Psychoactive Plant Database - Neuroactive Phytochemical Collection

1. Int J Mol Sci. 2024 May 27;25(11):5838. doi: 10.3390/ijms25115838.

Antidepressant-like Effects of Chinese Quince (Chaenomeles sinensis) Fruit Based 
on In Vivo and Molecular Docking Studies.

Lim DW(1), Yoo G(1), Kim YT(1), Lee C(1).

Author information:
(1)Division of Functional Food Research, Korea Food Research Institute, Wanju 
55365, Republic of Korea.

In this study, we examined the potential antidepressant-like effects of Chinese 
quince fruit extract (Chaenomeles sinensis fruit extract, CSFE) in an in vivo 
model induced by repeated injection of corticosterone (CORT)-induced depression. 
HPLC analysis determined that chlorogenic acid (CGA), neo-chlorogenic acid 
(neo-CGA), and rutin (RT) compounds were major constituents in CSFE. Male ICR 
mice (5 weeks old) were orally administered various doses (30, 100, and 300 
mg/kg) of CSFE and selegiline (10 mg/kg), a monoamine oxidase B (MAO-B) 
inhibitor, as a positive control following daily intraperitoneal injections of 
CORT (40 mg/kg) for 21 days. In our results, mice treated with CSFE exhibited 
significant improvements in depressive-like behaviors induced by CORT. This was 
evidenced by reduced immobility times in the tail suspension test and forced 
swim test, as well as increased step-through latency times in the passive 
avoidance test. Indeed, mice treated with CSFE also exhibited a significant 
decrease in anxiety-like behaviors as measured by the elevated plus maze test. 
Moreover, molecular docking analysis indicated that CGA and neo-CGA from CSFE 
had stronger binding to the active site of MAO-B. Our results indicate that CSFE 
has potential antidepressant effects in a mouse model of repeated injections of 
CORT-induced depression.

DOI: 10.3390/ijms25115838
PMCID: PMC11172133
PMID: 38892026 [Indexed for MEDLINE]

Conflict of interest statement: The authors declare no conflicts of interest.


2. Foods. 2023 Mar 9;12(6):1158. doi: 10.3390/foods12061158.

Hydrogen Sulfide Enhances Browning Repression and Quality Maintenance in 
Fresh-Cut Peaches via Modulating Phenolic and Amino Acids Metabolisms.

Wang L(1), Zhang C(1), Shi K(1), Chen S(1), Shao J(1), Huang X(1), Wang M(1), 
Wang Y(1), Song Q(1).

Author information:
(1)Anhui Agricultural Products Processing Engineering Laboratory, Key Laboratory 
of Agricultural Product Fine Processing and Resource Utilization, Ministry of 
Agriculture and Rural Affairs, College of Tea and Food Science and Technology, 
Anhui Agricultural University, Hefei 210036, China.

Effects of hydrogen sulfide (H2S) on the browning and quality maintenance of 
fresh-cut peach fruit were studied. The results showed that H2S treatment 
repressed the development of surface browning, suppressed the increase in 
respiration rate and weight loss, and delayed the decline of firmness while 
soluble solids content (SSC) and microbial growth were unaffected during 
storage. H2S treatment maintained higher contents of phenolic compounds, 
especially neo-chlorogenic acid, catechin, and quercetin, and delayed the 
degradation of phenolic compounds by enhancing the activities of phenolic 
biosynthesis-related enzymes and inhibiting the oxidative activities of 
polyphenol oxidase (PPO) in comparison with control. Moreover, H2S stimulated 
the accumulation of amino acids and their derivatives including proline, 
γ-aminobutyric acid (GABA), and polyamines (PAs) via enhancing biosynthesis and 
repressing degradation compared to control. These results suggested that H2S 
treatment enhanced the accumulation of phenolic, amino acids, and their 
derivatives by modulating phenolic and amino acids metabolisms, which 
contributed to the higher antioxidant activity and membrane integrity 
maintenance, ultimately repressing browning development and maintaining the 
quality. Therefore, the current study speculated that H2S might be a promising 
approach for browning inhibition and quality maintenance in fresh-cut peach 
fruit.

DOI: 10.3390/foods12061158
PMCID: PMC10048349
PMID: 36981085

Conflict of interest statement: The authors declare no conflict of interest.


3. Phytochem Anal. 2019 Sep;30(5):556-563. doi: 10.1002/pca.2850. Epub 2019 Jul
8.

Metabolomics approach based on NMR spectroscopy and multivariate data analysis 
to explore the interaction between the leafminer Tuta absoluta and tomato 
(Solanum lycopersicum).

de Falco B(1)(2), Manzo D(1), Incerti G(3), Garonna AP(1), Ercolano M(1), 
Lanzotti V(1).

Author information:
(1)Department of Agricultural Sciences, University of Naples Federico II, 
Portici, Naples, Italy.
(2)School of Science, Engineering & Technology, Division of Food & Drink, 
University of Abertay, Dundee, Scotland, UK.
(3)Department of Agri-Food, Animal and Environmental Sciences, University of 
Udine, Udine, Italy.

INTRODUCTION: Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) is one of the 
most devastating and harmful pests of tomato (Solanum lycopersicum) crops 
causing up to 80-100% yield losses. A large arsenal of plant metabolites is 
induced by the leafminer feeding including defence compounds that could differ 
among varieties.
OBJECTIVE: To compare the metabolomic changes of different genotypes of tomato 
(tolerant "T", susceptible "S" and "F1" hybrid obtained between T and S) after 
exposition to T. absoluta.
METHODOLOGY: Nuclear magnetic resonance (NMR) spectroscopy followed by 
multivariate data analysis were performed to analyse the metabolic profiles of 
control and infested samples on three different tomato genotypes.
RESULTS: Signals related to GABA (γ-aminobutyric acid) were relatively much 
higher in all infested samples compared to the non-infested plants used as 
control. Infested T genotype samples were the most abundant in organic acids, 
including fatty acids and acyl sugars, chlorogenic acid, neo-chlorogenic acid 
and feruloyl quinic acid, indicating a clear link between the exposure to 
leafminer. Results also showed an increase of trigonelline in all tomato 
varieties after exposition to T. absoluta.
CONCLUSION: Metabolomics approach based on NMR spectroscopy followed by 
multivariate data analysis allowed for a detailed metabolite profile of plant 
defences, providing fundamental information for breeding programmes in plant 
crops.

© 2019 John Wiley & Sons, Ltd.

DOI: 10.1002/pca.2850
PMID: 31286582 [Indexed for MEDLINE]


4. Food Sci Nutr. 2016 Jul 12;5(3):380-389. doi: 10.1002/fsn3.403. eCollection
2017  May.

Hydroxycinnamic acids in cooked potato tubers from Solanum tuberosum group 
Phureja.

Piñeros-Niño C(1), Narváez-Cuenca CE(2), Kushalappa AC(3), Mosquera T(1).

Author information:
(1)Facultad de Ciencias Agrarias Universidad Nacional de Colombia Carrera 30 
No.45 - 03, Edificio 500 Bogotá Colombia.
(2)Departamento de Química Universidad Nacional de Colombia Carrera 30 No.45 - 
03, Edificio 451 Bogotá Colombia.
(3)Plant Science Department McGill University Sainte-Anne-de-Bellevue Quebec H9X 
3V9 Canada.

Hydroxycinnamic acids are phenolic compounds and are considered to have health 
promotion properties due to their antioxidant activity. Potato tubers of 113 
genotypes of Solanum tuberosum group Phureja belonging to the Colombian Central 
Collection, landraces of potatoes, and commercial cultivars were evaluated for 
their hydroxycinnamic acids content. The composition of these compounds was 
analyzed using cooked tubers in two different agro-climatic conditions. The 
genotypes were analyzed for chlorogenic acid, neo-chlorogenic acid, 
crypto-chlorogenic acid, and caffeic acid by ultrahigh-performance liquid 
chromatography (UHPLC). Chlorogenic acid was the major representative and varied 
between 0.77 to 7.98 g kg-1 DW (dry weight) followed by crypto-chlorogenic acid 
(from 0.09 to 1.50 g kg-1 DW). Under moorland agro-climatic conditions even 
though the chlorogenic acid levels increased with respect to flatland 
agro-climatic conditions, the related isomer neo-chlorogenic acid decreased as 
compared to flatland conditions. The correlation between chlorogenic acid with 
the isomers, and with caffeic acid was positive. This study demonstrated that 
there is a wide variation in hydroxycinnamic acids contents in the germplasm 
studied, which can be exploited in breeding programs to contribute to human 
health.

DOI: 10.1002/fsn3.403
PMCID: PMC5448355
PMID: 28572921


5. J Agric Food Chem. 2012 Oct 24;60(42):10501-10. doi: 10.1021/jf303398z. Epub 
2012 Oct 15.

An optimized method for analysis of phenolic compounds in buds, leaves, and 
fruits of black currant ( Ribes nigrum L.).

Vagiri M(1), Ekholm A, Andersson SC, Johansson E, Rumpunen K.

Author information:
(1)Department of Plant Breeding and Biotechnology-Balsgård, Swedish University 
of Agricultural Sciences, Fjälkestadsvägen 459, SE-291 94 Kristianstad, Sweden. 
michael.rajeev.vagiri@slu.se

Although the fruits are the economic driver for the black currant industry, the 
buds and leaves are excellent sources of beneficial phenolic compounds that may 
contribute to the future value of the crop. In this study, extraction of 
phenolic compounds for different parts of the black currant plant was optimized, 
and an efficient method for their separation by HPLC was developed. This allowed 
the simultaneous quantification of a range of hydroxycinnamic acids, 
flavan-3-ols, flavonols, and anthocyanins by DAD following their identification 
by HPLC-ESI-MS(n). A total of 23 compounds were detected in the buds, 22 of 
which were found in fruit and leaves. To the best of our knowledge, this is the 
first report of flavonol glycosides of quercetin, myricetin, isorhamnetin, and 
kaempferol along with hydroxycinnamic acids such as neo-chlorogenic acid and 
chlorogenic acid in the buds. Additionally, we provide the first evidence of 
kaempferol-3-O-rutinoside in black currant leaves. This approach offers avenues 
for superior combined compositional identification and cultivar selection 
targeted at the generation of polyphenol-rich products derived from the whole 
crop and not just the fruit.

DOI: 10.1021/jf303398z
PMID: 23046518 [Indexed for MEDLINE]