Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. J Nat Prod. 2015 Oct 23;78(10):2346-54. doi: 10.1021/acs.jnatprod.5b00252. Epub 2015 Oct 13. Alkaloids from Pandanus amaryllifolius: Isolation and Their Plausible Biosynthetic Formation. Tsai YC(1), Yu ML(1), El-Shazly M(1)(2), Beerhues L(3), Cheng YB(1), Chen LC(4), Hwang TL(5), Chen HF(6), Chung YM(1), Hou MF(7), Wu YC(1)(8)(9)(10), Chang FR(1)(7)(11)(12). Author information: (1)Graduate Institute of Natural Products, Kaohsiung Medical University , Kaohsiung 807, Taiwan. (2)Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University , Organization of African Unity Street, Abassia, Cairo 11566, Egypt. (3)Institut fur Pharmazeutische Biologie, Technische Universitat Braunschweig , Mendelssohnstrasse 1, D-38106 Braunschweig, Germany. (4)Department of Nutrition, I-Shou University , Kaohsiung 840, Taiwan. (5)Graduate Institute of Natural Products, College of Medicine, Chang Gung University , Taoyuan 333, Taiwan. (6)Department of Medical and Applied Chemistry, Kaohsiung Medical University , Kaohsiung 807 Taiwan. (7)Cancer Center, Kaohsiung Medical University Hospital , Kaohsiung 807, Taiwan. (8)Chinese Medicine Research and Development Center, China Medical University Hospital , Taichung 404, Taiwan. (9)Center for Molecular Medicine, China Medical University Hospital , Taichung 404, Taiwan. (10)School of Chinese Medicine, College of Chinese Medicine, China Medical University , Taichung 404, Taiwan. (11)Research Center for Natural Product and New Drug, Kaohsiung Medical University , Kaohsiung 807, Taiwan. (12)Department of Marine Biotechnology and Resources, National Sun Yat-sen University , Kaohsiung 804, Taiwan. Pandanus amaryllifolius Roxb. (Pandanaceae) is used as a flavor and in folk medicine in Southeast Asia. The ethanolic crude extract of the aerial parts of P. amaryllifolius exhibited antioxidant, antibiofilm, and anti-inflammatory activities in previous studies. In the current investigation, the purification of the ethanolic extract yielded nine new compounds, including N-acetylnorpandamarilactonines A (1) and B (2); pandalizines A (3) and B (4); pandanmenyamine (5); pandamarilactones 2 (6) and 3 (7), and 5(E)-pandamarilactonine-32 (8); and pandalactonine (9). The isolated alkaloids, with either a γ-alkylidene-α,β-unsaturated-γ-lactone or γ-alkylidene-α,β-unsaturated-γ-lactam system, can be classified into five skeletons including norpandamarilactonine, indolizinone, pandanamine, pandamarilactone, and pandamarilactonine. A plausible biosynthetic route toward 1-5, 7, and 9 is proposed. DOI: 10.1021/acs.jnatprod.5b00252 PMID: 26461164 [Indexed for MEDLINE]