Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. J Nat Med. 2022 Mar;76(2):482-489. doi: 10.1007/s11418-021-01593-z. Epub 2022 Jan 18. Thannilignan glucoside and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative, two new compounds isolated from Terminalia bellirica. Manome T(1), Hara Y(2)(3), Ahmed F(4), Sadhu SK(5), Ishibashi M(6)(7). Author information: (1)Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan. (2)Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan. yhara@chiba-u.jp. (3)Plant Molecular Science Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan. yhara@chiba-u.jp. (4)Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, 1000, Bangladesh. (5)Pharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh. (6)Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan. mish@chiba-u.jp. (7)Plant Molecular Science Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan. mish@chiba-u.jp. Two new compounds, thannilignan 9-O-β-glucoside (1) and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative (2), and seven known compounds were isolated from the methanol extract of Terminalia bellirica leaves, collected in Bangladesh. The structures of the compounds were elucidated using spectroscopic analysis. Among these isolated compounds, corilagin (3) was cytotoxic against human gastric adenocarcinoma cell line AGS at an IC50 of 20.8 μM, and β-D-glucopyranose 1,3,6-trigallate (4) exhibited the ability to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance. © 2021. The Japanese Society of Pharmacognosy. DOI: 10.1007/s11418-021-01593-z PMID: 35040087 [Indexed for MEDLINE] 2. J Nat Prod. 1997 Jul;60(7):739-42. doi: 10.1021/np970010m. New anti-HIV-1, antimalarial, and antifungal compounds from Terminalia bellerica. Valsaraj R(1), Pushpangadan P, Smitt UW, Adsersen A, Christensen SB, Sittie A, Nyman U, Nielsen C, Olsen CE. Author information: (1)Division of Ethnopharmacology, Tropical Botanic Garden and Research Institute, Kerala, India. A bioactivity-guided fractionation of an extract of Terminalia bellerica fruit rind led to the isolation of two new lignans named termilignan (1) and thannilignan (2), together with 7-hydroxy-3',4'-(methylenedioxy)flavan (3) and anolignan B (4). All four compounds possessed demonstrable anti-HIV-1, antimalarial, and antifungal activity in vitro. DOI: 10.1021/np970010m PMID: 9249982 [Indexed for MEDLINE]