Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. J Org Chem. 2019 Sep 20;84(18):11935-11944. doi: 10.1021/acs.joc.9b01796. Epub 2019 Aug 28. Synthesis of the Tetracyclic Cores of the Integrastatins, Epicoccolide A and Epicocconigrone A. Jeong JY(1), Sperry J(1), Brimble MA(1). Author information: (1)School of Chemical Sciences , The University of Auckland , 23 Symonds Street, Auckland CBD , Auckland 1010 , New Zealand. The integrastatins, epicoccolide A and epicoccongirone A, are natural products containing a unique [6.6.6.6]-tetracyclic core framework that exhibit a broad spectrum of biological activities. A synthesis of the common core of epicoccolide A and epicocconigrone A has been achieved using an umpolung alkylation-lactonization to assemble an isochromanone from which the bridged 1,3-dioxane was readily assembled. A different strategy was required to access the core on the integrastatins; an initial aryllithium addition to an aldehyde, followed by oxidation and treatment of the masked dihydroxyketone with acid gave the desired core structure. DOI: 10.1021/acs.joc.9b01796 PMID: 31416308 [Indexed for MEDLINE] 2. Org Lett. 2016 Feb 5;18(3):612-5. doi: 10.1021/acs.orglett.5b03707. Epub 2016 Jan 27. o-Quinone Methides via Oxone-Mediated Benzofuran Oxidative Dearomatization and Their Intramolecular Cycloaddition with Carbonyl Groups: An Expeditious Construction of the Central Tetracyclic Core of Integrastatins, Epicoccolide A, and Epicocconigrone A. More AA(1), Ramana CV(1). Author information: (1)Division of Organic Chemistry, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune 411 008, India. The intramolecular cycloaddition of o-quinone methides (o-QMs) with a carbonyl group has been envisaged and executed successfully in the context of constructing the complex and rare [6,6,6,6]-tetracyclic core found in the integrastatins, epicoccolide A, and epicocconigrone A. These transient o-QMs were generated easily from the oxidative dearomatization of the corresponding C2-(aryl)benzofuran by employing Oxone in acetone-water at rt. The subsequent cycloaddition with the carbonyl (or conjugated olefin) present on the C2-aryl group was spontaneous. DOI: 10.1021/acs.orglett.5b03707 PMID: 26815222 [Indexed for MEDLINE]