Psychoactive Plant Database - Neuroactive Phytochemical Collection

1. Chemosphere. 2024 Sep;363:142885. doi: 10.1016/j.chemosphere.2024.142885. Epub
 2024 Jul 16.

Indeno[1,2,3-cd]pyrene enhances the sensitivity of airway epithelial cells to 
ferroptosis and aggravates asthma.

Yu H(1), Zhang C(2), Pan H(3), Gao X(4), Wang X(1), Xiao W(1), Yan S(3), Gao 
Y(1), Fu J(5), Zhou Y(6).

Author information:
(1)Department of Critical Care Medicine, Children's Hospital of Fudan 
University, National Children's Medical Center, and the Shanghai Key Laboratory 
of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and 
Metabolism, Ministry of Science and Technology, Institutes of Biomedical 
Sciences, Fudan University, Shanghai, 200032, China; National Health Commission 
(NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China.
(2)Department of Critical Care Medicine, Children's Hospital of Fudan 
University, National Children's Medical Center, and the Shanghai Key Laboratory 
of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and 
Metabolism, Ministry of Science and Technology, Institutes of Biomedical 
Sciences, Fudan University, Shanghai, 200032, China.
(3)Department of Otorhinolaryngology, Shenzhen Children's Hospital, Shenzhen, 
Guangdong, China.
(4)Department of Experimental Surgery, Tangdu Hospital, The Fourth Military 
Medical University, Xi'an, Shaanxi, China.
(5)Department of General Medicine, Children's Hospital of Fudan University, 
Shanghai, China. Electronic address: fujinrong@fudan.edu.cn.
(6)Department of Critical Care Medicine, Children's Hospital of Fudan 
University, National Children's Medical Center, and the Shanghai Key Laboratory 
of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and 
Metabolism, Ministry of Science and Technology, Institutes of Biomedical 
Sciences, Fudan University, Shanghai, 200032, China; National Health Commission 
(NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China. 
Electronic address: yfzhou1@fudan.edu.cn.

Particulate matter of aerodynamic diameter ≤2.5 μm (PM2.5) exposure induces 
oxidative stress in lung tissues. Ferroptosis is a form of regulated cell death 
based on oxidative damage and lipid peroxidation. Whether PM2.5 exposure-induced 
oxidative stress can promote ferroptosis to aggravate asthma is not known. To 
investigate if PM2.5 exposure induces oxidative stress to promote ferroptosis 
and influence asthma development, a cockroach extract-induced asthma model in 
mice was used for in vivo studies. Airway epithelial cell (AEC) ferroptosis was 
detected by assays (CCK8, malonaldehyde, and 4-hydroxynonenal). Molecular 
mechanisms were investigated by real-time reverse transcription-quantitative 
polymerase chain reaction, western blotting, flow cytometry, liquid 
chromatography-tandem mass spectrometry, and chromatin immunoprecipitation. We 
found that exposure to PM2.5 and Indeno[1,2,3-cd] pyrene (IP; one of the 
prominent absorbed polycyclic aromatic hydrocarbons in PM2.5) enhanced the 
sensitivity of AECs to ferroptosis to aggravate asthma, whereas ferroptosis 
inhibitors and cytosolic phospholipase A2 (cPLA2) inhibitors reversed this 
augmented inflammatory response in mice suffering from asthma. IP treatment 
enhanced cPLA2 expression/activation through aryl hydrocarbon receptor (AhR) 
genomic and non-genomic pathways, resulting in arachidonic-acid release to 
promote the sensitivity of AECs to ferroptosis. IP exposure enhanced the release 
of leukotriene-B4 from lung macrophages, resulting in enhanced expression of 
acyl-coA synthetase long chain family member4 (ACSL4) and the sensitivity of 
AECs to ferroptosis. This finding suggests that exposure to PM2.5 and IP promote 
ferroptosis sensitivity in AECs to aggravate asthma, which may provide new 
targets for the prevention and treatment of asthma.

Copyright © 2024 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.chemosphere.2024.142885
PMID: 39025314 [Indexed for MEDLINE]

Conflict of interest statement: Declaration of Competing interest No conflict of 
interest exits in the submission of this manuscript, and manuscript is approved 
by all authors for publication. I would like to declare on behalf of my 
co-authors that the work described was original research that has not been 
published previously, and not under consideration for publication elsewhere, in 
whole or in part.


2. Luminescence. 2024 Jan;39(1):e4610. doi: 10.1002/bio.4610. Epub 2023 Oct 25.

A single 8-hydroxyquinoline-appended bile acid fluorescent probe obtained by 
click chemistry for solvent-dependent and distinguishable sensing of zinc(II) 
and cadmium(II).

Zhang Z(1), Zou Y(1), Liu J(2).

Author information:
(1)Institute of Molecular Science and Application, Engineering Research Center 
of Energy Storage Materials and Devices, Ministry of Education, School of 
Chemistry, Xi'an Jiaotong University, Xi'an, China.
(2)Xi'an Modern Chemistry Research Institute, Xi'an, China.

Construction of fluorescent probes for zinc ion (Zn2+ ) and cadmium ion (Cd2+ ) 
is significant for the safety of humans. However, the discriminating recognition 
of Zn2+ and Cd2+ by a single probe remains challenging owing to their similar 
properties. Herein, a novel deoxycholic acid derivative containing 
8-hydroxyquinoline fluorophore has been facilely synthesized through click 
chemistry to form a clamp-like probe. Using its perfect bonding cavity from 
1,2,3-triazole and quinoline, this molecule showed favorable solvent-dependent 
fluorescent responses and distinguished Zn2+ and Cd2+ in different solvents. In 
ethanol aqueous solution, it displayed good selectivity and ratiometric 
fluorescence to Zn2+ with 30 nm spectroscopic red-shifts. In acetonitrile 
aqueous solution, it exhibited good selectivity and ratiometric fluorescence to 
Cd2+ with 18 nm spectroscopic red-shifts. Moreover, the unique microstructural 
features of the probe in assembly were used to reflect its recognition 
processes. Due to its merits of low detection limit and instant response time, 
the probe was utilized for sensing Zn2+ and Cd2+ in water, beer and urine with 
high accuracy. Meanwhile, this probe served as a handy tool and was employed to 
obtain inexpensive test strips for the prompt and semiqualitative analysis of 
Zn2+ and Cd2+ with the naked eye.

© 2023 John Wiley & Sons Ltd.

DOI: 10.1002/bio.4610
PMID: 37880919 [Indexed for MEDLINE]


3. Org Lett. 2014 Oct 3;16(19):5088-91. doi: 10.1021/ol502437y. Epub 2014 Sep 15.

Conversion of 2-furylcarbinols with alkyl or aryl azides to highly 
functionalized 1,2,3-triazoles via cascade formal [3 + 2] 
cycloaddition/ring-opening.

Guo J(1), Yu B, Wang YN, Duan D, Ren LL, Gao Z, Gou J.

Author information:
(1)Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of 
Education, School of Chemistry & Chemical Engineering, and ‡School of Chemistry 
and Materials Science, Shaanxi Normal University , Xi'an 710062, China.

A Lewis acid promoted cascade cycloaddition/ring-opening of 2-furylcarbinols 
with alkyl or aryl azides is described. The reaction features an initial formal 
[3 + 2] cycloaddition to form a trisubstitued triazole motif, followed by a ring 
opening of furan to generate the (E)-configuration of the enone. A wide range of 
highly functionalized triazoles is expediently and efficiently synthesized in a 
highly step-economical manner.

DOI: 10.1021/ol502437y
PMID: 25222823 [Indexed for MEDLINE]


4. Mol Neurobiol. 2014 Feb;49(1):234-50. doi: 10.1007/s12035-013-8515-6. Epub
2013  Aug 10.

The proform of glia cell line-derived neurotrophic factor: a potentially 
biologically active protein.

Sun XL(1), Chen BY, Duan L, Xia Y, Luo ZJ, Wang JJ, Rao ZR, Chen LW.

Author information:
(1)Institute of Neurosciences, Fourth Military Medical University, Xi'an, 
710032, People's Republic of China.

Growing evidences have revealed that the proforms of several neurotrophins 
including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), 
and neurotrophin-3 (NT3), by binding to p75 neurotrophin receptor and sortilin, 
could induce neuronal apoptosis and are implicated in the pathogenesis of 
various neurodegenerative diseases. The glial cell line-derived neurotrophic 
factor (GDNF), one of the most potent useful neurotrophic factors for the 
treatment of Parkinson's disease (PD), is firstly synthesized as the proform 
(proGDNF) like other neurotrophin NGF, BDNF, and NT3. However, little is known 
about proGDNF expression and secretion under physiological as well as 
pathological states in vivo or in vitro. In this study, we investigated the 
expression profile and dynamic changes of proGDNF in brains of aging and PD 
animal models, with the interesting finding that proGDNF was a predominant form 
of GDNF with molecular weight of about 36 kDa by reducing and nonreducing 
immunoblots in adult brains and was unregulated in the aging, lipopolysaccharide 
(LPS), and 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) insult. We 
further provided direct evidence that accompanied activation of primary 
astrocytes as well as C6 cell line induced by LPS stimulation, proGDNF was 
increasingly synthesized and released as the uncleaved form in cell culture. 
Taken together, our results strongly suggest that proGDNF may be a biologically 
active protein and has specific effects on the cells close to its secreting 
site, and a potentially important role of proGDNF signaling in the brains, in 
the glia-neuronal interaction or in the pathogenesis of PD, should merit further 
investigation.

DOI: 10.1007/s12035-013-8515-6
PMID: 23934644 [Indexed for MEDLINE]


5. Guang Pu Xue Yu Guang Pu Fen Xi. 2013 May;33(5):1194-7.

[Characterization of the different organic matter from soils and sediments].

[Article in Chinese]

Gao B(1), Zhou HD, Jin J, Sun K.

Author information:
(1)Department of Water Environment, China Institute of Water Resources and 
Hydropower Research, Beijing 100038, China. gaobo@iwhr.com

The humic acid (HA) and nonhydrolyzable carbons (NHC) were isolated from three 
river sediment samples (1, 2, 3) from the rivers in the Tongzhou district of 
Beijing and four soil samples(4, 5, 6, and 7) from the surface soils in the 
vicinity area of Tianjin near Bohai Bay, respectively. The isolated HA and NHC 
fractions were also characterized using elementary analysis, X-ray photoelectron 
spectroscopy (XPS), solid state 13C cross-polarization and magic angle spinning 
nuclear magnetic resonance spectroscopy (13C NMR), and Fourier transformed 
infrared spectroscopy (FTIR). The results showed that NHC had lower H/ C and O/C 
atomic ratios than HA from the same source. The sum of surface O-containing 
groups accounted for 7.6%-10.7% and 40.9%-46.7% in NHC and HA samples, 
respectively. 13C NMR and FTIR spectra of the NHC samples revealed a large 
contribution of alkyl carbon and aryl carbon. In addition, the NHCs isolated 
from soils had higher content of aromatic carbon than the NHC form river 
sediments. Systematic characterization showed that the NHC samples were more 
condensed and hydrophobicity than the HA samples.

PMID: 23905317