Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. Org Lett. 2020 Oct 2;22(19):7609-7612. doi: 10.1021/acs.orglett.0c02811. Epub 2020 Sep 14. Enantioselective Total Synthesis of Mollebenzylanol A. Kawamoto Y(1), Karube F(1), Kobayashi T(1), Ito H(1). Author information: (1)School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. Mollebenzylanol A is a tyrosine phosphatase 1B inhibitor isolated from the leaves of Rhododendron molle in 2018 that has a highly functionalized structure. The first enantioselective total synthesis of mollebenzylanol A was achieved in 13 steps from a known chiral starting material. An efficient and practical synthetic scheme was disclosed in a stereocontrolled manner, including stereo/regioselective epoxidation, Eschenmoser-Claisen rearrangement, and stereocontrolled dihydroxylation. DOI: 10.1021/acs.orglett.0c02811 PMID: 32924500 2. Nat Prod Rep. 2018 Jun 20;35(6):496-500. doi: 10.1039/c8np90015a. Hot off the Press. Hill RA(1), Sutherland A. Author information: (1)School of Chemistry, Glasgow University, Glasgow, G12 8QQ, UK. Bob.Hill@glasgow.ac.uk Andrew.Sutherland@glasgow.ac.uk. A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as mollebenzylanol A from Rhododendron molle. DOI: 10.1039/c8np90015a PMID: 29878011 [Indexed for MEDLINE]