"



  Psychoactive Plant Database - Neuroactive Phytochemical Collection





Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.

 

Compound Summary

 

PLANT NAME:- Scletium tortuosum (L.) N.E.Br.     PPD ID:- PPD-ID7_2


COMPOUND/COMMON NAME:- channaine
CAS ID
N/A
INCHI KEY
FOAPBJMMOXYHAN-UHFFFAOYSA-N
MOLECULAR WEIGHT
546.66
MOLECULAR FORMULA
C32H38N2O6
MOLECULAR MASS
546.664
BIOLOGICAL SOURCE
Scletium tortuosum (L.) N.E.Br.
DATA SOURCE
Olatunji, T. L., Siebert, F., Adetunji, A. E., Harvey, B. H., Gericke, J., Hamman, J. H., & Van der Kooy, F. (2021). Sceletium tortuosum: A review on its phytochemistry, pharmacokinetics, biological and clinical activities. Journal of ethnopharmacology, 280, 114476. https://doi.org/10.1016/j.jep.2021.114476; Veale, C. G. L., Chen, W., Chaudhary, S., Kituyi, S. N., Isaacs, M., Hoppe, H., … Viljoen, A. (2018). NMR structural elucidation of channaine, an unusual alkaloid from Sceletium tortuosum. Phytochemistry Letters, 23, 189–193. doi:10.1016/j.phytol.2017.11.018 ; Patnala, S., & Kanfer, I. (2017). Sceletium Plant Species: Alkaloidal Components, Chemistry and Ethnopharmacology. In V. Georgiev, & A. Pavlov (Eds.), Alkaloids - Alternatives in Synthesis, Modification and Application. IntechOpen. https://doi.org/10.5772/66482; Carpenter, J. M., Jourdan, M. K., Fountain, E. M., Ali, Z., Abe, N., Khan, I. A., & Sufka, K. J. (2016). The effects of Sceletium tortuosum (L.) N.E. Br. extract fraction in the chick anxiety-depression model. Journal of Ethnopharmacology, 193, 329–332. doi:10.1016/j.jep.2016.08.019 ; Dictionary of Natural Product. http://dnp.chemnetbase.com. .
CHEMICAL CLASS OF COMPOUND
Diarylheptanoids
NLRP3 DOCKING SCORE(Kcal/mol)
-4.536
CANONICAL SMILES   COc1ccc(C23C=C4C5CC6(O)CC7N(CCC57c5ccc(OC)c(OC)c5)C4(CC2NCC3)O6)cc1OC
BIOACTIVITY REPORTED FOR NEURODEGENERATIVE DISEASES   No
SYNONYMS
Channaine, 1355-47-1, 7,15-bis(3,4-dimethoxyphenyl)-19-oxa-4,18-diazahexacyclo[10.6.1.01,9.03,7.010,15.014,18]nonadec-8-en-12-ol, CHEBI:181851, AKOS040735956, NCGC00347505-02!
Back