Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. Org Biomol Chem. 2019 Jul 21;17(27):6671-6677. doi: 10.1039/c9ob00764d. Epub 2019 Jun 26. Regioselective oxidation of indoles to 2-oxindoles. Shelar SV(1), Argade NP(1). Author information: (1)Division of Organic Chemistry, National Chemical Laboratory (CSIR), Pune 411 008, India. np.argade@ncl.res.in and Academy of Scientific and Innovative Research (AcSIR), New Delhi 110 025, India. Facile regioselective oxidation of indoles to 2-oxindoles promoted by sulfuric acid adsorbed on silica gel is reported. The demonstrated practical site-selective heterogeneous oxidation reactions conveniently take place with a broad substrate scope and functional group tolerances. The present oxidation strategy is also employed to accomplish the total synthesis of natural products donaxaridine and donaxarine. On the basis of analytical and spectral data it is evidenced that donaxarine stays in equilibrium with its hydrated ring opened form. The structural features essential for this type of oxidation and plausible mechanism are discussed in brief. DOI: 10.1039/c9ob00764d PMID: 31241107