Psychoactive Plant Database - Neuroactive Phytochemical Collection

1. Inorg Chem. 2024 Nov 6. doi: 10.1021/acs.inorgchem.4c04247. Online ahead of 
print.

From β-KB(3)O(4)F(2) to α-KB(3)O(4)F(2): Phase Transition-Directed Great Changes 
in Structure and Optical Anisotropy.

Niu R(1)(2), Liu Q(1)(2), Gai M(1)(2), Yang Z(1)(2), Han S(1)(2), Pan S(1)(2).

Author information:
(1)Research Center for Crystal Materials, State Key Laboratory of Functional 
Materials and Devices for Special Environmental Conditions; Xinjiang Key 
Laboratory of Functional Crystal Materials, Xinjiang Technical Institute of 
Physics & Chemistry, CAS, 40-1 South Beijing Road, Urumqi 830011, China.
(2)Center of Materials Science and Optoelectronics Engineering, University of 
Chinese Academy of Sciences, Beijing 100049, China.

Herein, a new fluorooxoborate α-KB3O4F2 is synthesized successfully in a closed 
system. It crystallizes in the P21/n space group and features the rare 
one-dimensional (1D) zigzag [B6O8F4]∞ chains built by fundamental building 
blocks (FBBs) [B6O9F4]. To the best of our knowledge, KB3O4F2 is a unique 
example of inorganic anhydrous borate whose two polymorphs show 1D B-O/F chains 
constructed by different FBBs but the same symmetry operation. Different from 
β-KB3O4F2, the inconsistent arrangement of π-conjugated [B2O5] units in 
α-KB3O4F2 makes it exhibit a small birefringence (0.011@546 nm). Further, 
α-KB3O4F2 owns a deep-ultraviolet (DUV) cutoff edge (<200 nm), suggesting that 
it has a potential application as the zero-order waveplate material in the DUV 
region.

DOI: 10.1021/acs.inorgchem.4c04247
PMID: 39503510


2. Biomed Res Int. 2024 Aug 20;2024:6623114. doi: 10.1155/2024/6623114.
eCollection  2024.

Unveiling the Therapeutic Potential of Systemic Ozone on Skin Wound Repair: 
Clinical, Histological, and Immunohistochemical Study in Rats.

de Medeiros Cardoso J(1), Ervolino E(2), Miyasawa EM(1), Theodoro LH(3), Padovan 
LEM(1), Pereira EL(2), de Molon RS(3), Garcia VG(1).

Author information:
(1)Department of Implantology Latin American Institute of Dental Research and 
Teaching (ILAPEO), Curitiba, PR, Brazil.
(2)Department of Basic Sciences School of Dentistry São Paulo State University 
(UNESP), Araçatuba, São Paulo, Brazil.
(3)Department of Diagnostic and Surgery School of Dentistry São Paulo State 
University (UNESP), Araçatuba, São Paulo, Brazil.

This study sought to examine the effects of systemic ozone (O3) treatment on the 
healing of skin wounds induced on the dorsal surface of Wistar rats. The skin 
wounds were created using a 10 mm round punch following the sagittal medial 
plane in 72 rats. Then, the animals were randomly assigned to four groups, each 
receiving the following treatments: group C, which did not undergo treatment 
with the O3/O2 mixture; group OZ0.3, administered the O3/O2 mixture at a dose of 
0.3 mg/kg; group OZ0.7, given the O3/O2 mixture at a dose of 0.7 mg/kg; and 
group OZ1.0, provided with the O3/O2 mixture at a dose of 1.0 mg/kg. Six animals 
from each group were euthanized at 7, 14, and 21 days postoperatively. Clinical, 
histological, histometric, and immunohistochemical (IHC) analyses were 
accomplished. Data from clinical and histometric assessments revealed that OZ0.7 
and OZ1.0 demonstrated more favorable healing, with greater wound contraction 
observed in the OZ1.0 group at 14 and 21 days. Histologically, the OZ1.0 group 
exhibited aspects consistent with an accelerated tissue repair process. IHC 
analysis revealed greater vascular endothelial growth factor (VEGF) 
immunostaining in the OZ0.7 (7 days) and OZ1.0 (7 and 14 days) groups compared 
to the C group. Expression of transforming growth factor beta-1 was 
significantly increased in the OZ0.7 (14 days) and OZ1.0 (7 and 14 days) groups 
compared to the C group. In conclusion, our data suggest that systemic use of O3 
enhanced tissue repair in cutaneous wounds in a dose-dependent manner, with 
concentrations of 1.0 mg/kg providing the most beneficial effects. Furthermore, 
the results of this study implicate the use of O3 for the treatment of skin 
wounds aiming at improving the healing process over time. Our findings suggest 
the use of O3 as a viable alternative to enhance wound healing and repair.

Copyright © 2024 Jânderson de Medeiros Cardoso et al.

DOI: 10.1155/2024/6623114
PMCID: PMC11535271
PMID: 39502273 [Indexed for MEDLINE]

Conflict of interest statement: The authors declare no conflicts of interest.


3. J Phys Chem B. 2024 Nov 5. doi: 10.1021/acs.jpcb.4c02776. Online ahead of
print.

Formation of β-U(3)O(8) from UCl(3) Salt Compositions under Oxygen Exposure.

Tuffy BW(1), Birkner NR(2), Schorne-Pinto J(3), Davis RC(4), Mofrad AM(3), Dixon 
CM(3), Aziziha M(3), Christian MS(3), Lynch TJ(1), Bartlett MT(1), Besmann 
TM(3), Brinkman KS(2), Chiu WKS(1).

Author information:
(1)School of Mechanical, Aerospace and Manufacturing Engineering, University of 
Connecticut, Storrs, Connecticut 06369-3139, United States.
(2)Department of Materials Science and Engineering, Clemson University, Clemson, 
South Carolina 29634-0901, United States.
(3)Nuclear Engineering Program, University of South Carolina, Columbia, South 
Carolina 29208, United States.
(4)Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator 
Laboratory, Menlo Park, California 94025, United States.

Complementary X-ray absorption fine structure (XAFS) and Raman spectroscopy 
studies were conducted on various UCl3 concentrations in alkali chloride salt 
compositions. The samples were 5 mol % UCl3 in LiCl (S1), 5 mol % UCl3 in KCl 
(S2), 5 mol % UCl3 in LiCl-KCl eutectic (S4), 50 mol % UCl3 in KCl (S5), and 20 
mol % UCl3 in KCl (S6) molar concentrations. Samples were heated to 800 °C and 
allowed to cool to room temperature with measurements performed at selected 
temperatures; the highest temperatures showed the most stability and will be 
primarily referenced for conclusions. The processing and interpretation of the 
Raman and extended X-ray absorption fine structure (EXAFS) peaks revealed 
several uranium-oxygen bond lengths and symmetries in the samples before, 
during, and after heating. Based on published thermodynamic data of similar 
systems, X-ray absorption fine structure spectroscopy, and identification of 
Raman peaks, a β variation of α-U3O8, typical at room temperature, is the 
suspected dominant phase of all samples at high temperatures (800 °C). In the 
existing literature, this β structure of U3O8 was synthesized by slow cooling of 
uranium oxides from 1350 °C. This paper suggests the rapid formation of the 
compound due to the decomposition of the uranium chlorides or oxychlorides at 
increasing temperatures and O2 reaction kinetics.

DOI: 10.1021/acs.jpcb.4c02776
PMID: 39500582


4. J Chromatogr A. 2024 Oct 28;1738:465477. doi: 10.1016/j.chroma.2024.465477. 
Online ahead of print.

Optimizing ultrasonication-assisted comprehensive extraction of bioactive 
flavonoids from Pterocarpus santalinus leaves using response surface 
methodology.

Dahat Y(1), Ganguly S(2), Khan A(2), Gajbhiye RL(3), Kumar D(4).

Author information:
(1)Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical 
Biology (IICB), 4, Raja SC Mullick Road, Jadavpur, Kolkata-700032, India; 
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, India.
(2)Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical 
Biology (IICB), 4, Raja SC Mullick Road, Jadavpur, Kolkata-700032, India.
(3)National Institute of Pharmaceutical Education and Research (NIPER), Export 
Promotion Industrial Park (EPIP), Zandaha Road, NH322, Hajipur, 844102, India.
(4)Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical 
Biology (IICB), 4, Raja SC Mullick Road, Jadavpur, Kolkata-700032, India; 
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, India. 
Electronic address: deepak@iicb.res.in.

The leaves of Pterocarpus santalinus have been identified as a good source of 
health-beneficial flavonoids through the amalgamation of untargeted metabolomics 
using UHPLC-ESI-MSn leading to the identification of flavone-glycosides bearing 
isorhamnetin and quercetin skeletons. To unveil the optimum ultrasonication 
extraction conditions required for the comprehensive extraction of major 
flavone-glycosides, 
isorhamnetin-3-O-β-d-(2-O-α-L-rhamnopyranosyl)glucopyranoside and 
isorhamnetin-3-O-β-d-glucopyranoside, the response surface methodology based on 
Box-Behnken design was adopted. The influence of input extraction parameters 
extraction time (X1): 15-45 min, temperature (X2): 40-60 °C and biomass-solvent 
ratio (X3): 60-100 on the extractive yield and comprehensive flavonoid content 
resulted in the optimal conditions as 19.09 min, 48.65 oC, and 72.15, 
respectively. The investigation provides a sustainable approach for recovering 
health-beneficial flavone-glycosides for utilization in various industries.

Copyright © 2024 Elsevier B.V. All rights reserved.

DOI: 10.1016/j.chroma.2024.465477
PMID: 39500076

Conflict of interest statement: Declaration of competing interest The authors 
declare that they have no known competing financial interests or personal 
relationships that could have appeared to influence the work reported in this 
paper.


5. AMB Express. 2024 Nov 4;14(1):118. doi: 10.1186/s13568-024-01776-3.

Crotalaria madurensis flavonol glycosides' antibacterial activity against 
Staphylococcus aureus.

Mohammed HS(1), Abu El Wafa SA(1), Ibrahim MH(2), Fathy RM(3), Seif-Eldein 
NA(4).

Author information:
(1)Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy, Al-Azhar 
University, Cairo, Egypt.
(2)Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of 
Pharmacy (Girls), Al-Azhar University, Cairo, 11884, Egypt.
(3)Drug Radiation Research Department, National Center for Radiation Research 
and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.
(4)Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy, Al-Azhar 
University, Cairo, Egypt. nohaseifeldein@azhar.edu.eg.

Methicillin-resistant Staphylococcus aureus (MRSA) infections are prevalent in 
hospitals and often lead to significant health complications. This study aimed 
to explore the chemical composition of the aerial part of Crotalaria madurensis 
and evaluate its antioxidant and antibacterial properties. The impact of gamma 
irradiation on the antibacterial properties of the plant extract and metabolite 
1 against MRSA was also examined. Fourier-transform infrared (FTIR) analysis was 
conducted on the filtrates of untreated MRSA and MRSA treated with the plant 
extract and metabolite 1. Four flavonol glycosides were identified as gossypetin 
8-methoxy, 3-O-β-D-xylopyranoside (metabolite 1), gossypetin 
8-O-β-D-glucopyranoside (metabolite 2), kaempferol 3-O-β-D-glucpyranoside 
(Astragalin, metabolite 3), and herbacetin 7-methoxy-3-O-β-D-glucopyranoside 
(metabolite 4). All metabolites exhibited significant antioxidant properties 
using different assays. The antibacterial efficacy of the extract and metabolite 
1, which showed substantial antioxidant properties compared to the other 
isolated metabolites, was evaluated. Both the plant extract and metabolite 1 
significantly reduced the viability and cell count of MRSA at concentrations of 
1.0 and 0.5 mg/ml. The antibacterial activity of the plant extract and 
metabolite 1 was assessed after gamma irradiation at 50 and 100 Gy, which did 
not significantly affect the antibacterial efficiency. FTIR analysis indicated 
that the plant extract and metabolite 1 significantly altered the band frequency 
values, bandwidth, and peak intensity % of the treated MRSA filtrate. Molecular 
docking studies suggested that metabolite 1 exhibited the highest antioxidant 
and anti-MRSA activity, with strong binding scores like the ligand, indicating 
an effective interaction and high affinity between metabolite 1 and the target 
molecule.

© 2024. The Author(s).

DOI: 10.1186/s13568-024-01776-3
PMCID: PMC11535145
PMID: 39495369

Conflict of interest statement: The authors declare no competing interests.