Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
1. Org Biomol Chem. 2022 Jan 19;20(3):658-666. doi: 10.1039/d1ob02258j. A unified total synthesis of benzo[d][1,3]dioxole-type benzylisoquinoline alkaloids of aporphines, coptisines, and dibenzopyrrocolines. Lv J(1), Li ZH(1), Deng AJ(1), Qin HL(1). Author information: (1)State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. qinhailin@imm.ac.cn. The first total synthesis of (S)-(+)-ovigerine, (S)-(+)-N-formylovigerine, and (6aS,6a'S)-(+)-ovigeridimerine of aporphine alkaloids with a benzo[d][1,3]dioxole structure feature was established. The strategy was based upon the well-known Pd-catalyzed arylation to set the aporphine framework, and Noyori asymmetric hydrogenation followed by diastereoselective resolution to achieve excellent enantioselectivity. By slightly modifying the total synthetic route and strategically combining it with a aza-Michael addition, Bischler-Napieralski reaction and N-arylation, this methodology was also applied to the total syntheses of benzo[d][1,3]dioxole-type benzylisoquinoline alkaloids of coptisines and dibenzopyrrocolines, including two impatiens, tetrahydrocoptisine, and quaternary coptisine bromide of coptisines and two dibenzopyrrocoline analogues, with the syntheses of all of these target compounds being efficient. Among the nine synthesized compounds, the total syntheses of the three aporphines and the two impatiens, all with ee values of greater than 99%, were reported for the first time. This work also represents the first unification of synthetic routes for the total synthesis of benzo[d][1,3]dioxole-type aporphines, coptisines, and dibenzopyrrocolines. DOI: 10.1039/d1ob02258j PMID: 34951439 2. Planta Med. 1996 Dec;62(6):528-33. doi: 10.1055/s-2006-957963. New dimeric aporphine alkaloids and cytotoxic constituents of Hernandia nymphaeifolia. Chen JJ(1), Ishikawa T, Duh CY, Tsai IL, Chen IS. Author information: (1)Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China. Three minor new dimeric aporphine alkaloids, oviisocorydine (1), ovihernangerine (2), and oxohernandaline (3), along with four known alkaloids, (+)-hernandaline, (+)-thallcarpine, (+)-N-methylovigerine, and N-methylcorydaldine, and five known lignans, (+)-epimagnolin, (+)-epiaschantin, (+)-epiyangambin, (-)-deoxypodophyllotoxin, and (-)-yatein, have been additionally isolated from the trunk bark of Hernandia nymphaeifolia. The structures of these compounds were elucidated by spectroscopic methods. Among forty-four isolates obtained till now, nine compounds, hernandonine (4), hernanymphine (5), demethylsonodione (6), (+)-ovigerine (7), (+)-N-methylovigerine (8), N-formyldehydroovigerine (9), 4-methoxyoxohernandaline (10), (-)-deoxypodophyllotoxin (11), and (-)-yatein (12) showed significant cytotoxic activities (ED50 values < 1 microgram/ml) against P-388, KB16, A549, and HT-29 cell lines. DOI: 10.1055/s-2006-957963 PMID: 9000885 [Indexed for MEDLINE] 3. Planta Med. 1995 Dec;61(6):537-9. doi: 10.1055/s-2006-959366. New p-quinonoid aporphine alkaloids and antiplatelet aggregation constituents of Hernandia sonora. Chen IS(1), Chen JJ, Tsai IL, Chang YL, Teng CM. Author information: (1)Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China. Three minor new p-quinonoid aporphine alkaloids, sonodione (1), demethylsonodione (2), and norsonodione (3), have been additionally isolated from the stem bark of Hernandia sonora. The structures of these compounds were elucidated by spectral analysis. Among the isolates obtained till now, five compounds, ovigerine (4), hernangerine (5), N-methylhernangerine (6), (+)-malekulatine (7), and isovanillin (8) showed moderate antiplatelet aggregation activity in vitro. DOI: 10.1055/s-2006-959366 PMID: 8824949 [Indexed for MEDLINE]