Psychoactive Plant Database - Neuroactive Phytochemical Collection

1. Nat Commun. 2024 Jul 12;15(1):5876. doi: 10.1038/s41467-024-50237-9.

High-efficiency dysprosium-ion extraction enabled by a biomimetic nanofluidic 
channel.

Xin W(1), Cui Y(1), Qian Y(1), Liu T(1), Kong XY(2)(3)(4)(5), Ling H(1)(6), Chen 
W(1), Zhang Z(1)(6), Hu Y(1), Jiang L(1)(6)(7)(8), Wen L(9)(10)(11)(12)(13).

Author information:
(1)CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, 
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 
Beijing, 100190, PR China.
(2)CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, 
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 
Beijing, 100190, PR China. kongxiangyu@mail.ipc.ac.cn.
(3)School of Future Technology, University of Chinese Academy of Sciences, 
Beijing, 100049, PR China. kongxiangyu@mail.ipc.ac.cn.
(4)School of Chemistry and Materials Science, University of Science and 
Technology of China, Hefei, Anhui, 230026, PR China. kongxiangyu@mail.ipc.ac.cn.
(5)Suzhou Institute for Advanced Research, University of Science and Technology 
of China, Suzhou, Jiangsu, 215123, PR China. kongxiangyu@mail.ipc.ac.cn.
(6)School of Future Technology, University of Chinese Academy of Sciences, 
Beijing, 100049, PR China.
(7)School of Chemistry and Materials Science, University of Science and 
Technology of China, Hefei, Anhui, 230026, PR China.
(8)Suzhou Institute for Advanced Research, University of Science and Technology 
of China, Suzhou, Jiangsu, 215123, PR China.
(9)CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, 
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 
Beijing, 100190, PR China. wen@mail.ipc.ac.cn.
(10)School of Future Technology, University of Chinese Academy of Sciences, 
Beijing, 100049, PR China. wen@mail.ipc.ac.cn.
(11)School of Chemistry and Materials Science, University of Science and 
Technology of China, Hefei, Anhui, 230026, PR China. wen@mail.ipc.ac.cn.
(12)Suzhou Institute for Advanced Research, University of Science and Technology 
of China, Suzhou, Jiangsu, 215123, PR China. wen@mail.ipc.ac.cn.
(13)Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of 
Sciences, Qingdao, 266101, PR China. wen@mail.ipc.ac.cn.

Biological ion channels exhibit high selectivity and permeability of ions 
because of their asymmetrical pore structures and surface chemistries. Here, we 
demonstrate a biomimetic nanofluidic channel (BNC) with an asymmetrical 
structure and glycyl-L-proline (GLP) -functionalization for ultrafast, 
selective, and unidirectional Dy3+ extraction over other lanthanide (Ln3+) ions 
with very similar electronic configurations. The selective extraction mainly 
depends on the amplified chemical affinity differences between the Ln3+ ions and 
GLPs in nanoconfinement. In particular, the conductivities of Ln3+ ions across 
the BNC even reach up to two orders of magnitude higher than in a bulk solution, 
and a high Dy3+/Nd3+ selectivity of approximately 60 could be achieved. The 
designed BNC can effectively extract Dy3+ ions with ultralow concentrations and 
thereby purify Nd3+ ions to an ultimate content of 99.8 wt.%, which contribute 
to the recycling of rare earth resources and environmental protection. 
Theoretical simulations reveal that the BNC preferentially binds to Dy3+ ion due 
to its highest affinity among Ln3+ ions in nanoconfinement, which attributes to 
the coupling of ion radius and coordination matching. These findings suggest 
that BNC-based ion selectivity system provides alternative routes to achieving 
highly efficient lanthanide separation.

© 2024. The Author(s).

DOI: 10.1038/s41467-024-50237-9
PMCID: PMC11245470
PMID: 38997277 [Indexed for MEDLINE]

Conflict of interest statement: The authors declare no competing interests.


2. Bull Exp Biol Med. 2022 Jan;172(3):310-313. doi: 10.1007/s10517-022-05400-x. 
Epub 2022 Jan 10.

Preclinical Pharmacokinetics of GZK-111, a Dipeptide with Neuroprotective 
Activity.

Litvin AA(1), Kolyvanov GB(2), Bochkov PO(2), Shevchenko RV(2), Podol'ko AL(2), 
Kolyasnikova KN(2), Zherdev VP(2).

Author information:
(1)Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of 
Pharmacology, Moscow, Russia. litbiopharm@yandex.ru.
(2)Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of 
Pharmacology, Moscow, Russia.

We studied the pharmacokinetics of GZK-111 (N-phenylacetyl-glycyl-L-proline 
ethyl ether), a compound with neuroprotective activity, and its metabolite CPG 
(cyclo-L-prolylglycine) in rat blood plasma after single intravenous and 
intragastric administration in a dose of 20 mg/kg. It was found that the parent 
drug undergoes intensive biotransformation; its metabolite CPG persists in the 
circulation more than twice as long as GZK-111 and its plasma concentrations 
were higher by 50-70 times than the concentrations of the parent compound.

© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

DOI: 10.1007/s10517-022-05400-x
PMID: 35006488 [Indexed for MEDLINE]


3. Arch Microbiol. 2021 Nov;203(9):5763-5782. doi: 10.1007/s00203-021-02520-2.
Epub  2021 Sep 12.

GCMS and FTIR spectral analysis of aqueous methylparathion biotransformation by 
the microbial mpd strains of Pseudomonas aeruginosa and Fusarium spp.

Krishnaswamy U(1)(2).

Author information:
(1)Department of Environmental Sciences, Environmental Microbiology Division, 
Bharathiar University, Coimbatore, TN, India. usharaniks2003@yahoo.com.
(2)Department of Environmental Science, PSG College of Arts and Science, 
Coimbatore, TN, India. usharaniks2003@yahoo.com.

This study aimed to find out the effective biotreatment processes of aqueous 
methyl parathion in stipulations of its biotransformation by potential 
indigenous mpd strains of Pseudomonas aeruginosa and Fusarium spp. Microbial 
biotransformation study of methyl parathion in contaminated synthetic wastewater 
at optimum conditions by P. aeruginosa mpd-5 (at temperature 33 °C, pH 7, under 
the aerobic condition with inoculum density of 108cells/mL) and by Fusarium spp 
mpd-1 (at temperature 30 °C, pH 7, under the aerobic condition with inoculum 
density of 25 mgL-1 dry biomass) was carried out. The major biodegradation 
compounds formed during the biotreatment process were analyzed by spectral 
studies using GCMS and FTIR. GCMS analysis of bacterial transformed compounds 
was p-nitrophenol, dimethylaminophenol, and glycyl-L-proline of 
2-(3-methylpiperidino-4-5, 6-benzothiazin-4-one) and 2, 5-piperazinodione 3, 
6-bis (2-methylpropyl). And the fungal transformed compounds were observed to be 
p-nitrophenol, phenol,2,4-Bis(1,1-Dimethylethyl), 
beta-L-arabinopyranoside-methyl, Cyclobutanethiol, 3-2(4)-thiophenone, 
dihydro-5-(1-methylethyl), Benzene,1,3-bis(1,1-dimethyl ethyl), Butanoic acid, 
2-methyl methyl ester, and L-(+)-Ascorbic acid. The FTIR spectra of the molecule 
and the products of methyl parathion are observed to be changed in structures. 
It can be concluded from the aforementioned results and discussions that P. 
aeruginosa mpd-5 and Fusarium spp mpd-1 can be used in the biotreatment of 
pesticide wastewater having the high methyl parathion concentration and is 
possible by the indigenous microbial strains; they utilize as phosphate and 
carbon source of energy. Hence the strains can be used as a whole microbial 
cell, or its bioactive metabolites can be applied for the biotreatment of 
pesticide wastewater and potentially degrade methylparathion.

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
part of Springer Nature.

DOI: 10.1007/s00203-021-02520-2
PMID: 34510232 [Indexed for MEDLINE]


4. Biochem Biophys Res Commun. 2018 Feb 5;496(2):267-273. doi: 
10.1016/j.bbrc.2017.11.203. Epub 2017 Dec 30.

Low levels of serum serotonin and amino acids identified in migraine patients.

Ren C(1), Liu J(2), Zhou J(2), Liang H(2), Wang Y(3), Sun Y(4), Ma B(5), Yin 
Y(6).

Author information:
(1)Departments of Human Anatomy, Histology and Embryology, Peking University 
Health Science Center, Beijing 100191, China.
(2)Institute of Systems Biomedicine, Department of Pathology, School of Basic 
Medical Sciences, Peking University Health Science Center, Beijing 100191, 
China.
(3)Department of Neurology, Dongzhimen Hospital Affiliated to Beijing University 
of Chinese Medicine, Beijing 100700, China.
(4)Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, 
Beijing 100078, China.
(5)Department of Neurology, Dongzhimen Hospital Affiliated to Beijing University 
of Chinese Medicine, Beijing 100700, China. Electronic address: 
mabin0352@126.com.
(6)Institute of Systems Biomedicine, Department of Pathology, School of Basic 
Medical Sciences, Peking University Health Science Center, Beijing 100191, 
China; Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, 
Beijing 100078, China; Peking-Tsinghua Center for Life Sciences, Beijing 100191, 
China. Electronic address: yinyuxin@bjmu.edu.cn.

Migraine is a highly disabling primary headache associated with a high 
socioeconomic burden and a generally high prevalence. The clinical management of 
migraine remains a challenge. This study was undertaken to identify potential 
serum biomarkers of migraine. Using Liquid Chromatography coupled to Mass 
Spectrometry (LC-MS), the metabolomic profile of migraine was compared with 
healthy individuals. Principal component analysis (PCA) and Orthogonal partial 
least squares-discriminant analysis (orthoPLS-DA) showed the metabolomic profile 
of migraine is distinguishable from controls. Volcano plot analysis identified 
10 serum metabolites significantly decreased during migraine. One of these was 
serotonin, and the other 9 were amino acids. Pathway analysis and enrichment 
analysis showed tryptophan metabolism (serotonin metabolism), arginine and 
proline metabolism, and aminoacyl-tRNA biosynthesis are the three most 
prominently altered pathways in migraine. ROC curve analysis indicated 
Glycyl-l-proline, N-Methyl-dl-Alanine and l-Methionine are potential sensitive 
and specific biomarkers for migraine. Our results show Glycyl-l-proline, 
N-Methyl-dl-Alanine and l-Methionine may be as specific or more specific for 
migraine than serotonin which is the traditional biomarker of migraine. We 
propose that therapeutic manipulation of these metabolites or metabolic pathways 
may be helpful in the prevention and treatment of migraine.

Copyright © 2018 Elsevier Inc. All rights reserved.

DOI: 10.1016/j.bbrc.2017.11.203
PMID: 29294327 [Indexed for MEDLINE]


5. Nat Prod Commun. 2017 Mar;12(3):379-383.

Toward the Synthesis and Pharmacological Screening of a Natural 
Cycloheptapeptide of Plant Origin.

Dahiya R, Singh S.

The solution-phase synthesis of a proline and glycine-rich plant-derived cyclic 
heptapeptide, gypsophin E (8), is reported via coupling of a tetrapeptide unit 
Glycyl-L-leucyl-L-valyl-L-proline-OMe with a tripeptide unit 
Boc-L-isoleucyl-glycyl-L-proline-OH, followed by cyclization of the linear 
fragment having seven amino acid units. The structure of the newly synthesized 
cycloheptapeptide was confirmed by means of chemical and spectroscopic methods. 
The newly synthesized cyclopolypeptide displayed potent antifungal and 
anthelmintic activities against the pathogenic yeast Candida albicans, the 
dermatophytes Trichophyton mentagrophytes and Microsporum audouinii at the 6 
μg/mL level, and the earthworms Megascoplex konkanensis, Pontoscotex corethruses 
and - - Eudrilus eugeniea at a concentration of 2 mg/mL.

PMID: 30549890 [Indexed for MEDLINE]