Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. Results Chem. 2021 Sep 24:100199. doi: 10.1016/j.rechem.2021.100199. Online ahead of print. In Silico Investigation of Phytoconstituents of Medicinal Herb 'Piper Longum' Against SARS-CoV-2 by Molecular Docking and Molecular Dynamics Analysis. Lakhera S(1), Devlal K(1), Ghosh A(2), Rana M(1). Author information: (1)Department of Physics, School of Sciences, Uttarakhand Open University, Haldwani, 263139, Uttarakhand, India. (2)Microbiology Division, Department of Botany, Guwahati University, Guwahati, 781014, Assam, India. Unavailability of treatment for the SARS-CoV-2 virus has raised concern among the population worldwide. This has led to many attempts to find alternative options to prevent the infection of the disease, including focusing on vaccines and drugs. The use of natural products and herbal extracts can be a better option in beating the virus and boosting up immunity. In the present paper, we have done a systematic in silico study of papain-like protease of COVID-19 virus with the chemical constituents of herbal plant Piper Longum. Screening of the pharmacokinetic properties is done with thirty-two phytoconstituents of Piper Longum which help us in selecting the most active components of the plant. After selection molecular docking is performed with Aristololactam (C17H11NO4), Fargesin (C21H22O6), l-asarinin (C20H18O6), Lignans Machilin F (C20H22O5), Piperundecalidine (C23H29NO3), and Pluviatilol (C20H20O6). Molecular dynamic (MD) is also performed with the inhibitor-receptor complex which suggest significant inhibition and a stable complex of I-Asarinin with PLpro. Docking scores and simulation results suggest that I-Asarinin can act as a potential drug like candidate against COVID-19. © 2021 Published by Elsevier B.V. DOI: 10.1016/j.rechem.2021.100199 PMCID: PMC8478074 PMID: 34603947 2. J Acupunct Meridian Stud. 2011 Jun;4(2):134-40. doi: 10.1016/S2005-2901(11)60020-4. Overview for various aspects of the health benefits of Piper longum linn. fruit. Kumar S(1), Kamboj J, Suman, Sharma S. Author information: (1)Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, India. pharm.vermasuresh@gmail.com Herbal remedies have become popular, due in part to the lower risk of adverse reactions. Thousands of plants have been used traditionally to treat various diseases. Among them, species of the genus Piper are important medicinal plants used in various systems of medicine. The Piper longum fruit has been used in traditional medicine, including the Ayurvedic system of medicine. Although there are numerous indications for its use, controlled trials are needed to determine its efficacy. The primary constituents isolated from various parts of P. longum are piperine, piperlongumine, sylvatin, sesamin, diaeudesmin piperlonguminine, pipermonaline, and piperundecalidine. It is most commonly used to treat chronic bronchitis, asthma, constipation, gonorrhea, paralysis of the tongue, diarrhea, cholera, chronic malaria, viral hepatitis, respiratory infections, stomachache, bronchitis, diseases of the spleen, cough, and tumors. This study provides detailed information about the P. longum fruit, including phytochemistry, pharmacological profile and safety profile. In view of the commercial, economic, and medicinal importance of the P. longum plant, it is useful for researchers to study the plant in detail. Copyright © 2011 Korean Pharmacopuncture Institute. Published by .. All rights reserved. DOI: 10.1016/S2005-2901(11)60020-4 PMID: 21704957 [Indexed for MEDLINE]