Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. Fitoterapia. 2019 Nov;139:104369. doi: 10.1016/j.fitote.2019.104369. Epub 2019 Oct 15. Bioactive polyketides from the mangrove endophytic fungi Phoma sp. SYSU-SK-7. Chen Y(1), Yang W(2), Zou G(2), Chen S(2), Pang J(2), She Z(3). Author information: (1)School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China; School of Marin Sciences, Sun Yat-sen University, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. (2)School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China. (3)School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China; School of Marin Sciences, Sun Yat-sen University, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. Electronic address: cesshzhg@mail.sysu.edu.cn. Five new polyketides, colletotric B (2), 3-hydroxy-5-methoxy-2,4,6-trimethylbenzoic acid (3), colletotric C (4), chaetochromone D (6) and 8-hydroxy-pregaliellalactone B (9), together with four known analogues (1, 5 and 7-8) were isolated from the mangrove endophytic fungus Phoma sp. SYSU-SK-7. Their structures were elucidated by analysis of extensive spectroscopic data and mass spectrometric data. Compounds 1-2 showed strong antimicrobial activity against the P. aeruginosa, MRSA and C. albicans with the MIC values in the range of 1.67-6.28 μg/ml. Furthermore, Compounds 1-5 also exhibited significant α-glucosidase inhibitory activity with the IC50 values in the range of 36.2-90.6 μM. Compound 7 was found to inhibited radical scavenging activity against DPPH with the EC50 value of 11.8 μM. Copyright © 2019. Published by Elsevier B.V. DOI: 10.1016/j.fitote.2019.104369 PMID: 31626911 [Indexed for MEDLINE]