Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. Nat Prod Res. 2023 Apr;37(8):1321-1327. doi: 10.1080/14786419.2021.2005591. Epub 2021 Dec 22. Cytisine-like alkaloids from the seeds of Ormosia hosiei Hemsl. et Wils. Zhang L(1), Zheng L(2), Wang Q(1), Pana Z(1), Zhang X(3), Huang M(3), Xu H(1), Ni L(1)(4). Author information: (1)College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, People's Republic of China. (2)Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China. (3)College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, People's Republic of China. (4)Fujian Colleges and University Engineering Research Institute of Conservation & Utilization of Natural Bioresources, Fujian Agriculture and Forestry University, Fuzhou, People's Republic of China. Two new cytisine-like alkaloids, hositisines C (1) and D (2), were isolated from the seeds of Ormosia hosiei along with four known compounds, (-)-tinctorine (3), β-adenosine (4), 2'-deoxyadenosine (5), and 7, 2', 4'-trihydroxy-5-methoxyisoflavanone (6). Their structures were established using extensive spectroscopic techniques (UV, IR, CD, HRESIMS, 1 D and 2 D NMR). In the cytotoxic activity, compounds 1-3 and 5-fluorouracil (positive control) displayed inhibitory effects against HepG2 cells, exhibiting IC50 values of 44.52 ± 7.83 μM, 111.49 ± 12.76 μM, 127.72 ± 18.67 μM, and 16.37 ± 3.82 μM. DOI: 10.1080/14786419.2021.2005591 PMID: 34933632 [Indexed for MEDLINE] 2. Phytochemistry. 2002 Dec;61(8):975-8. doi: 10.1016/s0031-9422(02)00394-1. Quinolizidine alkaloids from the curare adjuvant Clathrotropis glaucophylla. Sagen AL(1), Gertsch J, Becker R, Heilmann J, Sticher O. Author information: (1)Department of Applied BioSciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Winterthurerstr 190, CH-8057, Zurich, Switzerland. The bark of Clathrotropis glaucophylla (Fabaceae) is used as admixture of curare arrow poison by the Yanomami; Amerindians in Venezuela. A new quinolizidine alkaloid (QA), (-)-13alpha-hydroxy-15alpha-(1-hydroxyethyl)-anagyrine [(-)-clathrotropine], was isolated from the alkaloid extract of C. glaucophylla bark, together with eleven known QAs: (-)-anagyrine, (-)-thermopsine, (-)-baptifoline, (-)-epibaptifoline, (-)-rhombifoline, (-)-tinctorine, (-)-cytisine, (-)-N-methylcytisine, (-)-lupanine, (-)-6alpha-hydroxylupanine and (+)-5,6-dehydrolupanine. The isolation and structure elucidation were performed with the aid of chromatographic (TLC, HPLC and CC) and spectroscopic (UV and 1D/2D NMR) methods, and mass spectrometry. To our knowledge, this is the first time quinolizidine alkaloids have been isolated from an arrow poison ingredient. It is also the first report on Clathrotropis species being used for preparation of arrow poison. DOI: 10.1016/s0031-9422(02)00394-1 PMID: 12453529 [Indexed for MEDLINE]