Psychoactive Plant Database - Neuroactive Phytochemical Collection

1. Molecules. 2022 Oct 7;27(19):6657. doi: 10.3390/molecules27196657.

A New 1,3-Benzodioxole Compound from Hypecoum erectum and Its Antioxidant 
Activity.

Xu N(1), Bao W(1), Xin J(1), Xiao H(1), Yu J(1), Xu L(1).

Author information:
(1)Inner Mongolia Key Laboratory of the Natural Products Chemistry and 
Functional Molecular Synthesis, Inner Mongolia Minzu University, Tongliao 
028000, China.

The purpose of this study was to identify the chemical components in aerial 
parts of Hypecoum erectum. A new 1,3-benzodioxole derivative, identified as 
Hypecoumic acid (1), was isolated, together with the three known compounds: 
protopine (2), coptisine (3), and cryptopine (4). Their structures were 
identified based on extensive spectroscopic experiments, including nuclear 
magnetic resonance (NMR) and high-resolution electrospray ionization mass 
spectra (HR-ESI-MS), as well as comparison with those reported in the 
literature. Meanwhile, the in vitro antioxidative activity of all compounds was 
determined using a DPPH-scavenging assay, and compound 1 (IC50 = 86.3 ± 0.2 μM) 
was shown to have moderate antioxidative activity.

DOI: 10.3390/molecules27196657
PMCID: PMC9570887
PMID: 36235194 [Indexed for MEDLINE]

Conflict of interest statement: The authors declare no conflict of interest.


2. Pharmaceuticals (Basel). 2022 May 25;15(6):654. doi: 10.3390/ph15060654.

Network Pharmacology and Bioinformatics Approach Reveals the Multi-Target 
Pharmacological Mechanism of Fumaria indica in the Treatment of Liver Cancer.

Batool S(1), Javed MR(1), Aslam S(1), Noor F(1), Javed HMF(2), Seemab R(1), 
Rehman A(1), Aslam MF(3), Paray BA(4), Gulnaz A(5).

Author information:
(1)Department of Bioinformatics and Biotechnology, Government College University 
Faisalabad (GCUF), Allama Iqbal Road, Faisalabad 38000, Pakistan.
(2)Allied Hospital, Faisalabad 38000, Pakistan.
(3)School of Biological Sciences, University of Edinburgh, Edinburgh P.O. Box 
EH9 3FF, UK.
(4)Department of Zoology, College of Science, King Saud University, P.O. Box 
2455, Riyadh 11451, Saudi Arabia.
(5)College of Pharmacy, Woosuk University, Wanju-gun 55338, Korea.

Liver cancer (LC), a frequently occurring cancer, has become the fourth leading 
cause of cancer mortality. The small number of reported data and diverse spectra 
of pathophysiological mechanisms of liver cancer make it a challenging task and 
a serious economic burden in health care management. Fumaria indica is a 
herbaceous annual plant used in various regions of Asia to treat a variety of 
ailments, including liver cancer. Several in vitro investigations have revealed 
the effectiveness of F. indica in the treatment of liver cancer; however, the 
exact molecular mechanism is still unrevealed. In this study, the network 
pharmacology technique was utilized to characterize the mechanism of F. indica 
on liver cancer. Furthermore, we analyzed the active ingredient-target-pathway 
network and uncovered that Fumaridine, Lastourvilline, N-feruloyl tyramine, and 
Cryptopine conclusively contributed to the development of liver cancer by 
affecting the MTOR, MAPK3, PIK3R1, and EGFR gene. Afterward, molecular docking 
was used to verify the effective activity of the active ingredients against the 
prospective targets. The results of molecular docking predicted that several key 
targets of liver cancer (along with MTOR, EGFR, MAPK3, and PIK3R1) bind stably 
with the corresponding active ingredient of F. indica. We concluded through 
network pharmacology methods that multiple biological processes and signaling 
pathways involved in F. indica exerted a preventing effect in the treatment of 
liver cancer. The molecular docking results also provide us with sound direction 
for further experiments. In the framework of this study, network pharmacology 
integrated with docking analysis revealed that F. indica exerted a promising 
preventive effect on liver cancer by acting on liver cancer-associated signaling 
pathways. This enables us to understand the biological mechanism of the anti 
liver cancer activity of F. indica.

DOI: 10.3390/ph15060654
PMCID: PMC9229061
PMID: 35745580

Conflict of interest statement: The authors declare no conflict of interest.


3. J Ethnopharmacol. 2022 Mar 25;286:114839. doi: 10.1016/j.jep.2021.114839. Epub
 2021 Dec 8.

Shahatra (F.parviflora Lam)- a comprehensive review of its ethnopharmacology, 
phytochemistry and pharmacology.

Jamaldeen FN(1), Sofi G(2), Fahim MFM(3), Aleem M(4), Begum EMGKN(5).

Author information:
(1)Department of Ilmul Advia (Pharmacology), National Institute of Unani 
Medicine, Kottigepalaya, Magadi Main Road, Bengaluru, 560091, India. Electronic 
address: fnairozadeen@iim.cmb.ac.lk.
(2)Department of Ilmul Advia (Pharmacology), National Institute of Unani 
Medicine, Kottigepalaya, Magadi Main Road, Bengaluru, 560091, India. Electronic 
address: sofi114@rediffmail.com.
(3)Department of Tahaffuzi wa Samaji Tibb (Preventive and Social Medicine), 
National Institute of Unani Medicine, Kottigepalaya, Magadi Main Road, 
Bengaluru, 560091, India. Electronic address: fahimfuard@yahoo.com.
(4)Department of Ilmul Advia (Pharmacology), National Institute of Unani 
Medicine, Kottigepalaya, Magadi Main Road, Bengaluru, 560091, India. Electronic 
address: mohdaleem2190@gmail.com.
(5)Department of Ilmul Advia (Pharmacology), National Institute of Unani 
Medicine, Kottigepalaya, Magadi Main Road, Bengaluru, 560091, India. Electronic 
address: emgknbegum85@gmail.com.

ETHNOPHARMACOLOGICAL RELEVANCE: F.parviflora Lam. is a plant widely used in 
traditional medicine systems like Unani, Ayurveda, and folk medicines in Iraq 
and Turkey. It is known as Shahatraj in Arabic, which is derived from Shahatra 
and called Shajaratuddam. In the ancient Unani system, it is called 
Shajaratuddam. The term derived from Sajarat means tree, and Dam means blood 
since it has a potent blood purifier property.
AIM OF THE STUDY: This review focused on comprehensive, updated information on 
the F.parviflora Lam. about the traditional uses, phytochemical and pharmacology 
and provided insights into potential opportunities for future research.
MATERIALS AND METHODS: The classical literature of Shahatra for its temperament 
(Mizaj), medicinal properties and traditional therapeutic uses were gathered 
from nearly 15 classical Unani books, eight local and foreign books on 
ethnomedicines and ethnobotany in English. The information of pharmacognosy, 
phytochemical and pharmacological activities of F.parviflora Lam was collected 
by browsing the Internet (PubMed, ScienceDirect, Wiley online library, Google 
Scholar, ResearchGate). The relevant primary sources were probed, analysed, and 
included in this review. The keywords used to browse were F.parviflora Lam, 
shahatra, pitpapda, and fine fumitory. Relevant Sources were gathered up to 
April 2021, and the chemical structures were drawn using Chemsketch software. 
The species name was checked with http://www.theplantlist.org ("F.parviflora 
Lam. - The Plant List," n.d.). The materials published in both Urdu and English 
were included in the review.
RESULTS: F.parviflora Lam was found to possess an excess of bioactive compounds 
and broad pharmacological properties, including antimicrobial activity, 
antioxidant activity, antiprotozoal activity, anthelmintic activity, 
antidiarrheal, antispasmodic and bronchodilator activities, antidiabetic 
activity, hepatoprotective activity, anticancer activity (cytotoxicity)of 
nanoparticle, antipruritic activity, dermatological effect, reproductive effect, 
anti-inflammatory and anti-nociceptive activity.
CONCLUSION: In this review, the botany, traditional uses, phytochemistry and 
pharmacology of F.parviflora were reviewed. It showed a broad scope of 
application, and its benefits had been extended far beyond the initial 
conventional uses of its parts. It consists of numerous chemical constituents 
and reported various pharmacological activities such as antimicrobial activity, 
antioxidant activity, antidiabetic activity, hepatoprotective activity, 
anticancer activity etc. Though it is widely studied using several in-vitro and 
in-vivo models and tested clinically for skin diseases, several gaps and 
research priorities have been identified that need to be addressed in the 
future, such as active ingredients and their mechanism of action applications in 
immunomodulation and hepatic diseases.

Copyright © 2021 Elsevier B.V. All rights reserved.

DOI: 10.1016/j.jep.2021.114839
PMID: 34896208 [Indexed for MEDLINE]


4. Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1758-1763. doi: 
10.19540/j.cnki.cjcmm.20180115.014.

[Chemical constituents from a Tibetan herbal medicine Corydalis hendersonii].

[Article in Chinese]

Yin X(1), Zhang Q(2), Zhang HX(1), Wuken SN(1), Li JJ(1), Jiao SG(1), Yang 
FQ(2), Tu PF(1), Chai XY(1).

Author information:
(1)Modern Research Center for Traditional Chinese Medicine, School of Chinese 
Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
(2)School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 
401331, China.

Nine alkaloids and two phenolic glycosides were isolated from EtOH extract of 
the whole plants of Corydalis hendersonii by various chromatographic techniques 
including silica gel, ODS, Sephadex LH-20, and semi-preparative HPLC. Their 
structures were identified as groenlandicine (1), berberine (2), protopine (3), 
cryptopine (4), N-trans-feruloyloctopamine(5), 
3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)-2-methoxyethyl] acrylamide 
(6), N-cis-p-coumaroyloctopamine (7), N-trans-p-coumaroylnoradrenline 
(8),N-cis-feruloyloctopamine (9), apocynin (10), and glucoacetosyringone (11) by 
the spectroscopic data analysis and comparison with those in the literature. 
Among them, compounds 10 and 11 were isolated from this genus for the first 
time, and 1, 2, and 5-9 were isolated from the species for the first time. All 
isolates were tested for their protection for in vitro PC12 cell line and 
antiplatelet aggregation activity. The results showed that compounds 5 and 7 
displayed protective effects at a concentration of 10 μmol·L⁻¹, and compound 2 
showed antiplatelet aggregation activity induced by THR, ADP, and AA, and 
compound 3 exhibted inhibitory effect induced by THR.

Copyright© by the Chinese Pharmaceutical Association.

DOI: 10.19540/j.cnki.cjcmm.20180115.014
PMID: 29902882 [Indexed for MEDLINE]

Conflict of interest statement: The authors of this article and the planning 
committee members and staff have no relevant financial relationships with 
commercial interests to disclose.


5. Z Naturforsch C J Biosci. 2016;71(1-2):9-14. doi: 10.1515/znc-2014-4179.

Alkaloid profiles and acetylcholinesterase inhibitory activities of Fumaria 
species from Bulgaria.

Vrancheva RZ, Ivanov IG, Aneva IY, Dincheva IN, Badjakov IK, Pavlov AI.

GC-MS analysis of alkaloid profiles of five Fumaria species, naturally grown in 
Bulgaria (F. officinalis, F. thuretii, F. kralikii, F. rostellata and F. 
schrammii) and analysis of acetylcholinesterase inhibitory activity of alkaloid 
extracts were performed. Fourteen isoquinoline alkaloids were identified, with 
the principle ones being protopine, cryptopine, sinactine, parfumine, 
fumariline, fumarophycine, and fumaritine. Protopine contents, defined by HPLC 
analysis varied between 210.6 ± 8.8 μg/g DW (F. schrammii) and 334.5 ± 7.1 μg/g 
DW. (F. rostellata). While all of the investigated alkaloid extracts 
significantly inhibited acetylcholinesterase activity, the F. kralikii 
demonstrated the highest level of inhibition (IC(50) 0.13 ± 0.01 mg extract/mL).

DOI: 10.1515/znc-2014-4179
PMID: 26756091 [Indexed for MEDLINE]