Psychoactive Plant Database - Neuroactive Phytochemical Collection

1. ACS Sens. 2024 Nov 6. doi: 10.1021/acssensors.4c02109. Online ahead of print.

Highly Sensitive and Biocompatible Microsensor for Selective Dynamic Monitoring 
of Dopamine in Rat Brain.

Chen J(1), Xia F(1), Ding X(1), Zhang D(1).

Author information:
(1)School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 
710061, People's Republic of China.

Highly selective and sensitive in vivo neurotransmitter dynamic monitoring of 
the central nervous system has long been a challenging endeavor. Here, an 
implantable and biocompatible microsensor with excellent performances was 
reported by electrodepositing poly(3,4-ethylenedioxythiophene)-electrochemically 
reduced graphene oxide (PEDOT-ERGO) nanocomposites and poly(tannic acid) (pTA) 
sequentially on the carbon fiber electrode (CFE) surface, and its feasibility in 
in vivo electrochemical sensing applications were demonstrated. Due to the 
synergistic electrocatalytic effect of PEDOT-ERGO nanocomposites with the 
negative-charged pTA on dopamine (DA) redox reaction, the microsensor exhibits 
high detection sensitivities of 1.1 and 0.37 nA μM-1 in the detection ranges of 
0.02-0.5 and 0.5-20 μM with a low limit of detection of 9.2 nM. Also, the 
microsensor shows excellent selectivity, good sensing stability, repeatability, 
and reproducibility. In addition, the highly hydrophilic and negative-charged 
pTA inhibits the nonspecific adsorption of hydrophobic proteins, which endows 
the microsensor with good antifouling ability. Moreover, DA dynamics in rat 
brain were successfully monitored in real time, and the selective sensing 
ability of the microsensor in vivo was also demonstrated. The present study 
provides a new method for selective dynamics monitoring of DA in the brain, 
which would help to better understand the pathological and physiological 
functions of DA.

DOI: 10.1021/acssensors.4c02109
PMID: 39505410


2. ACS Appl Mater Interfaces. 2024 Nov 6. doi: 10.1021/acsami.4c15188. Online
ahead  of print.

Healable, Recyclable, and Ultra-Tough Waterborne Polyurethane Elastomer Achieved 
through High-Density Hydrogen Bonding Cross-Linking Strategy.

Wu CQ(1), Chen J(1), Long QY(1), Sun DX(1), Qi XD(1), Yang JH(1), Wang Y(1).

Author information:
(1)School of Chemistry, Key Laboratory of Advanced Technologies of Materials 
(Ministry of Education), Southwest Jiaotong University, Chengdu 610031, China.

With the increasing popularity of elastomers in industry and daily life, their 
high performance and functionality have attracted widespread attention. However, 
it is a great challenge for them to possess both high mechanical properties and 
excellent healing and recovery capabilities due to the limitations of the 
preparation methods and the intrinsic microstructure of the elastomers. In this 
study, a strategy of ice-controlled interfacial stepwise cross-linking was 
proposed to prepare the waterborne polyurethane-based elastomers with 
ultrahigh-density hydrogen bonding interaction achieved by enhancing the 
utilization rate of phenol hydroxyl groups of tannic acid to the maximum extent. 
The elastomers have incredible mechanical properties, including ultrahigh 
toughness of 1.03 GJ m-3 (which represents the highest level among polyurethane 
elastomers prepared through common processing techniques to date), extremely 
high true fracture stress of ∼1.9 GPa, world-record fracture energy of 520 kJ 
m-2, and exciting multiple functional characteristics, such as highly efficient 
self-healing ability of 10 min, high resistance to physical damage and chemical 
corrosion, broad temperature and frequency damping effects, good shape memory 
effect, and excellent melt-processing recyclability and solvent recyclability. 
These robust multifunctional elastomers represent considerable potential in 
various fields, from defense and military industry and civil transportation to 
precision manufacturing, etc.

DOI: 10.1021/acsami.4c15188
PMID: 39504516


3. Langmuir. 2024 Nov 6. doi: 10.1021/acs.langmuir.4c03548. Online ahead of
print.

Improved Emulsifying Performance of Agarose Microgels by Cross-Interfacial 
Diffusion of Polyphenols.

Jiang W(1), Xiong X(1), Zhang H(1), Li F(1), Yuan D(1), Gao Z(1), Lu W(1), Li 
Y(1), Wu Y(1).

Author information:
(1)Cooperative Innovation Center of Industrial Fermentation (Ministry of 
Education & Hubei Province), Glyn O. Phillips Hydrocolloid Research Centre, 
School of Life and Health Sciences, Hubei University of Technology, Nanli Road, 
Wuhan 430068, P. R. China.

Noninterface-active polysaccharides can acquire better emulsifying properties 
through microgelation, yet optimizing their emulsifying performance remains a 
significant challenge. This study introduces a novel approach to enhance the 
emulsifying performance of polysaccharide microgels by leveraging the 
cross-interfacial diffusion of polyphenols, which promotes the interfacial 
adsorption of microgels. Tannic acid (TA) was predispersed in oil phases and 
subsequently emulsified with agarose microgel (AM) suspensions, and the impacts 
of TA diffusion on the emulsifying performance of AMs was investigated. In 
addition, the transmittance profiles of oil-water biphasic systems were found to 
innovatively indicate the cross-interfacial diffusion of TA and the interfacial 
adsorption of AMs. The current results suggest that an appropriate level of TA 
incorporation can benefit the emulsifying performance of AMs, correlating with 
decreased droplet sizes and improved physical stability of the emulsion. 
However, excessive TA might trigger the clustering of AMs before they reach the 
interfacial layer, adversely affecting the emulsion stability. In conclusion, 
the cross-interfacial diffusion of polyphenols offers a promising strategy to 
overcome the stability challenges encountered in polysaccharide 
microgel-stabilized emulsions.

DOI: 10.1021/acs.langmuir.4c03548
PMID: 39504512


4. ACS Appl Bio Mater. 2024 Nov 6. doi: 10.1021/acsabm.4c01044. Online ahead of 
print.

A Polyphenol Decorated Triplex Hybrid Biomaterial: Structure-Function, Release 
Profiles, Sorption, and Antipathogenic Effects.

Mir M(1), Wilson LD(1).

Author information:
(1)Department of Chemistry, University of Saskatchewan, 110 Science Place, 
Thorvaldson Building, Saskatoon, Saskatchewan S7N 5C9, Canada.

Herein, nonwoven alkali modified flax substrates were coated with incremental 
levels of chitosan, followed by immobilization of tannic acid, via a facile 
"dip-coating" strategy to yield a unique hierarchal "triplex" hybrid 
biomaterial, denoted as "THB". The characterization of the physicochemical 
properties of THB employed complementary spectroscopic (IR, Raman, and NMR) 
techniques, which support the role of hydrogen bonding and electrostatic 
interactions between the components: chitosan as the secondary biopolymer 
coating and the tertiary adsorbed polyphenols. XRD and SEM techniques provide 
further structural insight that confirms the unique semicrystalline nature and 
porous hierarchal structure of the biocomposite. The THBs present a polyphenol 
kinetic release profile that follows the Korsmeyer-Peppas model that concurs 
with Fickian diffusion for heterogeneous polymer systems. Furthermore, these 
systems demonstrate a tailored solvent uptake capacity (up to 4 g/g) in aqueous 
PBS media. Antipathogenic activity tests revealed 95% elimination of pathogens 
(E. coli, S. aureus, and C. albicans) at a dose of 50 mg for the THB system. The 
trend in the structure-property relationships for the THB systems indicates 
synergistic effects of electrostatic multiform interactions between protonated 
chitosan and the polyphenol units. Herein, we report the first example of a 
unique hierarchal biomaterial via a facile design strategy for diversiform roles 
as responsive adsorbents for environmental remediation to biomedical 
applications (e.g., controlled release, topical administration, or antimicrobial 
surface coatings).

DOI: 10.1021/acsabm.4c01044
PMID: 39504466


5. ACS Appl Mater Interfaces. 2024 Nov 6. doi: 10.1021/acsami.4c09955. Online
ahead  of print.

Enhancing Strawberry Freshness: Multifunction Sustainable Films Utilizing Two 
Types of Modified Carbon Nanotubes for Photothermal Food Packaging.

Chen X(1), Wang L(1)(2), Zhang D(1), Bu N(3), Liu W(2), Wu Z(1), Mu R(1), Tan 
P(1), Zhong Y(1), Pang J(1).

Author information:
(1)College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
350002, China.
(2)Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, 
Shandong University, Jinan 250100, China.
(3)State Key Laboratory of Chemical Resource Engineering, Beijing Advanced 
Innovation Center for Soft Matter Science and Engineering, Beijing University of 
Chemical Technology, Beijing 100029, China.

Currently, antimicrobial films with stable and efficient antibacterial 
activities are receiving considerable attention in the food packaging industry. 
Herein, a chemically/physically linked konjac glucomannan-sodium alginate 
(KGM-SA)@carbon nanotubes (CNTs)/Fe3+ composite film with outstanding resistance 
to ultraviolet radiation, oxidation, and bacteria, as well as excellent 
photothermal effects and mechanical properties, was successfully prepared using 
a solvent flow method. Tannic acid-modified carboxyl-functionalized CNTs 
(TCCNTs), l-cysteine-modified carboxyl-functionalized CNTs (LCCNTs), and Fe3+ 
were incorporated into the prepared film. The film structure of KGM-SA@CNTs/Fe3+ 
was characterized using various methods, confirming the formation of a 
dual-cross-linked network through metal-coordination bonds and hydrogen bonding. 
This unique structure endowed the film with excellent water vapor permeability 
(3.58 g mm/m2 day kPa), water resistance (water contact angle = 93.66°), and 
thermal stability. Further, the film exhibited outstanding photothermal 
conversion efficiency and stability under near-infrared irradiation (300 mW/cm2) 
as well as excellent bactericidal properties against Staphylococcus aureus and 
Escherichia coli, achieving a bacterial inhibition rate of >99%. In a strawberry 
preservation experiment, the KGM-SA@CNTs/Fe3+ composite film exhibited 
remarkable preservation effects, extending the shelf life of strawberries by 4-6 
d. Thus, this photothermal antibacterial film offers a new approach for the 
application of CNTs in food packaging.

DOI: 10.1021/acsami.4c09955
PMID: 39504039