Psychoactive Plant Database - Neuroactive Phytochemical Collection

1. Dalton Trans. 2023 Aug 22;52(33):11451-11457. doi: 10.1039/d3dt01718d.

Ligand-dependent structural diversity and optimizable CO(2) chemical fixation 
activities of Cu-doped polyoxo-titanium clusters.

Lin X(1)(2), Yu YH(1)(2), Chen GH(1), Li QH(1), Zhang L(1), Zhang J(1).

Author information:
(1)State Key Laboratory of Structural Chemistry, Fujian Institute of Research on 
the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. 
R. China. lqh2382@fjirsm.ac.cn.
(2)University of Chinese Academy of Sciences, Beijing 100049, P. R. China.

Heterometallic oxo clusters have been attracting intensive interest due to their 
unique properties originating from the synergistic interactions between 
different components. Herein, we report the construction and catalytic 
applications of a family of copper-doped polyoxo-titanium clusters (Cu-PTCs) 
coordinated with different acetate derivative ligands. The solvothermal 
reactions of metal salts and trimethylacetic acid or 1,2-phenylenediacetic acid 
in ethanol produced Ti6Cu3(μ3-O)4(μ2-O)(OEt)16(L1)4 (L1 = trimethyl acetate, 
PTC-367) and H2Ti8Cu2Br2(μ4-O)2(μ2-O)4(OEt)20(L2)2 (L2 = 1,2-phenylenediacetate, 
PTC-368), respectively. When smaller acetic acid was introduced as a stabilizing 
ligand, higher nuclei H2Ti16Cu3(μ4-O)5(μ3-O)15(μ2-O)3(OiPr)18(Ac)8 (Ac = 
acetate, PTC-369) and H3Ti29Cu3(μ4-O)6(μ3-O)30(μ2-O)8(OiPr)17(Ac)20 (PTC-370) 
were prepared. The number of metal ions exposed on the surface of the four 
clusters changes due to variations in the steric hindrance of functionalizing 
ligands, and theoretically, so does their catalytic activity as Lewis acids. In 
light of this, we conducted a carbon dioxide cycloaddition reaction in an 
atmospheric environment and the four obtained compounds displayed increasing 
catalytic activities from PTC-367 to PTC-370. These results provide a feasible 
synthetic method for modulating the structures of Cu-doped titanium oxide 
materials and improving their catalytic activities.

DOI: 10.1039/d3dt01718d
PMID: 37547997


2. Eur Spine J. 2023 Apr;32(4):1411-1420. doi: 10.1007/s00586-023-07597-5. Epub 
2023 Feb 23.

Residual motion of different posterior instrumentation and interbody fusion 
constructs.

Burkhard MD(1), Spirig JM(2), Wanivenhaus F(2), Cornaz F(2), Fasser MR(3)(4), 
Widmer J(3)(4), Farshad M(2).

Author information:
(1)Department of Orthopedic Surgery, Balgrist University Hospital, University of 
Zurich, Forchstrasse 340, 8008, Zurich, Switzerland. marco.burkhard@balgrist.ch.
(2)Department of Orthopedic Surgery, Balgrist University Hospital, University of 
Zurich, Forchstrasse 340, 8008, Zurich, Switzerland.
(3)Institute for Biomechanics, Balgrist Campus, ETH Zurich, Lengghalde 5, 
CH-8008, Zurich, Switzerland.
(4)Spine Biomechanics, Department of Orthopedic Surgery, Balgrist University 
Hospital, University of Zurich, Zurich, Switzerland.

PURPOSE: To elucidate residual motion of cortical screw (CS) and pedicle screw 
(PS) constructs with unilateral posterior lumbar interbody fusion (ul-PLIF), 
bilateral PLIF (bl-PLIF), facet-sparing transforaminal lumbar interbody fusion 
(fs-TLIF), and facet-resecting TLIF (fr-TLIF).
METHODS: A total of 35 human cadaver lumbar segments were instrumented with PS 
(n = 18) and CS (n = 17). Range of motion (ROM) and relative ROM changes were 
recorded in flexion/extension (FE), lateral bending (LB), axial rotation (AR), 
lateral shear (LS), anterior shear (AS), and axial compression (AC) in five 
instrumentational states: without interbody fusion (wo-IF), ul-PLIF, bl-PLIF, 
fs-TLIF, and fr-TLIF.
RESULTS: Whereas FE, LB, AR, and AC noticeably differed between the 
instrumentational states, AS and LS were less prominently affected. Compared to 
wo-IF, ul-PLIF caused a significant increase in ROM with PS (FE + 42%, LB + 24%, 
AR + 34%, and AC + 77%), however, such changes were non-significant with CS. ROM 
was similar between wo-IF and all other interbody fusion techniques. Insertion 
of a second PLIF (bl-PLIF) significantly decreased ROM with CS (FE -17%, LB 
-26%, AR -20%, AC -51%) and PS (FE - 23%, LB - 14%, AR - 20%, AC - 45%,). Facet 
removal in TLIF significantly increased ROM with CS (FE + 6%, LB + 9%, AR + 17%, 
AC of + 23%) and PS (FE + 7%, AR + 12%, AC + 13%).
CONCLUSION: bl-PLIF and TLIF show similarly low residual motion in both PS and 
CS constructs, but ul-PLIF results in increased motion. The fs-TLIF technique is 
able to further decrease motion compared to fr-TLIF in both the CS and PS 
constructs.

© 2023. The Author(s).

DOI: 10.1007/s00586-023-07597-5
PMID: 36820922 [Indexed for MEDLINE]


3. Span J Psychiatry Ment Health. 2024 Apr-Jun;17(2):71-80. doi: 
10.1016/j.rpsm.2021.08.003. Epub 2021 Sep 4.

Humanization in mental health plans in Spain.

Fraguas D(1), Zarco J(2), Balanzá-Martínez V(3), Blázquez García JF(4), Borràs 
Murcia C(5), Cabrera A(6), Carretero J(7), Crespo A(8), Díaz-Marsá M(9), Gasul 
V(10), González MA(11), Grande I(12), Muela C(13), de Las Heras Liñero E(14), 
Mayoral F(15), Morales Cano G(16), Pagés-Lluyot JR(17), Romo J(18), Serrano 
Marín B(19), Sauceda AL(20), Arango C(18).

Author information:
(1)Instituto de Psiquiatría y Salud Mental, Hospital Clínico San Carlos, IdISSC, 
CIBERSAM, Facultad de Medicina, Universidad Complutense, Madrid, Spain. 
Electronic address: davidfraguas@gmail.com.
(2)Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense, 
Madrid, Spain.
(3)Departamento de Medicina, Universitat de València, CIBERSAM, Valencia, Spain.
(4)Coordinación de RSC, Hospital Clínico San Carlos, Madrid, Spain.
(5)Presidenta fundadora de «Después del Suicidio-Asociación de Supervivientes» 
(DSAS).
(6)Asociación Madrileña de Amigos y Familiares de Personas con Esquizofrenia 
(AMAFE).
(7)Recursos Humanos, Gestor y Desarrollo de Profesionales de Enfermería, 
Hospital Universitario Infanta Leonor, Madrid, Spain.
(8)Centro de Salud Mental Puente de Vallecas, Hospital Universitario Infanta 
Leonor-Hospital Virgen de la Torre, Colegio Oficial de Trabajo Social de Madrid, 
Madrid, Spain.
(9)Instituto de Psiquiatría y Salud Mental, Hospital Clínico San Carlos, IdISSC, 
CIBERSAM, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
(10)Centro de Salud Torrent 2, Coordinador Grupo de Salud Mental SEMERGEN, 
Valencia, Spain.
(11)Departamento de Neurociencias, Universidad del País Vasco, Servicio de 
Psiquiatría, Hospital Universitario de Basurto, Bilbao, Vizcaya, Spain.
(12)Unidad de Trastornos Bipolares y Depresivos, Instituto de Nerociencias, 
Hospital Clínic, Universidad de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
(13)Asociación Nuevo Horizonte, Federación Autismo Madrid, Madrid, Spain.
(14)Servicio de Psiquiatría, Complejo Hospitalario Universitario de Vigo, 
SERGAS, Grupo de Neurociencias Traslacional, Instituto de Investigación 
Sanitaria Galicia Sur, CIBERSAM, Vigo, Pontevedra, Spain.
(15)Hospital Regional Universitario de Málaga, IBIMA, Málaga, Spain.
(16)Fundación Mundo Bipolar, Madrid, Spain.
(17)Fundación Asistencia Nacional de Ayuda a Enfermos de Depresión (ANAED).
(18)Servicio del Niño y el Adolescente, Instituto de Psiquiatría y Salud Mental, 
Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Facultad de 
Medicina, Universidad Complutense, Madrid, Spain.
(19)Fundación ASAM Familia y Asociación Salud y Ayuda Mutua (ASAM).
(20)FEAFES Salud Mental Extremadura.

INTRODUCTION: Mental health (MH) care has important challenges, especially in 
the field of humanization. Our objectives were to identify the humanization 
measures in MH plans of the Spanish autonomous communities (AC) and the 
priorities to be developed in this area.
MATERIAL AND METHODS: A large and multidisciplinary group of people involved in 
MH care participated in a consensus, according to a modified Delphi method, 
based on «design thinking», in three phases: (1) identification of humanization 
measures in MH plans of AC; (2) analysis of the implementation of these 
measures; and (3) identification of humanization priorities in MH.
RESULTS: Fourteen of the 17 AC have current MH plans. They contained four types 
of humanization measures: (1) improvement of the quality of care; (2) promotion 
of user participation; (3) campaigns against stigma and discrimination; (4) 
caring for especially vulnerable people. Implementation of measures ranged from 
6.3% (i.e.: specific budget) to 100%, with an average of 64.1%. We identified 
priority issues, operationalized in 5 proposals: (1) information campaigns; (2) 
multidisciplinary meeting forums; (3) platforms of support entities; (4) 
strategies on MH education; (5) humanization in study plans.
CONCLUSIONS: Some MH plans include humanization among their objectives, but 
partially. The implementation of humanization proposals such as those identified 
in this study is essential to achieve a high-quality MH care.

Copyright © 2021 Sociedad Española de Psiquiatría y Salud Mental (SEPSM). 
Published by Elsevier España S.L.U. All rights reserved.

DOI: 10.1016/j.rpsm.2021.08.003
PMID: 34492375 [Indexed for MEDLINE]


4. Front Genet. 2020 Nov 30;11:591794. doi: 10.3389/fgene.2020.591794.
eCollection  2020.

Frameshift Variant in Novel Adenosine-A1-Receptor Homolog Associated With Bovine 
Spastic Syndrome/Late-Onset Bovine Spastic Paresis in Holstein Sires.

Krull F(1), Hirschfeld M(1), Wemheuer WE(1), Brenig B(1).

Author information:
(1)Department of Animal Sciences, Faculty of Agricultural Sciences, Institute of 
Veterinary Medicine, University of Göttingen, Göttingen, Germany.

Since their first description almost 100 years ago, bovine spastic paresis (BSP) 
and bovine spastic syndrome (BSS) are assumed to be inherited 
neuronal-progressive diseases in cattle. Affected animals are characterized by 
(frequent) spasms primarily located in the hind limbs, accompanied by severe 
pain symptoms and reduced vigor, thus initiating premature slaughter or 
euthanasia. Due to the late onset of BSP and BSS and the massively decreased 
lifespan of modern cattle, the importance of these diseases is underestimated. 
In the present study, BSP/BSS-affected German Holstein breeding sires from 
artificial insemination centers were collected and pedigree analysis, 
genome-wide association studies, whole genome resequencing, protein-protein 
interaction network analysis, and protein-homology modeling were performed to 
elucidate the genetic background. The analysis of 46 affected and 213 control 
cattle revealed four significantly associated positions on chromosome 15 
(BTA15), i.e., AC_000172.1:g.83465449A>G (-log10P = 19.17), 
AC_000172.1:g.81871849C>T (-log10P = 8.31), AC_000172.1:g.81872621A>T (-log10P = 
6.81), and AC_000172.1:g.81872661G>C (-log10P = 6.42). Two additional loci were 
significantly associated located on BTA8 and BTA19, i.e., 
AC_000165.1:g.71177788T>C and AC_000176.1:g.30140977T>G, respectively. Whole 
genome resequencing of five affected individuals and six unaffected relatives 
(two fathers, two mothers, a half sibling, and a full sibling) belonging to 
three different not directly related families was performed. After filtering, a 
homozygous loss of function variant was identified in the affected cattle, 
causing a frameshift in the so far unknown gene locus LOC100848076 encoding an 
adenosine-A1-receptor homolog. An allele frequency of the variant of 0.74 was 
determined in 3,093 samples of the 1000 Bull Genomes Project.

Copyright © 2020 Krull, Hirschfeld, Wemheuer and Brenig.

DOI: 10.3389/fgene.2020.591794
PMCID: PMC7734149
PMID: 33329738

Conflict of interest statement: The authors declare that the research was 
conducted in the absence of any commercial or financial relationships that could 
be construed as a potential conflict of interest.


5. Int J Health Econ Manag. 2019 Dec;19(3-4):371-394. doi: 
10.1007/s10754-019-09260-3. Epub 2019 Jan 22.

Attitudes to reform: Could a cooperative health insurance scheme work in Russia?

Kaneva M(1)(2), Gerry CJ(3), Avxentiev N(4)(5), Baidin V(6).

Author information:
(1)International Laboratory for Healthcare Economics and Its Reforms, Gaidar 
Institute for Economic Policy, Gazetny Pereulok 3-5, Building 1, Office 471, 
Moscow, Russia, 125993. kaneva@iep.ru.
(2)Institute of Economics and Industrial Engineering, Siberian Branch of the 
Russian Academy of Sciences, 17 Ac. Lavrentieva Prospekt, office 373, 
Novosibirsk, Russia, 630090. kaneva@iep.ru.
(3)Oxford School of Global and Area Studies (OSGA), University of Oxford, 12 
Bevington Road, Oxford, OX2 6LH, UK.
(4)Institute for Social Analysis and Forecasting of The Russian Presidential 
Academy of National Economy and Public Administration (ISAF RANEPA), 
Prechistenskaya Naberezhnaya 11, Moscow, Russia, 119034.
(5)Center for Perspective Financial Planning, Macroeconomic Analysis and 
Financial Statistics, Financial Research Institute of Ministry of Finance, 
Nastasyinsky Pereulok 3, Building 2, Office 110, Moscow, Russia, 127006.
(6)Center for Fiscal Policy, Financial Research Institute of Ministry of 
Finance, Nastasyinsky Pereulok 3, Building 2, Office 101, Moscow, Russia, 
127006.

As for all health systems, in Russia, the demand for medical care is greater 
than its health system is able to guarantee the supply of. In this context, 
removing services from the state guaranteed package is an option that is 
receiving serious consideration. In this paper, we examine the attitudes of the 
Russian population to such a reform. Exploiting a widely-used methodology, we 
explore the population's willingness to pay for cooperative health insurance. 
Distinguishing between socioeconomic and demographic factors, health-related 
indicators and risk aversion we find, consistent with other literature, positive 
income and risk aversion effects. We interpret the former as evidence that the 
Russian population is not opposed to the idea of progressive redistribution, to 
pool the costs of health-related risks; and the latter as evidence that 
risk-averse individuals demand more insurance coverage. In exploring these 
results further, we show that cognitive bias is important: overestimating the 
benefits leads to the purchase of additional insurance, while underestimating 
lowers demand for insurance. Our overall conclusion is that the introduction of 
a supplementary cooperative health insurance scheme in Russia could increase the 
accessibility of healthcare, lower the tendency for informal payments, 
incentivize the personal maintenance of good health and create a new source of 
funding for public healthcare.

DOI: 10.1007/s10754-019-09260-3
PMID: 30671697 [Indexed for MEDLINE]