Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. J Asian Nat Prod Res. 2017 Aug;19(8):793-802. doi: 10.1080/10286020.2016.1248947. Epub 2016 Nov 16. Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. Guo TT(1), Zhang JC(2), Zhang H(3), Liu QC(1), Zhao Y(3), Hou YF(1), Bai L(1), Zhang L(1), Liu XQ(2), Liu XY(4), Zhang SY(4), Bai NS(1). Author information: (1)a Department of Pharmaceutical Engineering, College of Chemical Engineering , Northwest University , Xi'an 710069 , China. (2)b Quartermaster Research Institute of the General Logistic Department , China-Hemp Research Center , Beijing 100082 , China. (3)c Laboratory Animal Center , Fourth Military Medical University , Xi'an 710032 , China. (4)d Department of Medicinal Chemistry, School of Pharmacy , Fourth Military Medical University , Xi'an 710032 , China. In this paper, 17 compounds (1-17) were isolated from the leaves of Hemp (Cannabis sativa f. sativa). Among the isolates, two were determined to be new spirans: cannabispirketal (1), and α-cannabispiranol 4'-O-β-D-glucopyranose (2) by 1D and 2D NMR spectroscopy, LC-MS, and HRESIMS. The known compounds 7, 8, 10, 13, 15, and 16 were isolated from Hemp (C. sativa f. sativa) for the first time. Furthermore, compounds 8 and 13 were isolated from the nature for the first time. All isolated compounds were evaluated for cytotoxicity on different tissue-derived passage cancer cell lines through cell viability and apoptosis assay. Among these compounds, compounds 5, 9 and 16 exhibited a broad-spectrum antitumor effect via inhibiting cell proliferation and promoting apoptosis. These results obtained have provided valuable clues to the understanding of the cytotoxic profile for these isolated compounds from Hemp (C. sativa f. sativa). DOI: 10.1080/10286020.2016.1248947 PMID: 27848262 [Indexed for MEDLINE] 2. Phytochemistry. 2008 Oct;69(14):2627-33. doi: 10.1016/j.phytochem.2008.07.010. Epub 2008 Sep 4. Non-cannabinoid constituents from a high potency Cannabis sativa variety. Radwan MM(1), Elsohly MA, Slade D, Ahmed SA, Wilson L, El-Alfy AT, Khan IA, Ross SA. Author information: (1)National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. Six new non-cannabinoid constituents were isolated from a high potency Cannabis sativa L. variety, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), cannflavin C (5) and beta-sitosteryl-3-O-beta-d-glucopyranoside-2'-O-palmitate (6). In addition, five known compounds, alpha-cannabispiranol (7), chrysoeriol (8), 6-prenylapigenin (9), cannflavin A (10) and beta-acetyl cannabispiranol (11) were identified, with 8 and 9 being reported for the first time from cannabis. Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics. DOI: 10.1016/j.phytochem.2008.07.010 PMCID: PMC4888767 PMID: 18774146 [Indexed for MEDLINE]