Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. Bioorg Med Chem. 2005 Oct 1;13(19):5635-9. doi: 10.1016/j.bmc.2005.05.054. New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human kappa opioid receptors. Lee DY(1), Ma Z, Liu-Chen LY, Wang Y, Chen Y, Carlezon WA Jr, Cohen B. Author information: (1)Bio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. Bioactivity-guided fractionation of the leaves of Salvia divinorum has resulted in the isolation of three new neoclerodane diterpenoids: divinatorin D (1), divinatorin E (2), and salvinorin G (3), together with 10 known terpenoids, divinatorin C (4), hardwickiic acid (5), salvinorin-A (6), -B (7), -C (8), -D (9), -E (10), and -F (11), presqualene alcohol (12), and (E)-phytol (13). The structures of these three new compounds were characterized by spectroscopic methods. All these compounds were evaluated for their binding affinities to the human kappa opioid receptors. In comparison with divinatorin D (1), divinatorin E (2), and salvinorin G (3), salvinorin A (6) is still the most potent kappa agonist. DOI: 10.1016/j.bmc.2005.05.054 PMID: 16084728 [Indexed for MEDLINE] 2. J Biol Chem. 1971 Oct 25;246(20):6254-71. Presqualene alcohol. Further evidence on the structure of a C 30 precursor of squalene. Edmond J, Popják G, Wong SM, Williams VP. PMID: 4399596 [Indexed for MEDLINE] 3. J Am Chem Soc. 1971 Apr 7;93(7):1785-6. doi: 10.1021/ja00736a039. Stereoselective total synthesis of (plus or minus)-presqualene alcohol. Coates RM, Robinson WH. DOI: 10.1021/ja00736a039 PMID: 5550252 [Indexed for MEDLINE] 4. J Am Chem Soc. 1971 Apr 7;93(7):1782-3. doi: 10.1021/ja00736a037. Synthesis and conversion of presqualene alcohol to squalene. Altman LJ, Kowerski RC, Rilling HC. DOI: 10.1021/ja00736a037 PMID: 5550251 [Indexed for MEDLINE]