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Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.
Compound Summary
PLANT NAME:- Illigera luzonensis PPD ID:-
PPD-ID6_3
COMPOUND/COMMON NAME:- 1,2-dihydroxyaporphine; (s)-form, o2-me, n-de-me, n-butanoyl
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CAS ID |
N/A |
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INCHI KEY |
WAUASOMBVUHOLC-UHFFFAOYSA-N |
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MOLECULAR WEIGHT |
337.42 |
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MOLECULAR FORMULA |
C21H23NO3 |
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MOLECULAR MASS |
337.419 |
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BIOLOGICAL SOURCE |
Illigera luzonensis |
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DATA SOURCE |
Huang CH, Chan YY, Kuo PC, Chen YF, Chang RJ, Chen IS, Wu SJ, Wu TS. The constituents of roots and stems of Illigera luzonensis and their anti-platelet aggregation effects. Int J Mol Sci. 2014 Jul 31;15(8):13424-36. doi: 10.3390/ijms150813424. PMID: 25089876; PMCID: PMC4159803; Marti G, Eparvier V, Morleo B, Le Ven J, Apel C, Bodo B, Amand S, Dumontet V, Lozach O, Meijer L, Guéritte F, Litaudon M. Natural aristolactams and aporphine alkaloids as inhibitors of CDK1/cyclin B and DYRK1A. Molecules. 2013 Mar 6;18(3):3018-27. doi: 10.3390/molecules18033018. PMID: 23467012; PMCID: PMC6269938; https://doi.org/10.1016/j.phytochem.2010.12.015;Silva AG, Vila L, Marques P, Moreno L, Loza M, Sanz MJ, Cortes D, Castro M, Cabedo N. 1-(2'-Bromobenzyl)-6,7-dihydroxy-N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D2 Dopamine Receptors. J Nat Prod. 2020 Jan 24;83(1):127-133. doi: 10.1021/acs.jnatprod.9b00921. Epub 2020 Jan 14. PMID: 31933369 ; Dictionary of Natural Product. http://dnp.chemnetbase.com. . | ||
CHEMICAL CLASS OF COMPOUND |
Aporphines |
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NLRP3 DOCKING SCORE(Kcal/mol) |
-4.026 |
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CANONICAL SMILES CCCC(=O)N1CCc2cc(OC)c(O)c3c2C1Cc1ccccc1-3
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BIOACTIVITY REPORTED FOR NEURODEGENERATIVE DISEASES
No
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SYNONYMS |
N-Butanoyl -(+)-caaverine |
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