endocrinology of National 
Health Commission, Peking Union Medical College Hospital, Chinese Academy of 
Medical Sciences and Peking Union Medical College, 1# Shuaifuyuan, Wangfujing, 
Beijing, 100730, China. fygong@sina.com.

BACKGROUND: Adult growth hormone deficiency (AGHD) is associated with an 
increased risk of fractures and impaired bone microstructure. Understanding the 
metabolic changes accompanying bone deterioration in AGHD might provide insights 
into mechanisms behind molecular changes and develop new biomarkers or 
nutritional strategies for bone destruction. Our study aimed to investigate the 
association between altered metabolite patterns and impaired bone microstructure 
in adult rats with growth hormone deficiency.
METHODS: Thirty seven-week-aged adult Lewis dwarf homozygous (dw/dw) rats (five 
females and five males), and adult Lewis dwarf heterozygous (dw/ +) rats (five 
females and five males) rats were compared. Micro-computed tomography (Micro-CT) 
was used to examine the bone's microstructure. Hematoxylin and eosin (H&E) 
staining were used to quantify the histological characteristics. Liquid 
chromatography-mass spectrometry untargeted serum metabolomic analysis was 
applied in the study. ELISA was used to measure serum bone turnover markers and 
IGF-1 levels.
RESULTS: Adult dw/dw rats exhibited great reductions in trabecular volume bone 
density (Tb.vBMD), bone volume/total volume (BV/TV), and cortical thickness (Ct. 
Th) compared with adult dw/ + rats (all p values < 0.05), indicating significant 
impairment in bone microstructure. The serum metabolite profiles revealed 
substantial differences between the dw/dw rats and dw/ + rats. A total of 134 
differential metabolites in positive ion mode and 49 differential metabolites in 
negative mode were identified. Five metabolites, including 
Lysophosphatidylcholine(LPC) 20:3, LPC22:6, LPC22:4, cortisol and histamine 
levels were upregulated in dw/dw rats. The steroid hormone biosynthesis and bile 
secretion pathways were the main perturbed metabolic pathways. There were 
significant associations between differential metabolites and the impaired bone 
microstructure parameters, indicating that the selected metabolites might serve 
as potential biomarkers for deteriorated bone microstructure in AGHD.
CONCLUSION: Adult dw/dw rats exhibit impaired bone microstructure and distinct 
serum metabolic profiles, and the altered metabolites were significantly 
associated with bone microstructure destruction. This provides a new insight 
into understanding the mechanism of bone deterioration in AGHD patients from a 
metabolic perspective.

© 2024. The Author(s).

DOI: 10.1186/s12891-024-08010-y
PMID: 39508246


4. Inorg Chem. 2024 Nov 7. doi: 10.1021/acs.inorgchem.4c04050. Online ahead of 
print.

Tuning the Properties of Rigidified Acyclic DEDPA(2-) Derivatives for 
Application in PET Using Copper-64.

Torralba-Maldonado D(1), Marlin A(2), Lucio-Martínez F(3), Freire-García A(3), 
Whetter J(2), Brandariz I(3), Iglesias E(3), Pérez-Lourido P(4), Ortuño RM(1), 
Boros E(2), Illa O(1), Esteban-Gómez D(3), Platas-Iglesias C(3).

Author information:
(1)Departament de Química, Universitat Autònoma de Barcelona, 08193, Cerdanyola 
del Vallès, Spain.
(2)Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 
53706, United States.
(3)Centro Interdisciplinar de Química e Bioloxía (CICA) and Departamento de 
Química, Facultade de Ciencias, Universidade da Coruña, Galicia, 15071 A Coruña, 
Spain.
(4)Departamento de Química Inorgánica, Facultad de Química, Universidade de 
Vigo, As Lagoas, Marcosende, 36310 Pontevedra, Spain.

We present a detailed investigation of the coordination chemistry toward 
[natCu/64Cu]copper of a series of H2DEDPA derivatives (H2DEDPA = 
6,6'-((ethane-1,2-diylbis(azanediyl))bis(methylene))dipicolinic acid) containing 
cyclohexyl (H2CHXDEDPA), cyclopentyl (H2CpDEDPA) or cyclobutyl (H2CBuDEDPA) 
spacers. Furthermore, we also developed a strategy that allowed the synthesis of 
a H2CBuDEDPA analogue containing an additional NHBoc group at the cyclobutyl 
ring, which can be used for conjugation to targeting units. The X-ray structures 
of the Cu(II) complexes evidence distorted octahedral coordination around the 
metal ion in all cases. Cyclic voltammetry experiments (0.15 M NaCl) evidence 
quasi-reversible reduction waves associated with the reduction of Cu(II) to 
Cu(I). The complexes show a high thermodynamic stability, with log KCuL values 
of 25.11(1), 22.18(1) and 20.19(1) for the complexes of CHXDEDPA2-, CpDEDPA2- 
and CBuDEDPA2-, respectively (25 °C, 1 M NaCl). Dissociation kinetics 
experiments reveal that both the spontaneous- and proton-assisted pathways 
operate at physiological pH. Quantitative labeling with 64CuCl2 was observed at 
0.1 nmol for CHXDEDPA2- and CpDEDPA2-, 0.025 nmol for CBuDEDPA2- and 1 nmol for 
CBuDEDPA-NHBoc2-, with no significant differences observed at 15, 30, and 60 
min. The radio-complexes are stable in PBS over a period of 24 h.

DOI: 10.1021/acs.inorgchem.4c04050
PMID: 39508185


5. J Am Heart Assoc. 2024 Nov 7:e036417. doi: 10.1161/JAHA.124.036417. Online
ahead  of print.

Association Between Direct Oral Anticoagulant Score and Bleeding Events in 
Patients With Atrial Fibrillation Following Transcatheter Aortic Valve 
Replacement: A Retrospective Multicenter Cohort Study.

Harano Y(1)(2), Yamamoto M(1)(3)(4), Shimura T(1)(3), Okubo M(1), Koyama Y(1), 
Yamaguchi R(3), Kagase A(4), Tokuda T(4), Yashima F(5), Shirai S(6), Tada N(7), 
Naganuma T(8), Yamawaki M(9), Yamanaka F(10), Mizutani K(11), Noguchi M(12), 
Ueno H(13), Takagi K(14), Ohno Y(15), Izumo M(16), Nishina H(17), Asami M(18), 
Otsuka T(19)(20), Watanabe Y(21), Hayashida K(22); OCEAN‐TAVI investigators †.

Collaborators: Hayashida K, Tanaka M, Tsuruta H, Saito T, Kobari Y, Ryuzaki T, 
Takahashi T, Goto S, Imaeda S, Sakata S, Katsumata Y, Shirakawa K, Iwata J, 
Shinada K, Kajino A, Kato J, Arita R, Moriizumi T, Yamamoto M, Sago M, Tsunaki 
T, Yamaguchi R, Yanagisawa J, Okubo Y, Kagase A, Tokuda T, Nakashima Y, 
Kobayashi T, Shibata K, Kawahata R, Nishio H, Kondo Y, Nakamura T, Tsunamoto H, 
Shimura T, Koyama Y, Okubo M, Imai S, Sakakura T, Harano Y, Inagaki M, Higami H, 
Kuze Y, Nagai T, Kurita A, Shirai S, Isotani A, Ishizu K, Fukunaga M, Tabata H, 
Morofuji T, Kono H, Kuroda M, Euihong K, Miyawaki N, Nakano K, Miyahara K, 
Yamamoto K, Onuki K, Tsuru Y, Suenaga T, Otani A, Watanabe Y, Katayama T, Hioki 
H, Nishikawa J, Iseki Y, Tsuchida Y, Kito K, Omiya J, Arakawa M, Okamoto M, 
Saito M, Miura M, Naganuma T, Ouchi T, Yuki H, Yamawaki M, Tada N, Enta Y, 
Nakashima M, Saigan M, Munehisa Y, Miyasaka M, Satomi N, Kobayashi Y, Tazawa D, 
Teng Y, Yamanaka F, Mizuno S, Shishido K, Ochiai T, Yamabe T, Moriyama N, 
Matsumoto T, Miyashita H, Sugiyama Y, Shimizu K, Sato D, Murakami Y, Noguchi M, 
Kato N, Ito J, Muraishi M, Azumi Y, Tabata M, Yoshino K, Kobayashi T, Sakai H, 
Ueno H, Fukuda N, Tanaka S, Onoda H, Doi T, Sobajima M, Ueno Y, Imamura T, 
Ushijima R, Hida Y, Nakashima K, Ohno Y, Miyamoto J, Murakami T, Okada K, Torii 
S, Natsumeda M, Tanaka S, Ijichi T, Horinouchi H, Aihara K, Sakai K, Matsumoto 
S, Kamioka N, Nakamura N, Saito T, Noda S, Sato Y, Izumo M, Miyahara D, Kuwata 
S, Koga M, Kaihara T, Higuma T, Honda K, Kobayashi Y, Murata R, Sasaki K, 
Togashi D, Kai T, Okuno T, Yoshida T, Sone K, Terauchi K, Yamasaki K, Bota H, 
Tani T, Miyazaki M, Katagiri Y, Nishina H, Kuwayama A, Akiyama D, Shinouchi K, 
Ishikawa M, Suzuyama H, Kodama K, Okamatsu H, Sakamoto T, Horibata Y, Konami Y, 
Yamada M, Horio E, Maeda M, Hasegawa S, Koga M, Ohara M, Fukushige S, Fuku Y, 
Ikuta A, Matsushita S, Oka S, Inoue N, Bando G, Takagi K, Amaki M, Kitai T, 
Okada A, Hada T, Nakagawa S, Arai M, Irie Y, Sakamoto T, Kurashima S, Asami M, 
Tanaka J, Horiuchi Y, Hosoda N, Gonda Y, Nishimura Y, Oshima A, Yashima F, 
Hashizume K, Nishida H, Yoshijima N, Sato M, Nakazawa G, Yasuda M, Fujita K, 
Miyoshi T, Soejima N, Maruyama M, Tanaka M, Kawamura T, Kanno H, Yoshida A, 
Onishi K, Yamada N, Matsuzoe H, Hachinohe D, Kobayashi K, Kaneko U, Mizutani K, 
Shitan H, Horita R, Otake R.

Author information:
(1)Department of Cardiology Gifu Heart Center Gifu Japan.
(2)Department of Cardiology, Faculty of Medicine University of Tsukuba Japan.
(3)Department of Cardiology Toyohashi Heart Center Toyohashi Japan.
(4)Department of Cardiology Nagoya Heart Center Nagoya Japan.
(5)Department of Cardiology Saiseikai Utsunomiya Hospital Tochigi Japan.
(6)Department of Cardiology Kokura Memorial Hospital Kokura Japan.
(7)Department of Cardiology Sendai Kosei Hospital Sendai Japan.
(8)Department of Cardiology New Tokyo Hospital Chiba Japan.
(9)Department of Cardiology Saiseikai Yokohama City Eastern Hospital Yokohama 
Japan.
(10)Department of Cardiology Shonan Kamakura General Hospital Kamakura Kanagawa 
Japan.
(11)Division of Cardiology, Department of Medicine Kindai University Osaka 
Japan.
(12)Department of Cardiology Tokyo Bay Urayasu Ichikawa Medical Center Urayasu 
Japan.
(13)Second Department of Internal Medicine Toyama University Hospital Toyama 
Japan.
(14)Department of Cardiology National Cerebral and Cardiovascular Center Oasaka 
Japan.
(15)Department of Cardiology Tokai University School of Medicine Isehara Japan.
(16)Department of Cardiology St Marianna University School of Medicine Tokyo 
Japan.
(17)Department of Cardiology Tsukuba Medical Center Hospital Tsukuba Japan.
(18)Division of Cardiology Mitsui Memorial Hospital Tokyo Japan.
(19)Department of Hygiene and Public Health Nippon Medical School Tokyo Japan.
(20)Center for Clinical Research Nippon Medical School Hospital Tokyo Japan.
(21)Department of Cardiology Teikyo University School of Medicine Tokyo Japan.
(22)Department of Cardiology Keio University School of Medicine Tokyo Japan.

BACKGROUND: The Direct Oral Anticoagulant (DOAC) Score can predict bleeding risk 
in patients with atrial fibrillation taking DOACs; however, it lacks external 
validation. Therefore, this study aimed to assess the association between the 
DOAC Score and bleeding events in patients with atrial fibrillation who 
underwent transcatheter aortic valve replacement.
METHODS AND RESULTS: This retrospective multicenter cohort study included 
patients with atrial fibrillation who underwent transcatheter aortic valve 
replacement, as registered in a Japanese multicenter registry. The primary end 
point was the incidence of bleeding. Patients were categorized based on their 
DOAC Score: low and moderate- (≤7 points), high- (8-9 points), and very 
high-risk (≥10 points) groups. Among 1230 patients (mean age 84.6±5.1 years; 457 
men), 465 (37.8%) received a vitamin K antagonist, and the remaining patients 
received DOACs. The low and moderate-, high-, and very high-risk groups included 
380 (30.1%), 497 (40.4%), and 353 patients (28.7%), respectively. The 3-year 
cumulative incidence of all bleeding events was significantly different among 
the 3 groups (low and moderate risk: 6.6%, high risk: 6.9%, and very high risk: 
14.0%; P<0.01). Multivariable Cox regression analysis revealed that significant 
increments in the DOAC Score were associated with a risk of all bleeding events 
at 3 years in the overall cohort (hazard ratio [HR], 1.22 [95% CI, 1.08-1.38]; 
P<0.01), in the DOAC cohort (HR, 1.20 [95% CI, 1.01-1.42]; P=0.04), and in the 
vitamin K antagonist cohort (HR, 1.25 [95% CI, 1.04-1.50]; P=0.02).
CONCLUSIONS: The DOAC Score was significantly associated with bleeding events in 
patients with atrial fibrillation after transcatheter aortic valve replacement, 
aiding in clinical decision-making for anticoagulant management.
REGISTRATION: URL: 
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000023585; 
Unique identifier: UMIN000020423.

DOI: 10.1161/JAHA.124.036417
PMID: 39508173