Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. Zhongguo Zhong Yao Za Zhi. 2020 Oct;45(20):4929-4937. doi: 10.19540/j.cnki.cjcmm.20200523.201. [Study on chemical bibenzyls in Dendrobium gratiosissimum]. [Article in Chinese] Jia-Wei S(1), Ji-Mei L(1), Ri-Dao C(1), Yu-Yu L(1), Yan LI(1), Shan C(2), Xiao-Mei C(3), Shun-Xing G(3), Jun-Gui D(1). Author information: (1)State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Key Laboratory of Natural Drug Biosynthesis of National Health Committee,Key Laboratory of Enzymes and Natural Drug Biocatalysis of Chinese Academy of Medical Sciences,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050,China. (2)Department of Immunology,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050,China. (3)Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193,China. Nineteen compounds were isolated and structurally characterized from an ethanol extract of Dendrobium gratiossimum, including dendrogratiol A(1), DDB-1(2), 3,4-dihydroxyl-5,3',4'-trimethoxybibenzyl(3), amoenylin(4), chrysotoxine(5), DTB(6), 3,4,4'-trihydroxyl-5,3'-dimethoxybenzyl(7), 3-methylgiga(8), aloifol(9), gigantol tetramethyl ether(10), batatasin Ⅲ(11), moscatilin(12), moniliformine(13), gigantol(14), DMB(15), flavanthrinin(16), cannithrene-2(17), 3,4-dihydroxyl-5,4'-dimethoxystilbene(18) and 4-hydroxy-3,5,4'-trimethoxystilbene(19). 1 was a new compound, and 2-10, 16, 18 and 19 were obtained from this plant species for the first time. In vitro cytotoxic and antiviral activities of these isolates were evaluated, which displayed that 4 showed moderate cytotoxicity against human hepatoma cell line HepG2 with the IC_(50) of 10.15 μmol·L~(-1); 7 and 12 exhibited moderate inhibitory activity towards HIV virus with the IC_(50) of 9.35 and 9.15 μmol·L~(-1), respectively; and 10 displayed inhibitory activity against IAV virus with the IC_(50) of 8.90 μmol·L~(-1). DOI: 10.19540/j.cnki.cjcmm.20200523.201 PMID: 33350266 [Indexed for MEDLINE]