Psychoactive Plant Database - Neuroactive Phytochemical Collection

1. Int J Biol Macromol. 2024 Sep 23;280(Pt 3):135926. doi: 
10.1016/j.ijbiomac.2024.135926. Online ahead of print.

1-Tetradecanol phase change material microcapsules coating on cotton fabric for 
enhanced thermoregulation.

Dubey I(1), Kadam V(2), Babel S(3), Jose S(4), Kumar A(4).

Author information:
(1)Textile Manufacture and Textile Chemistry Division, ICAR-Central Sheep and 
Wool Research Institute, Avikanagar, Rajasthan 304501, India; College of 
Community and Applied Sciences, Maharana Pratap University of Agriculture and 
Technology, Udaipur, Rajasthan 313001, India.
(2)Textile Manufacture and Textile Chemistry Division, ICAR-Central Sheep and 
Wool Research Institute, Avikanagar, Rajasthan 304501, India. Electronic 
address: vinod.kadam@icar.gov.in.
(3)College of Community and Applied Sciences, Maharana Pratap University of 
Agriculture and Technology, Udaipur, Rajasthan 313001, India.
(4)Textile Manufacture and Textile Chemistry Division, ICAR-Central Sheep and 
Wool Research Institute, Avikanagar, Rajasthan 304501, India.

Rising climate change and extreme weather conditions underpin thermoregulation 
limitations of conventional textiles. This study investigates enhancing the 
thermal properties of cotton fabric by incorporating synthesized 1-tetradecanol 
(TD) phase change material (PCM) microcapsules. Characterization of the TD 
microcapsules was performed using dynamic light scattering (DLS), scanning 
electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), Fourier 
transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and 
differential scanning calorimetry (DSC). The microcapsules (average size of 
0.49 μm) displayed a melting enthalpy (∆Hm) of 105 J·g-1 and a crystallization 
enthalpy (∆Hc) of 51 J·g-1. The microcapsules were mixed with the acrylic binder 
in three different ratios (75:25, 50:50, and 25:75). Hydrothermal, 
knife-over-roll, and pad-dry-cure methods were employed for coating 
microcapsules to cotton fabric. Microcapsule coating on cotton fabric using 
hydrothermal coating with a 75:25 microcapsule binder ratio achieved the highest 
add-on (55 %) and good durability after 25 home washes. The thermal insulation 
R-value of the coated fabric was enhanced (0.0029 m2 K·W-1) at 40 °C. The 
real-time test showed a temperature difference of 2.8 °C and thermal imaging 
displayed lower emissivity for TD-coated fabric. The TD microcapsule coating 
offers a promising method for developing climate-responsive textiles, enhancing 
thermal comfort, and reducing energy consumption in heating and cooling systems.

Copyright © 2024. Published by Elsevier B.V.

DOI: 10.1016/j.ijbiomac.2024.135926
PMID: 39322170

Conflict of interest statement: Declaration of competing interest The authors 
have declared that no conflict of interest exists.


2. Biomater Adv. 2024 Nov;164:213996. doi: 10.1016/j.bioadv.2024.213996. Epub
2024  Aug 10.

Tetradecanol-wrapped, CpG-loaded porous Prussian blue nanoimmunomodulator for 
photothermal-responsive in situ anti-tumor vaccine-like immunotherapy.

Yin C(1), Xing Y(1), Zhao P(1), Yin Y(1), Yao H(1), Xue J(1), Gu W(2).

Author information:
(1)School of pharmaceutical sciences, Capital medical university, Beijing 
100069, PR China.
(2)School of pharmaceutical sciences, Capital medical university, Beijing 
100069, PR China. Electronic address: weigu@ccmu.edu.cn.

Therapeutic vaccine becomes a promising strategy to fight cancer by enhancing 
and sustaining specific anti-tumor immune responses. However, its efficacy is 
often impeded by low immunogenicity, the immunosuppressive tumor 
microenvironment (TME), and immune-related adverse events. Herein, we introduce 
1-tetradecanol (TD)-wrapped, CpG-loaded porous Prussian blue nanoparticles 
(pPBNPs-CpG@TD) as a nanoimmunomodulator to initiate photothermal-induced 
immunogenic cell death (ICD) and photothermal-responsive release of CpG for 
augmenting the ICD effect. It was revealed that the dual-photothermal action 
significantly potentiated the in situ anti-tumor vaccine-like immunotherapy in 
terms of enhanced immunogenicity, promoted dendritic cell maturation, and 
increased T lymphocyte infiltration, consequently eliciting a robust immune 
response for inhibiting both primary and rechallenge tumors on a subcutaneous 
4T1 tumor-bearing mouse model. The development and use of photoactive 
nanoimmunomodulators represents a novel and effective strategy to boost 
immunogenicity and counteract immunosuppressive TME, marking a significant 
advancement in the realm of ICD-driven in situ anti-tumor vaccine-like 
immunotherapy.

Copyright © 2024 Elsevier B.V. All rights reserved.

DOI: 10.1016/j.bioadv.2024.213996
PMID: 39146604 [Indexed for MEDLINE]

Conflict of interest statement: Declaration of competing interest The authors 
declare no competing financial interest.


3. Mycologia. 2024 Sep-Oct;116(5):673-693. doi: 10.1080/00275514.2024.2363730.
Epub  2024 Jul 18.

Decoding host cell interaction- and fluconazole-induced metabolic alterations 
and drug resistance in Candida auris.

Ismail SHH(1)(2), Hamdy R(1)(3), Altaie AM(1), Fayed B(1)(4), Dakalbab S(1)(5), 
El-Awady R(1)(2), Soliman SSM(1)(2).

Author information:
(1)Research Institute for Medical and Health Sciences, University of Sharjah, 
P.O. Box 27272, Sharjah, United Arab Emirates.
(2)College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, United 
Arab Emirates.
(3)Faculty of Pharmacy, Zagazig University, P.O. Box 44519, Zagazig, Egypt.
(4)Department of Chemistry of Natural and Microbial Product, National Research 
Centre, P.O. Box 12622, Cairo, Egypt.
(5)College of Medicine, University of Sharjah, P.O. Box 27272, Sharjah, United 
Arab Emirates.

Candida auris is an emerging drug-resistant pathogen associated with high 
mortality rates. This study aimed to explore the metabolic alterations and 
associated pathogenesis and drug resistance in fluconazole-treated Candida 
auris-host cell interaction. Compared with controls, secreted metabolites from 
fluconazole-treated C. auris and fluconazole-treated C. auris-host cell 
co-culture demonstrated notable anti-Candida activity. Fluconazole caused 
significant reductions in C. auris cell numbers and aggregated phenotype. 
Metabolites produced by C. auris with potential fungal colonization, invasion, 
and host immune evasion effects were identified. Metabolites known to enhance 
biofilm formation produced during C. auris-host cell interaction were inhibited 
by fluconazole. Fluconazole enhanced the production of metabolites with biofilm 
inhibition activity, including behenyl alcohol and decanoic acid. Metabolites 
with potential Candida growth inhibition activity such as 2-palmitoyl glycerol, 
1-tetradecanol, and 1-nonadecene were activated by fluconazole. Different 
patterns of proinflammatory cytokine expression presented due to fluconazole 
concentration and host cell type (fibroblasts versus macrophages). This 
highlights the immune response's complexity, emphasizing the necessity for 
additional research to comprehend cell-type-specific responses to antifungal 
therapies. Both host cell interaction and fluconazole treatment increased the 
expression of CDR1 and ERG11 genes, both associated with drug resistance. This 
study provides insights into pathogenesis in C. auris due to host cell 
interaction and fluconazole treatment. Understanding these interactions is 
crucial for enhancing fluconazole sensitivity and effectively combating C. 
auris.

DOI: 10.1080/00275514.2024.2363730
PMID: 39024116 [Indexed for MEDLINE]


4. Molecules. 2024 Jun 19;29(12):2914. doi: 10.3390/molecules29122914.

Preliminary Screening on Antibacterial Crude Secondary Metabolites Extracted 
from Bacterial Symbionts and Identification of Functional Bioactive Compounds by 
FTIR, HPLC and Gas Chromatography-Mass Spectrometry.

Chandrakasan G(1), García-Trejo JF(1), Feregrino-Pérez AA(1), Aguirre-Becerra 
H(1), García ER(1), Nieto-Ramírez MI(1).

Author information:
(1)División de Estudios de Posgrado, Facultad de Ingeniería, Universidad 
Autónoma de Querétaro, Santiago de Querétaro 76010, Querétaro, Mexico.

Secondary metabolites, bioactive compounds produced by living organisms, can 
unveil symbiotic relationships in nature. In this study, soilborne 
entomopathogenic nematodes associated with symbiotic bacteria (Xenorhabdus 
stockiae and Photorhabdus luminescens) were extracted from solvent supernatant 
containing secondary metabolites, demonstrating significant inhibitory effects 
against E. coli, S. aureus, B. subtilus, P. mirabilis, E. faecalis, and P. 
stutzeri. The characterization of these secondary metabolites by Fourier 
transforms infrared spectroscopy revealed amine groups of proteins, hydroxyl and 
carboxyl groups of polyphenols, hydroxyl groups of polysaccharides, and carboxyl 
groups of organic acids. Furthermore, the obtained crude extracts were analyzed 
by high-performance liquid chromatography for the basic identification of 
potential bioactive peptides. Gas chromatography-mass spectrometry analysis of 
ethyl acetate extracts from Xenorhabdus stockiae identified major compounds 
including nonanoic acid derivatives, proline, paromycin, octodecanal 
derivatives, trioxa-5-aza-1-silabicyclo, 4-octadecenal, methyl ester, oleic 
acid, and 1,2-benzenedicarboxylicacid. Additional extraction from Photorhabdus 
luminescens yielded functional compounds such as indole-3-acetic acid, phthalic 
acid, 1-tetradecanol, nemorosonol, 1-eicosanol, and unsaturated fatty acids. 
These findings support the potential development of novel natural antimicrobial 
agents for future pathogen suppression.

DOI: 10.3390/molecules29122914
PMCID: PMC11206551
PMID: 38930979 [Indexed for MEDLINE]

Conflict of interest statement: The authors declare no conflicts of interest. 
The funders had no role in the design of the study; in the collection, analyses, 
or interpretation of data; in the writing of the manuscript; or in the decision 
to publish the results.


5. J Insect Sci. 2024 May 1;24(3):23. doi: 10.1093/jisesa/ieae060.

Electrophysiological and behavioral responses of Tamarixia radiata (Hymenoptera: 
Eulophidae) to volatiles of nymphal Diaphorina citri (Hemiptera: Liviidae).

Liu YM(1), Huang YY(1)(2), Wang FF(1)(2), Hu YW(3), Zhang ZL(4), Cuthbertson 
AGS(5), Qiu BL(2), Sang W(1)(2).

Author information:
(1)Engineering Research Center of Biological Control, Ministry of 
Education/College of Plant Protection, South China Agricultural University, 
Guangzhou 510642, China.
(2)Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
(3)National Modern Agricultural Industry Science and Technology Innovation 
Center of Guangzhou, Guangzhou 510520, China.
(4)Hubei Key Laboratory of Quality Control of Characteristic Fruits and 
Vegetables, College of Life Science and Technology, Hubei Engineering 
University, Xiaogan 432000, China.
(5)Independent Science Advisor, York YO10 5AQ, UK.

Huanglongbing (HLB), a devastating citrus disease caused by Candidatus 
Liberibacter asiaticus, is efficiently vectored by the Asian citrus psyllid, 
Diaphorina citri Kuwayama (Hemiptera: Liviidae). Tamarixia radiata (Waterston) 
plays a crucial role as an ectoparasitoid, preying on D. citri nymphs. By 
collecting and identifying headspace volatiles from fifth instar nymphs of D. 
citri using a gas chromatograph-mass spectrometer (GC-MS), we obtained a 
collection of 9 volatile compounds. These compounds were subsequently chosen to 
investigate the electrophysiological and behavioral responses of female T. 
radiata. At a concentration of 10 μg/μl, 9 compounds were compared with 
cis-3-hexen-1-ol (control), resulting in trans-2-nonenal inducing the highest 
relative electroantennogram (EAG) value, followed by hexanal, heptanal, 
n-heptadecane, tetradecanal, n-tetradecane, n-pentadecane, 1-tetradecanol, and 
1-dodecanol. The top 5 EAG responses of female T. radiata to these compounds 
were further investigated through EAG dose-response experiments. The results 
showed positive dose-responses as concentrations increased from 0.01 to 10 
μg/μl. In Y-tube olfactometer bioassays, female T. radiata exhibited a 
preference for specific compounds. They were significantly attracted to 
tetradecanal at a concentration of 10 µg/µl and trans-2-nonenal at 0.01 µg/µl, 
while no significant attraction was observed toward hexanal, heptanal, or 
n-heptadecane. Our report is the first to demonstrate that volatiles produced by 
D. citri nymphs attract T. radiata, which suggests that this parasitoid may 
utilize nymph volatiles to locate its host.

© The Author(s) 2024. Published by Oxford University Press on behalf of 
Entomological Society of America.

DOI: 10.1093/jisesa/ieae060
PMCID: PMC11135360
PMID: 38809687 [Indexed for MEDLINE]