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  Psychoactive Plant Database - Neuroactive Phytochemical Collection





Worldwide, there are plants known as psychoactive plants that naturally contain psychedelic active components. They have a high concentration of neuroprotective substances that can interact with the nervous system to produce psychedelic effects. Despite these plants' hazardous potential, recreational use of them is on the rise because of their psychoactive properties. Early neuroscience studies relied heavily on psychoactive plants and plant natural products (NPs), and both recreational and hazardous NPs have contributed significantly to the understanding of almost all neurotransmitter systems. Worldwide, there are many plants that contain psychoactive properties, and people have been using them for ages. Psychoactive plant compounds may significantly alter how people perceive the world.

 

Compound Summary

 

PLANT NAME:- Banisteriopsis caapi     PPD ID:- PPD-ID1_10


COMPOUND/COMMON NAME:- harmaline
CAS ID
304-21-2
INCHI KEY
1S/C13H14N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-4,7,15H,5-6H2,1-2H3
MOLECULAR WEIGHT
214.26
MOLECULAR FORMULA
C13H14N2O
MOLECULAR MASS
214.268
BIOLOGICAL SOURCE
Banisteriopsis caapi
DATA SOURCE
Vivek-Ananth, R. P., Mohanraj, K., Sahoo, A. K., & Samal, A. (2023). IMPPAT 2.0: An Enhanced and Expanded Phytochemical Atlas of Indian Medicinal Plants. ACS omega, 8(9), 8827–8845. https://doi.org/10.1021/acsomega.3c00156; Morales-García, J.A., de la Fuente Revenga, M., Alonso-Gil, S. et al. The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro . Sci Rep 7, 5309 (2017). https://doi.org/10.1038/s41598-017-05407-9 ; Santos, B. W. L., Moreira, D. C., Borges, T. K. D. S., & Caldas, E. D. (2022). Components of Banisteriopsis caapi, a Plant Used in the Preparation of the Psychoactive Ayahuasca, Induce Anti-Inflammatory Effects in Microglial Cells. Molecules (Basel, Switzerland), 27(8), 2500. https://doi.org/10.3390/molecules27082500; PUBCHEM
CHEMICAL CLASS OF COMPOUND
Harmala alkaloids
NLRP3 DOCKING SCORE(Kcal/mol)
-4.375
CANONICAL SMILES   COc1ccc2c3c([nH]c2c1)C(C)=NCC3
BIOACTIVITY REPORTED FOR NEURODEGENERATIVE DISEASES   Yes
SYNONYMS
harmaline, 304-21-2, Dihydroharmine, Harmidine, Armalin, 3,4-Dihydroharmine, Harmalol methyl ether, O-Methylharmalol, Harmine, dihydro-, 3H-Pyrido[3,4-b]indole, 4,9-dihydro-7-methoxy-1-methyl-, 7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole, harmalin, NSC 407285, 1-Methyl-7-methoxy-3,4-dihydro-beta-carboline, Dihydro-Harmine, UNII-CN58I4TOET, 3H-Pyrido(3,4-b)indole, 4,9-dihydro-7-methoxy-1-methyl-, CN58I4TOET, 7-Methoxy-1-methyl-4,9-dihydro-3H-beta-carboline, EINECS 206-152-6, 4,9-Dihydro-7-methoxy-1-methyl-3H-pyrido(3,4-b)indole, BRN 0207310, 3, 4-Dihydroharmine, CHEBI:28172, HSDB 7645, 3,4-Dihydro-7-methoxy-1-methyl-9-pyrid(3,4-b)indole, 3,4-Dihydro-7-methoxy-1-methyl-9-pyrido(3,4-b)indole, 4,9-Dihydro-7-methoxy-1-methyl-3H-pyrido[3,4-b]indole, 7-methoxy-1-methyl-3,4-dihydro-2H-pyrido[3,4-b]indole, HARMALINE [MI], HARMALINE [HSDB], MFCD00004955, HARMALINE [MART.], NSC-407285, MLS000028746, CHEMBL340807, DTXSID8041038, 7-methoxy-1-methyl-4,9-dihydro-3H-b-carboline, 1-Methyl-7-methoxy-3,4-dihydro-.beta.-carboline, TNP00101, SMR000058221, 3,4-Dihydro-7-methoxy-1-methyl-b-carboline, HARMALINE (MART.), 3,4-Dihydro-7-methoxy-1-methyl-9-pyrid[3,4-b]indole, 3,4-Dihydro-7-methoxy-1-methyl-9H-pyrid[3,4-b]indole, 7-METHOXY-1-METHYL-4,9-DIHYDRO-3H-PYRIDO(3,4-B)INDOLE, 3,4-Dihydroharmin, SR-01000721899, 3,4-Dihydro-7-methoxy-1-methyl-9H-pyrid(3,4-b)indole, 3,4-b]indole, Spectrum_000301, Opera_ID_665, Prestwick0_000610, Prestwick1_000610, Prestwick2_000610, Prestwick3_000610, Spectrum2_000411, Spectrum3_000720, Spectrum4_000824, Spectrum5_001452, 7-methoxy-1-methyl-3,4-dihydrobeta-carboline, 1-Methyl-7-methoxy-3,4-dihydro- beta-carboline, Oprea1_112644, BSPBio_000520, BSPBio_002539, KBioGR_001367, KBioSS_000781, MLS001148231, BIDD:ER0444, DivK1c_000950, SCHEMBL199260, SPECTRUM1500864, SPBio_000362, SPBio_002739, BPBio1_000572, MEGxp0_001874, SCHEMBL3862598, DTXCID6021038, ACon1_000019, CHEBI:95328, GTPL13140, HMS502P12, KBio1_000950, KBio2_000781, KBio2_003349, KBio2_005917, KBio3_001759, NINDS_000950, HMS1921K22, HMS2233L23, HMS3371G17, HMS3885P22, BDBM50029799, CCG-38677, NSC407285, NSC789037, s4776, STL570451, AKOS015904564, AKOS026750619, DB13875, KS-5325, NSC-789037, SDCCGMLS-0066716.P001, IDI1_000950, NCGC00017221-01, NCGC00017221-02, NCGC00017221-03, NCGC00017221-04, NCGC00017221-05, NCGC00017221-06, NCGC00017221-07, NCGC00017221-10, NCGC00094867-01, NCGC00094867-02, NCGC00094867-03, NCGC00094867-04, NCGC00094867-05, NCGC00094867-06, AC-34436, LS-14204, PD056221, WLN: T B656 DM HM CHJ F1 KO1, DB-047778, HY-107828, CS-0030704, H1237, NS00017928, 3,4-Dihydro-7-methoxy-1-methyl-beta-carboline, C06536, H-1100, H-1102, 1-Methyl-7-methoxy-3, 4-dihydro-beta-carboline, 1-Methyl-7-methoxy-3,4-dihydro-beta -carboline, 1-Methyl-7-methoxy-3, 4-dihydro-beta -carboline, 3H-Pyrido[3, 4,9-dihydro-7-methoxy-1-methyl-, 7-Methoxy-1-methyl-4,9-dihydro-3H-?-carboline, 7-Methoxy-1-methyl-4,9-dihydro-3H-I2-carboline, Q135270, 7-Methoxy-1-methyl-2,9-dihydro-1H-beta-carboline, 7-methoxy-1-methyl-3,4-dihydro-2h-beta-carboline, A1-00783, SR-01000721899-4, SR-01000721899-5, 7-Methoxy-1-methyl-4,9-dihydro-3H-beta-carboline #, BRD-K91317041-001-03-8, BRD-K91317041-310-03-3, 3,4-Dihydro-7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
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