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  Psychoactive Plant Database - Neuroactive Phytochemical Collection





Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.

 

Compound Summary

 

PLANT NAME:- Banisteriopsis caapi     PPD ID:- PPD-ID1_13


COMPOUND/COMMON NAME:- harmane
CAS ID
N/A
INCHI KEY
N/A
MOLECULAR WEIGHT
182.23
MOLECULAR FORMULA
C12H10N2
MOLECULAR MASS
182.226
BIOLOGICAL SOURCE
Banisteriopsis caapi
DATA SOURCE
Afendi, F. M., Okada, T., Yamazaki, M., Hirai-Morita, A., Nakamura, Y., Nakamura, K., Ikeda, S., Takahashi, H., Altaf-Ul-Amin, M., Darusman, L. K., Saito, K., & Kanaya, S. (2012). KNApSAcK family databases: integrated metabolite-plant species databases for multifaceted plant research. Plant & cell physiology, 53(2), e1. https://doi.org/10.1093/pcp/pcr165; Farzin, D., & Mansouri, N. (2006). Antidepressant-like effect of harmane and other beta-carbolines in the mouse forced swim test. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 16(5), 324–328. https://doi.org/10.1016/j.euroneuro.2005.08.005 ; Santos, B. W. L., Moreira, D. C., Borges, T. K. D. S., & Caldas, E. D. (2022). Components of Banisteriopsis caapi, a Plant Used in the Preparation of the Psychoactive Ayahuasca, Induce Anti-Inflammatory Effects in Microglial Cells. Molecules (Basel, Switzerland), 27(8), 2500. https://doi.org/10.3390/molecules27082500; PUBCHEM
CHEMICAL CLASS OF COMPOUND
Harmala alkaloids
NLRP3 DOCKING SCORE(Kcal/mol)
-4.21
CANONICAL SMILES   Cc1nccc2c1[nH]c1ccccc12
BIOACTIVITY REPORTED FOR NEURODEGENERATIVE DISEASES   Yes
SYNONYMS
Harman, HARMANE, 486-84-0, 1-Methyl-9H-pyrido[3,4-b]indole, Aribine, Locuturine, Loturine, Aribin, Passiflorin, 1-Methyl-9H-beta-carboline, 1-Methylnorharman, Locuturin, 2-Methyl-beta-carboline, 3-Methyl-4-carboline, PYRIDOBINDOLE, L-METHYL-, 1-methyl-2-carboline, 1-Methyl-beta-carboline, 9H-Pyrido[3,4-b]indole, 1-methyl-, 1-Methyl-9H-pyrido(3,4-b)indole, NSC 54439, Zygofabagine, CCRIS 6419, 1-Methyl-.beta.-carboline, EINECS 207-642-2, MFCD00004957, L-methylpyridobindole, 9H-Pyrido(3,4-b)indole, 1-methyl-, BRN 0143898, CHEBI:5623, UNII-82D6J0535P, L-Methyl-Pyridobindole, HARMAN [MI], NSC-54439, 82D6J0535P, CHEMBL12014, DTXSID80197568, 1-Methyl-9H-pyrid(3,4-b)indole, 5-23-08-00261 (Beilstein Handbook Reference), NSC54439, 1-Methyl-9H-pyrido[3,4-b]indole, 9CI, Harman-13C2,15N, 1-Methyl-9H-pyrid[3,4-b]indole, methylbeta-carboline, 1-Methyl-9H-pyrido(3,4-b)indole, 9ci, SR-01000075915, Passiflorine, CN9, Harmane, free base, 1-Methyl-b-carboline, Harmane, 98%, Spectrum_001126, Tocris-1132, ST013856, 1-Methyl-I2-carboline, SpecPlus_000609, Prestwick0_000620, Prestwick1_000620, Prestwick2_000620, Prestwick3_000620, Spectrum3_000905, Spectrum4_001003, Lopac-H-7258, 1-Methyl-9H-b-carboline, Lopac0_000605, Oprea1_152883, BSPBio_000560, KBioGR_001465, KBioSS_001606, MLS001173587, DivK1c_006705, SCHEMBL141723, SPECTRUM1500866, SPBio_002779, 1-Methyl-9H-I(2)-carboline, BPBio1_000616, 1-Methyl-9H-beta-carboline #, cid_5281404, KBio1_001649, KBio2_001606, KBio2_004174, KBio2_006742, KBio3_001850, DTXCID40120059, HMS2858P09, HMS3261J12, HMS3267O04, HMS3412K19, HMS3676K19, WLN: T B656 EN HMJ F, ALBB-009251, BCP31368, Tox21_500605, BDBM50013786, HB1665, STK501254, 1-Methyl-9H-Pyrido[3,4-6]indole, 1-Methyl-9H-beta-carboline (Harman), AKOS002664659, CCG-204694, LP00605, SDCCGMLS-0066938.P001, SDCCGSBI-0050587.P003, NCGC00015514-01, NCGC00015514-02, NCGC00015514-03, NCGC00015514-04, NCGC00015514-05, NCGC00015514-06, NCGC00015514-07, NCGC00015514-08, NCGC00015514-09, NCGC00015514-10, NCGC00015514-16, NCGC00025022-01, NCGC00025022-02, NCGC00025022-03, NCGC00025022-04, NCGC00025022-05, NCGC00025022-06, NCGC00261290-01, AC-15673, AS-42735, SMR000538681, CAS-21655-84-5, HY-101392, AB00052849, CS-0021283, EU-0100605, NS00014584, C09209, H 7258, H-1150, SR-01000075915-1, SR-01000075915-7, SR-01000075915-8, BRD-K12630395-001-14-9, BRD-K12630395-003-03-8, Q15411006
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