Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. Front Chem. 2022 Oct 5;10:1022533. doi: 10.3389/fchem.2022.1022533. eCollection 2022. Studies toward synthesis of the core skeleton of spiroaspertrione A. Shen ZH(1), Lu SY(1), Zheng JY(1), Zhang XZ(1), Peng JB(1), Ma AJ(1). Author information: (1)School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China. Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1'-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed. Copyright © 2022 Shen, Lu, Zheng, Zhang, Peng and Ma. DOI: 10.3389/fchem.2022.1022533 PMCID: PMC9581311 PMID: 36277342 Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 2. J Org Chem. 2017 Mar 17;82(6):3125-3131. doi: 10.1021/acs.joc.7b00056. Epub 2017 Feb 24. Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp. TJ23. He Y(1), Hu Z(1), Sun W(1), Li Q(1), Li XN(2), Zhu H(1), Huang J(1), Liu J(1), Wang J(1), Xue Y(1), Zhang Y(1). Author information: (1)Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China. (2)State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, China. Bioassay-guided isolation of cultures of Aspergillus sp. TJ23 yielded a novel terpene-polyketide hybrid spiromeroterpenoid, spiroaspertrione A (1), bearing a unique spiro[bicyclo[3.2.2]nonane-2,1'-cyclohexane] carbocyclic skeleton, and a new biointermediate, andiconin B (2). Their structures and absolute configurations were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compound 1 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold from 32 to 1 μg/mL. DOI: 10.1021/acs.joc.7b00056 PMID: 28219242 [Indexed for MEDLINE]