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Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
Compound Summary
PLANT NAME:- Arnebia nobilis PPD ID:-
PPD-ID2_5
COMPOUND/COMMON NAME:- 2-(1,4-dihydroxy-4-methylpentyl)-5,8-dihydroxy-1,4-naphthoquinone; (s)-form, 1'-(3-methyl-2-butenoyl)
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CAS ID |
36883-11-1 |
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INCHI KEY |
XZDWDACMRHBQDH-UHFFFAOYSA-N |
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MOLECULAR WEIGHT |
388.42 |
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MOLECULAR FORMULA |
C21H2O7 |
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MOLECULAR MASS |
366.240 |
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BIOLOGICAL SOURCE |
Arnebia nobilis |
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DATA SOURCE |
Dictionary of Natural Product. http://dnp.chemnetbase.com. .; Gaddipati JP, Mani H, Shefali, Raj K, Mathad VT, Bhaduri AP, Maheshwari RK. Inhibition of growth and regulation of IGFs and VEGF in human prostate cancer cell lines by shikonin analogue 93/637 (SA). Anticancer Res. 2000 Jul-Aug;20(4):2547-52. PMID: 10953325; Gupta SK, Mathur IS. The effect of Arnebia nobilis and its naphthaquinones in rat Walker carcinosarcoma 256. Indian J Cancer. 1972 Mar;9(1):50-5. PMID: 5044709 ; Fazal H, Ahmad N, Haider Abbasi B. Identification, characterization, and palynology of high-valued medicinal plants. ScientificWorldJournal. 2013 Jun 10;2013:283484. doi: 10.1155/2013/283484. PMID: 23844389; PMCID: PMC3691918 ; Thangapazham RL, Singh AK, Seth P, Misra N, Mathad VT, Raj K, Maheshwari RK. Shikonin analogue (SA) 93/637 induces apoptosis by activation of caspase-3 in U937 cells. Front Biosci. 2008 Jan 1;13:561-8. doi: 10.2741/2701. PMID: 17981569 ; Mani H, Sidhu GS, Singh AK, Gaddipati J, Banaudha KK, Raj K, Maheshwari RK. Enhancement of wound healing by shikonin analogue 93/637 in normal and impaired healing. Skin Pharmacol Physiol. 2004 Jan-Feb;17(1):49-56. doi: 10.1159/000074063. PMID: 14755128; Pandeti S, Arha D, Mishra A, Reddy SS, Srivastava AK, Narender T, Tamrakar AK. Glucose uptake stimulatory potential and antidiabetic activity of the Arnebin-1 from Arnabia nobelis. Eur J Pharmacol. 2016 Oct 15;789:449-457. doi: 10.1016/j.ejphar.2016.08.010. Epub 2016 Aug 9. PMID: 27521155. | ||
CHEMICAL CLASS OF COMPOUND |
Naphthalenes |
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NLRP3 DOCKING SCORE(Kcal/mol) |
-6.948 |
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CANONICAL SMILES [C]C([C])=[C]C(=O)O[C]([C][C]C([C])([C])[O])C1=[C]C(=O)c2c([O])ccc([O])c2C1=O
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BIOACTIVITY REPORTED FOR NEURODEGENERATIVE DISEASES
No
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SYNONYMS |
36883-11-1, ARNEBIN-2, NSC291847, [1-(5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-hydroxy-4-methylpentyl] 3-methylbut-2-enoate, DTXSID30315078, NSC-291847 |
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